KEGG   ORTHOLOGY: K19795
Entry
K19795                      KO                                     

Name
E3.5.1.95
Definition
ureidomalonase [EC:3.5.1.95]
Pathway
ko00240  Pyrimidine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    K19795  E3.5.1.95; ureidomalonase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.95  N-malonylurea hydrolase
     K19795  E3.5.1.95; ureidomalonase
Other DBs
RN: R07629 R10778
GO: 0033970
Genes
RHA: RHA1_ro05297
RER: RER_58810
REY: O5Y_28305
REB: XU06_28635
ROP: ROP_27980
ROA: Pd630_LPD01827
RFA: A3L23_03490(aam_3)
RHS: A3Q41_04765(aam_3)
RQI: C1M55_30120
RHOD: AOT96_09770
SEN: SACE_1914
AMYY: YIM_43870(aam4)
 » show all
Reference
  Authors
Horinouchi N, Soon CL, Shimizu S, Ogawa J.
  Title
Oxidative pyrimidine metabolism in Rhodococcus erythropolis useful for valuable nucleoside synthesis: Discovery of a novel amidohydorolase, ureidomalonase.
  Journal
Biocatal Agricult Biotechnol 1:264-266 (2012)
DOI:10.1016/j.bcab.2012.03.011
  Sequence
[rey:O5Y_28305]

KEGG   ENZYME: 3.5.1.95
Entry
EC 3.5.1.95                 Enzyme                                 

Name
N-malonylurea hydrolase;
ureidomalonase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming)
Reaction(IUBMB)
3-oxo-3-ureidopropanoate + H2O = malonate + urea [RN:R07629]
Reaction(KEGG)
R07629;
(other) R10778
Substrate
3-oxo-3-ureidopropanoate [CPD:C15607];
H2O [CPD:C00001]
Product
malonate [CPD:C00383];
urea [CPD:C00086]
Comment
Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.2.1 (barbiturase).
History
EC 3.5.1.95 created 2006
Pathway
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K19795  ureidomalonase
Genes
RHA: RHA1_ro05297
RER: RER_58810
REY: O5Y_28305
REB: XU06_28635
ROP: ROP_27980
ROA: Pd630_LPD01827
RFA: A3L23_03490(aam_3)
RHS: A3Q41_04765(aam_3)
RQI: C1M55_30120
RHOD: AOT96_09770
SEN: SACE_1914
AMYY: YIM_43870(aam4)
 » show all
Reference
1  [PMID:11485332]
  Authors
Soong CL, Ogawa J, Shimizu S.
  Title
Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase.
  Journal
Biochem Biophys Res Commun 286:222-6 (2001)
DOI:10.1006/bbrc.2001.5356
Reference
2  [PMID:11748240]
  Authors
Soong CL, Ogawa J, Sakuradani E, Shimizu S.
  Title
Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism.
  Journal
J Biol Chem 277:7051-8 (2002)
DOI:10.1074/jbc.M110784200
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.95
IUBMB Enzyme Nomenclature: 3.5.1.95
ExPASy - ENZYME nomenclature database: 3.5.1.95
BRENDA, the Enzyme Database: 3.5.1.95
CAS: 368888-22-6

KEGG   REACTION: R07629
Entry
R07629                      Reaction                               

Name
3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming)
Definition
3-Oxo-3-ureidopropanoate + H2O <=> Malonate + Urea
Equation
Reaction class
RC00090  C00383_C15607
RC00811  C00086_C15607
Enzyme
Pathway
rn00240  Pyrimidine metabolism
rn01100  Metabolic pathways
Orthology
K19795  ureidomalonase [EC:3.5.1.95]
Other DBs
RHEA: 17364

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