KEGG   ORTHOLOGY: K19857
Entry
K19857            Tight     KO                                     

Name
aveBIV, avrE
Definition
dTDP-4-keto-6-deoxy-L-hexose 4-reductase
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00799  dTDP-L-oleandrose biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K19857  aveBIV, avrE; dTDP-4-keto-6-deoxy-L-hexose 4-reductase
Other DBs
RN: R11042
Genes
SMA: SAVERM_948(aveBIV)
Reference
  Authors
Wohlert S, Lomovskaya N, Kulowski K, Fonstein L, Occi JL, Gewain KM, MacNeil DJ, Hutchinson CR
  Title
Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans.
  Journal
Chem Biol 8:681-700 (2001)
DOI:10.1016/S1074-5521(01)00043-6
Reference
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence

KEGG   REACTION: R11042
Entry
R11042                      Reaction                               

Definition
dTDP-3-O-methyl-4-oxo-2,6-dideoxy-L-mannose <=> dTDP-L-oleandrose
Equation
Comment
4-ketoreductase, aveBIV, avrE
Reaction class
RC00182  C11921_C21071
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00799  dTDP-L-oleandrose biosynthesis
Orthology
K19857  dTDP-4-keto-6-deoxy-L-hexose 4-reductase

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