KEGG ORTHOLOGY: K19743

ORTHOLOGY: K19743

Entry

K19743 KO

Name

lhpI

Definition

1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]

Pathway

ko00310

Lysine degradation

ko00330

Arginine and proline metabolism

ko00960

Tropane, piperidine and pyridine alkaloid biosynthesis

ko01100

Metabolic pathways

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K19743  lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
   00330 Arginine and proline metabolism
    K19743  lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
  09110 Biosynthesis of other secondary metabolites
   00960 Tropane, piperidine and pyridine alkaloid biosynthesis
    K19743  lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.1  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
     K19743  lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

Other DBs

RN:	R01246 R01249 R02201 R02203

COG:

COG2423

GO:

0050241

Genes

BGJ:	AWC36_18660

LBQ:	CKQ53_13775

SOD:

Sant_2254

PAZO:

AYR47_02320

PCH:	EY04_18125

PSES:

PSIL:

SPIU:

SROS:

PSE:

AMAH:

RSC:	RCFBP_10114

RSL:	RPSI07_0093

RSN:	RSPO_c00089

RSM:	CMR15_10116

RSE:

F504_3400

RSY:	RSUY_01390(rapL_1)

RPI:

Rpic_3546

RPF:	Rpic12D_3222

RPJ:	N234_20505

RMN:	TK49_02570

RIN:	ACS15_3655

RPU:	CDC45_17140

CNC:	CNE_1c36230

CUH:	BJN34_19590

CTI:	RALTA_A3129

CBW:	RR42_m4138

CGD:

CR3_2832

CCUP:

BKK81_01450

CUP:	BKK80_00785

CUU:	BKK79_11375

CPAU:

EHF44_05820

COX:	E0W60_27530

BMA:

BMAA1290

BMV:	BMASAVP1_0266

BML:	BMA10229_0536

BMN:	BMA10247_A1031

BMAL:

BMAE:

BMAQ:

BMAI:

BMAF:

BMAZ:

BMAB:

BPS:

BPM:	BURPS1710b_A2543

BPL:	BURPS1106A_A1291

BPD:	BURPS668_A1371

BPSE:

BPSM:

BPSU:

BPSD:

BPZ:	BP1026B_II1030

BPQ:	BPC006_II1306

BPK:

BPSH:

BPSA:

BPSO:

BUT:

BTE:	BTH_II1457

BTQ:

BTJ:

BTZ:

BTD:

BTV:

BTHE:

BTHM:

BTHA:

BTHL:

BOK:

BOC:

BUU:	WS70_22180

BVI:	Bcep1808_4889 Bcep1808_6676

BVE:

AK36_4029

BUR:	Bcep18194_B1663

BCN:

Bcen_4010

BCH:	Bcen2424_4357

BCM:	Bcenmc03_5997

BCJ:

BCEN:

BCEW:

BCEO:

BAM:

BAC:	BamMC406_4240

BMU:

BMK:

BMUL:

BCT:

BCED:

BCEP:

BDL:

BPYR:

BCON:

BUB:

BDF:	WI26_20365

BLAT:

BTEI:

BSEM:

BPSL:

BMEC:

BSTG:

BSTL:

BGL:	bglu_2g07030

BGU:

KS03_5219

BUG:	BC1001_5631

BGF:	BC1003_5729

BGD:	bgla_2g12060

BGO:

BM43_4860

BYI:	BYI23_B003960 BYI23_C005280

BUK:

MYA_4327

BUE:	BRPE67_BCDS06550 BRPE67_CCDS06230

BUL:

BW21_5442

BUQ:	AC233_30570

BGP:	BGL_2c21310

BPLA:

bpln_2g21410

BUD:	AQ610_25980

BUM:	AXG89_39245

BUI:	AX768_21115

BXE:

Bxe_B1765

BXB:

DR64_7069

BPH:

Bphy_3343

BGE:	BC1002_3728

BPX:	BUPH_06129

BPY:	Bphyt_4907

BUZ:	AYM40_24630

BFN:

