KEGG   ORTHOLOGY: K19793
Entry
K19793                      KO                                     

Name
mfnC
Definition
(5-formylfuran-3-yl)methyl phosphate transaminase [EC:2.6.1.108]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01240  Biosynthesis of cofactors
Module
M00935  Methanofuran biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K19793  mfnC; (5-formylfuran-3-yl)methyl phosphate transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.108  (5-formylfuran-3-yl)methyl phosphate transaminase
     K19793  mfnC; (5-formylfuran-3-yl)methyl phosphate transaminase
Other DBs
RN: R11038
COG: COG0436
Genes
PACE: A6070_12195
PEF: A7E78_07625
DMA: DMR_45090
DGG: DGI_1983
DPG: DESPIGER_0708
DFL: DFE_0184
DCB: C3Y92_19395
DMS: E8L03_06035
DSD: GD606_15175
DEJ: AWY79_08275
PPRF: DPRO_2977(mfnC)
DML: Dmul_38010(aspC3)
DAT: HRM2_10800(aspC2)
DALK: DSCA_41500
DBR: Deba_0092
LPIL: LIP_0260
BTHO: Btheta7330_04576(patA_2)
BXY: BXY_47810
BOA: Bovatus_03826(patA_3)
MJA: MJ_0684
MBAR: MSBR2_2861
MBAK: MSBR3_1827
MAC: MA_0636(aspC)
MMA: MM_1802
MMAC: MSMAC_1551
METM: MSMTP_2810
MTHR: MSTHT_2208
MTHE: MSTHC_1072
MHOR: MSHOH_3582
MMET: MCMEM_1376
MMH: Mmah_1336
MPY: Mpsy_0899
MCJ: MCON_2279(aspC)
MHI: Mhar_2101
MPD: MCP_1841
HSL: OE_2619F(aspC3)
HALH: HTSR_0784(aspC2)
HHSR: HSR6_0811(aspC2)
HSU: HLASF_1472(aspC5)
HSF: HLASA_1459(aspC5)
 » show all
Reference
  Authors
Miller D, Wang Y, Xu H, Harich K, White RH
  Title
Biosynthesis of the 5-(Aminomethyl)-3-furanmethanol moiety of methanofuran.
  Journal
Biochemistry 53:4635-47 (2014)
DOI:10.1021/bi500615p
  Sequence
[mja:MJ_0684]

KEGG   ENZYME: 2.6.1.108
Entry
EC 2.6.1.108                Enzyme                                 

Name
(5-formylfuran-3-yl)methyl phosphate transaminase;
mfnC (gene name);
[5-(hydroxymethyl)furan-3-yl]methyl phosphate transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-alanine:(5-formylfuran-3-yl)methyl phosphate aminotransferase
Reaction(IUBMB)
L-alanine + (5-formylfuran-3-yl)methyl phosphate = pyruvate + [5-(aminomethyl)furan-3-yl]methyl phosphate [RN:R11038]
Reaction(KEGG)
R11038
Substrate
L-alanine [CPD:C00041];
(5-formylfuran-3-yl)methyl phosphate [CPD:C20954]
Product
pyruvate [CPD:C00022];
[5-(aminomethyl)furan-3-yl]methyl phosphate [CPD:C21068]
Comment
A pyridoxal 5'-phosphate protein. The enzyme, characterized from the archaebacterium Methanocaldococcus jannaschii, participates in the biosynthesis of the cofactor methanofuran. Requires pyridoxal 5'-phosphate.
History
EC 2.6.1.108 created 2015
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
Orthology
K19793  (5-formylfuran-3-yl)methyl phosphate transaminase
Genes
PACE: A6070_12195
PEF: A7E78_07625
DMA: DMR_45090
DGG: DGI_1983
DPG: DESPIGER_0708
DFL: DFE_0184
DCB: C3Y92_19395
DMS: E8L03_06035
DSD: GD606_15175
DEJ: AWY79_08275
PPRF: DPRO_2977(mfnC)
DML: Dmul_38010(aspC3)
DAT: HRM2_10800(aspC2)
DALK: DSCA_41500
DBR: Deba_0092
LPIL: LIP_0260
BTHO: Btheta7330_04576(patA_2)
BXY: BXY_47810
BOA: Bovatus_03826(patA_3)
MJA: MJ_0684
MBAR: MSBR2_2861
MBAK: MSBR3_1827
MAC: MA_0636(aspC)
MMA: MM_1802
MMAC: MSMAC_1551
METM: MSMTP_2810
MTHR: MSTHT_2208
MTHE: MSTHC_1072
MHOR: MSHOH_3582
MMET: MCMEM_1376
MMH: Mmah_1336
MPY: Mpsy_0899
MCJ: MCON_2279(aspC)
MHI: Mhar_2101
MPD: MCP_1841
HSL: OE_2619F(aspC3)
HALH: HTSR_0784(aspC2)
HHSR: HSR6_0811(aspC2)
HSU: HLASF_1472(aspC5)
HSF: HLASA_1459(aspC5)
 » show all
Reference
1  [PMID:24977328]
  Authors
Miller D, Wang Y, Xu H, Harich K, White RH
  Title
Biosynthesis of the 5-(Aminomethyl)-3-furanmethanol moiety of methanofuran.
  Journal
Biochemistry 53:4635-47 (2014)
DOI:10.1021/bi500615p
  Sequence
[mja:MJ_0684]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.108
IUBMB Enzyme Nomenclature: 2.6.1.108
ExPASy - ENZYME nomenclature database: 2.6.1.108
BRENDA, the Enzyme Database: 2.6.1.108

KEGG   REACTION: R11038
Entry
R11038                      Reaction                               

Name
L-alanine:(5-formylfuran-3-yl)methyl-phosphate aminotransferase
Definition
(5-Formylfuran-3-yl)methyl phosphate + L-Alanine <=> [5-(Aminomethyl)furan-3-yl]methyl phosphate + Pyruvate
Equation
Comment
(5-formylfuran-3-yl)methyl phosphate transaminase
Reaction class
RC00008  C00022_C00041
RC00048  C20954_C21068
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00935  Methanofuran biosynthesis
Orthology
K19793  (5-formylfuran-3-yl)methyl phosphate transaminase [EC:2.6.1.108]
Other DBs
RHEA: 43567

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