KEGG   ORTHOLOGY: K19969
Entry
K19969                      KO                                     

Name
acbC, salQ, valA, cetA
Definition
2-epi-5-epi-valiolone synthase [EC:4.2.3.152]
Pathway
ko00525  Acarbose and validamycin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00814  Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K19969  acbC, salQ, valA, cetA; 2-epi-5-epi-valiolone synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.152  2-epi-5-epi-valiolone synthase
     K19969  acbC, salQ, valA, cetA; 2-epi-5-epi-valiolone synthase
Other DBs
RN: R10937
Genes
SERA: Ser39006_003950
SERQ: CWC46_03950
RHD: R2APBS1_3641
PFC: PflA506_4591
CJA: CJA_3250
GPB: HDN1F_13870(acbC)
CVC: BKX93_19945
BTZ: BTL_4163
BOK: DM82_5622
COF: FOZ74_00740
SUR: STAUR_1386(gacC)
CFUS: CYFUS_007478
MEE: DA075_19375
BBY: CY96_27945
CBB: CLD_3207
MMI: MMAR_0578(aroB_1)
MMAE: MMARE11_05350(aroB_1)
MHAD: B586_06435
NSR: NS506_05945
NAH: F5544_18765
NAD: NCTC11293_02222(aroB_1)
RER: RER_54360
REY: O5Y_25890
REB: XU06_26170
RHB: NY08_95
RHS: A3Q41_04747(aroB_3)
RTM: G4H71_11885
TSM: ASU32_10315
SRT: Srot_2448
SHY: SHJG_0276
SHO: SHJGH_0110
SALS: SLNWT_0595
SGU: SGLAU_01035(gacC)
STRM: M444_32560
SCZ: ABE83_10155
SRW: TUE45_05037(aroB_3)
SLE: sle_45870(sle_45870)
SCLF: BB341_29000
SLS: SLINC_5104
SSIA: A7J05_03495
SFK: KY5_0702
SRJ: SRO_6646
SCYA: EJ357_02100 EJ357_14575
SAST: CD934_05045
SNQ: CP978_00070
SKA: CP970_39485
SGZ: C0216_19350
SRK: FGW37_17500
SFIC: EIZ62_30660
SSPO: DDQ41_30765
SGF: HEP81_06989(gacC)
KIT: CFP65_6096
XYA: ET471_00715
AER: AERYTH_07130
NGV: CDO52_07210
FAL: FRAAL4639
AOI: AORI_5447(aroB)
AJA: AJAP_35530
AMYC: CU254_12845
AORI: SD37_10235
SESP: BN6_52640
ACTI: UA75_21530
ACAD: UA74_21050
STP: Strop_2345
SAQ: Sare_2489
MCAB: HXZ27_14335
ASE: ACPL_3680(acbC) ACPL_6250
ACTS: ACWT_3552 ACWT_6118
PLK: CIK06_12685
PLAB: C6361_27335
PLAT: C6W10_29735
CWO: Cwoe_1465
GLP: Glo7428_0525
TSA: AciPR4_1231
AG: ABL74381(cetA)
 » show all
Reference
  Authors
Stratmann A, Mahmud T, Lee S, Distler J, Floss HG, Piepersberg W
  Title
The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.
  Journal
J Biol Chem 274:10889-96 (1999)
DOI:10.1074/jbc.274.16.10889
  Sequence
[ase:ACPL_3680]
Reference
  Authors
Choi WS, Wu X, Choeng YH, Mahmud T, Jeong BC, Lee SH, Chang YK, Kim CJ, Hong SK
  Title
Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.
  Journal
Appl Microbiol Biotechnol 80:637-45 (2008)
DOI:10.1007/s00253-008-1591-2
  Sequence
[sals:SLNWT_0595]
Reference
  Authors
Kean KM, Codding SJ, Asamizu S, Mahmud T, Karplus PA
  Title
Structure of a sedoheptulose 7-phosphate cyclase: ValA from Streptomyces hygroscopicus.
  Journal
Biochemistry 53:4250-60 (2014)
DOI:10.1021/bi5003508
  Sequence
[shy:SHJG_0276]
Reference
  Authors
Wu X, Flatt PM, Xu H, Mahmud T
  Title
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.
  Journal
Chembiochem 10:304-14 (2009)
DOI:10.1002/cbic.200800527
  Sequence

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (8)   
   KEGG PATHWAY (6)   
   KEGG MODULE (2)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (423)   
   KEGG GENES (78)   
   KEGG MGENES (143)   
   RefGene (195)   
   OC (7)   
Literature (4)   
   PubMed (4)   
All databases (440)   

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