OI25_4196

BCAI:

K788_0008493

PSPW:

BJG93_16945 BJG93_30575

PARA:

BTO02_28190

PARB:

CJU94_20935

PHS:	C2L64_27315

PTER:

C2L65_21185

PGP:	CUJ91_25630 CUJ91_31175

PCJ:	CUJ87_19665

PTS:	CUJ90_18630

PCAF:

DSC91_001681

PMEG:

FNZ07_10020

PPK:	U875_23685

PPNO:

DA70_16420

PPNM:

LV28_14325

PRB:	X636_10455

PPUL:

RO07_08380

PSPU:

NA29_04175

PAPI:

SG18_08825

PVE:	UC34_24400

POX:	MB84_04495

PTX:	ABW99_16995

PFG:	AB870_11355

PNR:	AT302_07940

PAND:

DRB87_22880

PFIB:

PI93_024530

CABA:

SBC2_64960(ocd_1)

BUO:	BRPE64_BCDS09290

AKA:	TKWG_24615

AMIM:

MIM_c39830

CDN:	BN940_16136

BPSI:

IX83_00760

AFA:	UZ73_14790

AFQ:

AFA_14940

AAQU:

D3M96_15870

PHN:	PAEH1_12825

ODI:

ODI_R1977

RHF:	EUB48_17055

POS:	DT070_01085

POO:	F7R28_08365

AAV:

Aave_3400

AAA:

Acav_1835

ACK:	C380_05510

ACRA:

ACID:

ACIP:

ACIN:

ACIS:

AMON:

VEI:

DAC:

DEL:	DelCs14_4535

DTS:	BI380_13765

DHK:	BO996_10010

DLA:	I6G47_13785

CTT:	CtCNB1_3667

CTES:

O987_21445

CKE:	B5M06_09815

COF:	FOZ74_12640

RTA:

Rta_32100

OTK:	C6570_17210

HYR:

HYB:

MPT:

METP:

HSE:	Hsero_0176

HSZ:	ACP92_00875

HHT:	F506_21360

HRB:	Hrubri_0191

HEE:	hmeg3_22520

HHF:	E2K99_01140

HFR:	G5S34_00880

CFU:

CARE:

CPRA:

MPLI:

NOK:	FAY22_03770

RDP:	RD2015_1338

PKT:	AT984_14370

MIU:	ABE85_00125

NET:	Neut_2183 Neut_2213

DMA:	DMR_28030(ocd)

DGG:

DGI_1547

DFL:

DFE_1833

DCB:	C3Y92_12855

DSD:	GD606_02995

DAF:	Desaf_2510

DSX:	GD604_10005

ZMO:

ZMN:

ZMB:

ZMI:

ZMC:	A265_01223

ZMR:	A254_01222

GOH:

B932_1581

GAL:	A0U94_09505

GTI:	FXF46_03430

GXL:

H845_2323

KNA:	B0W47_06280

KEU:	S101446_01615

KSC:	CD178_02861

KHA:	IFJ82_02935

APT:	APA01_08140

APW:	APA42C_08140

APF:	APA03_08140

APU:	APA07_08140

APG:	APA12_08140

APQ:	APA22_08140

APX:	APA26_08140

APZ:	APA32_08140

APK:	APA386B_2319

ASZ:	ASN_1466(ocd)

ASV:	WG31_04555

APOM:

CPF11_03415

ATO:	CIW82_00155 CIW82_04965

AASC:

A4S02_02110

ACET:

DS739_04260

AOY:	EOV40_003815

NCH:	A0U93_11420

AZL:	AZL_d02350(ocd)

ALI:	AZOLI_p40331

ATI:	AL072_25090

AZM:	DM194_22605

AOZ:	HUE56_04635

MABB:

MASS_0271

MFOL:

DXT68_01230

LEB:	G7066_05135

ARM:

ART_2600

ARE:	AL755_00500

AAQ:	AOC05_16100

RXY:

Rxyl_2927

RUB:	GBA63_16515

DDR:	Deide_3p02181

TRA:

Trad_0061

TTL:	TtJL18_1410

TSC:	TSC_c14850

THC:	TCCBUS3UF1_9890

TOS:	Theos_1094

TAQ:

TO73_1277

TPAR:

AV541_07340

TBC:	A0O31_02061(ocd)

MRB:

Mrub_0429

MRE:	K649_01770

MSV:	Mesil_1519

MTAI:

Mtai_v1c03530

OPR:	Ocepr_1284

MHD:	Marky_1461

» show all

Reference

PMID:24649405

Authors

Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y

Title

Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.

Journal

FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010

Sequence

[bur:Bcep18194_B1663]

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (1)   
   COG (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
   KEGG RCLASS (1)   
Gene (329)   
   KEGG GENES (279)   
   KEGG MGENES (45)   
   RefGene (3)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (348)   

Download RDF

ENZYME: 1.5.1.1

Entry

EC 1.5.1.1 Enzyme

Name

1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H];
Delta1-pyrroline-2-carboxylate reductase;
DELTA1-pyrroline-2-carboxylate reductase;
DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous);
AbLhpI;
pyrroline-2-carboxylate reductase;
L-proline:NAD(P)+ 2-oxidoreductase

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-pipecolate/L-proline:NAD(P)+ 2-oxidoreductase

Reaction(IUBMB)

(1) L-pipecolate + NAD(P)+ = 1-piperideine-2-carboxylate + NAD(P)H + H+ [RN:R02201 R02203];
(2) L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]

Reaction(KEGG)

R01246 R01249 R02201 R02203

Substrate

L-pipecolate [CPD:C00408];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
L-proline [CPD:C00148]

Product

1-piperideine-2-carboxylate [CPD:C04092];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
1-pyrroline-2-carboxylate [CPD:C03564]

Comment

The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.

History

EC 1.5.1.1 created 1961, modified 2015

Pathway

ec00310

Lysine degradation

ec00330

Arginine and proline metabolism

ec00960

Tropane, piperidine and pyridine alkaloid biosynthesis

ec01100

Metabolic pathways

Orthology

K19743

1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

Genes

BGJ:	AWC36_18660

LBQ:	CKQ53_13775

SOD:

Sant_2254

PAZO:

AYR47_02320

PCH:	EY04_18125

PSES:

PSIL:

SPIU:

SROS:

PSE:

AMAH:

RSC:	RCFBP_10114

RSL:	RPSI07_0093

RSN:	RSPO_c00089

RSM:	CMR15_10116

RSE:

F504_3400

RSY:	RSUY_01390(rapL_1)

RPI:

Rpic_3546

RPF:	Rpic12D_3222

RPJ:	N234_20505

RMN:	TK49_02570

RIN:	ACS15_3655

RPU:	CDC45_17140

CNC:	CNE_1c36230

CUH:	BJN34_19590

CTI:	RALTA_A3129

CBW:	RR42_m4138

CGD:

CR3_2832

CCUP:

BKK81_01450

CUP:	BKK80_00785

CUU:	BKK79_11375

CPAU:

EHF44_05820

COX:	E0W60_27530

BMA:

BMAA1290

BMV:	BMASAVP1_0266

BML:	BMA10229_0536

BMN:	BMA10247_A1031

BMAL:

BMAE:

BMAQ:

BMAI:

BMAF:

BMAZ:

BMAB:

BPS:

BPM:	BURPS1710b_A2543

BPL:	BURPS1106A_A1291

BPD:	BURPS668_A1371

BPSE:

BPSM:

BPSU:

BPSD:

BPZ:	BP1026B_II1030

BPQ:	BPC006_II1306

BPK:

BPSH:

BPSA:

BPSO:

BUT:

BTE:	BTH_II1457

BTQ:

BTJ:

BTZ:

BTD:

BTV:

BTHE:

BTHM:

BTHA:

BTHL:

BOK:

BOC:

BUU:	WS70_22180

BVI:	Bcep1808_4889 Bcep1808_6676

BVE:

AK36_4029

BUR:	Bcep18194_B1663

BCN:

Bcen_4010

BCH:	Bcen2424_4357

BCM:	Bcenmc03_5997

BCJ:

BCEN:

BCEW:

BCEO:

BAM:

BAC:	BamMC406_4240

BMU:

BMK:

BMUL:

BCT:

BCED:

BCEP:

BDL:

BPYR:

BCON:

BUB:

BDF:	WI26_20365

BLAT:

BTEI:

BSEM:

BPSL:

BMEC:

BSTG:

BSTL:

BGL:	bglu_2g07030

BGU:

KS03_5219

BUG:	BC1001_5631

BGF:	BC1003_5729

BGD:	bgla_2g12060

BGO:

BM43_4860

BYI:	BYI23_B003960 BYI23_C005280

BUK:

MYA_4327

BUE:	BRPE67_BCDS06550 BRPE67_CCDS06230

BUL:

BW21_5442

BUQ:	AC233_30570

BGP:	BGL_2c21310

BPLA:

bpln_2g21410

BUD:	AQ610_25980

BUM:	AXG89_39245

BUI:	AX768_21115

BXE:

Bxe_B1765

BXB:

DR64_7069

BPH:

Bphy_3343

BGE:	BC1002_3728

BPX:	BUPH_06129

BPY:	Bphyt_4907

BUZ:	AYM40_24630

BFN:

OI25_4196

BCAI:

K788_0008493

PSPW:

BJG93_16945 BJG93_30575

PARA:

BTO02_28190

PARB:

CJU94_20935

PHS:	C2L64_27315

PTER:

C2L65_21185

PGP:	CUJ91_25630 CUJ91_31175

PCJ:	CUJ87_19665

PTS:	CUJ90_18630

PCAF:

DSC91_001681

PMEG:

FNZ07_10020

PPK:	U875_23685

PPNO:

DA70_16420

PPNM:

LV28_14325

PRB:	X636_10455

PPUL:

RO07_08380

PSPU:

NA29_04175

PAPI:

SG18_08825

PVE:	UC34_24400

POX:	MB84_04495

PTX:	ABW99_16995

PFG:	AB870_11355

PNR:	AT302_07940

PAND:

DRB87_22880

PFIB:

PI93_024530

CABA:

SBC2_64960(ocd_1)

BUO:	BRPE64_BCDS09290

AKA:	TKWG_24615

AMIM:

MIM_c39830

CDN:	BN940_16136

BPSI:

IX83_00760

AFA:	UZ73_14790

AFQ:

AFA_14940

AAQU:

D3M96_15870

PHN:	PAEH1_12825

ODI:

ODI_R1977

RHF:	EUB48_17055

POS:	DT070_01085

POO:	F7R28_08365

AAV:

Aave_3400

AAA:

Acav_1835

ACK:	C380_05510

ACRA:

ACID:

ACIP:

ACIN:

ACIS:

AMON:

VEI:

DAC:

DEL:	DelCs14_4535

DTS:	BI380_13765

DHK:	BO996_10010

DLA:	I6G47_13785

CTT:	CtCNB1_3667

CTES:

O987_21445

CKE:	B5M06_09815

COF:	FOZ74_12640

RTA:

Rta_32100

OTK:	C6570_17210

HYR:

HYB:

MPT:

METP:

HSE:	Hsero_0176

HSZ:	ACP92_00875

HHT:	F506_21360

HRB:	Hrubri_0191

HEE:	hmeg3_22520

HHF:	E2K99_01140

HFR:	G5S34_00880

CFU:

CARE:

CPRA:

MPLI:

NOK:	FAY22_03770

RDP:	RD2015_1338

PKT:	AT984_14370

MIU:	ABE85_00125

NET:	Neut_2183 Neut_2213

DMA:	DMR_28030(ocd)

DGG:

DGI_1547

DFL:

DFE_1833

DCB:	C3Y92_12855

DSD:	GD606_02995

DAF:	Desaf_2510

DSX:	GD604_10005

ZMO:

ZMN:

ZMB:

ZMI:

ZMC:	A265_01223

ZMR:	A254_01222

GOH:

B932_1581

GAL:	A0U94_09505

GTI:	FXF46_03430

GXL:

H845_2323

KNA:	B0W47_06280

KEU:	S101446_01615

KSC:	CD178_02861

KHA:	IFJ82_02935

APT:	APA01_08140

APW:	APA42C_08140

APF:	APA03_08140

APU:	APA07_08140

APG:	APA12_08140

APQ:	APA22_08140

APX:	APA26_08140

APZ:	APA32_08140

APK:	APA386B_2319

ASZ:	ASN_1466(ocd)

ASV:	WG31_04555

APOM:

CPF11_03415

ATO:	CIW82_00155 CIW82_04965

AASC:

A4S02_02110

ACET:

DS739_04260

AOY:	EOV40_003815

NCH:	A0U93_11420

AZL:	AZL_d02350(ocd)

ALI:	AZOLI_p40331

ATI:	AL072_25090

AZM:	DM194_22605

AOZ:	HUE56_04635

MABB:

MASS_0271

MFOL:

DXT68_01230

LEB:	G7066_05135

ARM:

ART_2600

ARE:	AL755_00500

AAQ:	AOC05_16100

RXY:

Rxyl_2927

RUB:	GBA63_16515

DDR:	Deide_3p02181

TRA:

Trad_0061

TTL:	TtJL18_1410

TSC:	TSC_c14850

THC:	TCCBUS3UF1_9890

TOS:	Theos_1094

TAQ:

TO73_1277

TPAR:

AV541_07340

TBC:	A0O31_02061(ocd)

MRB:

Mrub_0429

MRE:	K649_01770

MSV:	Mesil_1519

MTAI:

Mtai_v1c03530

OPR:	Ocepr_1284

MHD:	Marky_1461

» show all

Reference

1 [PMID:13502341]

Authors

MEISTER A, RADHAKRISHNAN AN, BUCKLEY SD.

Title

Enzymatic synthesis of L-pipecolic acid and L-proline.

Journal

J Biol Chem 229:789-800 (1957)

Reference

2 [PMID:24649405]

Authors

Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y

Title

Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.

Journal

FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010

Sequence

[bur:Bcep18194_B1663]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.1

IUBMB Enzyme Nomenclature:

1.5.1.1

ExPASy - ENZYME nomenclature database:

1.5.1.1

BRENDA, the Enzyme Database:

1.5.1.1

CAS:

9029-16-7

REACTION: R01246

Entry

R01246 Reaction

Name

L-proline:NAD+ 2-oxidoreductase

Definition

L-Proline + NAD+ <=> 1-Pyrroline-2-carboxylate + NADH + H+

Equation

C00148 + C00003 <=> C03564 + C00004 + C00080

Comment

NADP+ (see R01249)

Reaction class

RC00001

C00003_C00004

RC00135

C00148_C03564

Enzyme

1.5.1.1 1.5.1.49

Pathway

rn00330

Arginine and proline metabolism

Orthology

K19742

1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]

K19743

1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]

Other DBs

RHEA:

20324

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG RCLASS (2)   
Gene (333)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (331)   
All databases (345)   

Download RDF

REACTION: R01249

Entry

R01249 Reaction

Name

L-proline:NADP+ 2-oxidoreductase

Definition

L-Proline + NADP+ <=> 1-Pyrroline-2-carboxylate + NADPH + H+

Equation

C00148 + C00006 <=> C03564 + C00005 + C00080

Comment

NAD+ (see R01246)

Reaction class

RC00001

C00005_C00006

RC00135

C00148_C03564

Enzyme

1.5.1.1 1.5.1.21 1.5.1.49

Pathway

rn00330

Arginine and proline metabolism

Orthology

K19742

1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]

K19743

1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]

Other DBs

RHEA:

20320

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (5)   
   KEGG ENZYME (3)   
   KEGG RCLASS (2)   
Gene (333)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (331)   
All databases (346)   

Download RDF

DBGET integrated database retrieval system