KEGG ORTHOLOGY: K19969

ORTHOLOGY: K19969

Entry

K19969                      KO

Symbol

acbC, salQ, valA, cetA

Name

2-epi-5-epi-valiolone synthase [EC:4.2.3.152]

Pathway

map00525

Acarbose and validamycin biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00814

Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose

M00815

Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A

Reaction

R10937

alpha-D-sedoheptulopyranose-7-phosphate phosphate-lyase (cyclizing, 2-epi-5-epi-valiolone-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K19969  acbC, salQ, valA, cetA; 2-epi-5-epi-valiolone synthase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.152  2-epi-5-epi-valiolone synthase
     K19969  acbC, salQ, valA, cetA; 2-epi-5-epi-valiolone synthase

Genes

GGA:

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

CCIC:

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

GSTE:

CBOY:

CLV:

CNIC:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

AROW:

NPD:

TGT:

DNE:

SCAM:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

XLA:	108714718 108715916

XTR:

NPR:

RTEM:

ACAT:

BBUF:

BGAR:

DTC:

DRE:	100003999(eevs)

SRX:	107713488 107750277

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122347017(eevs)

LROH:

127167200(eevs)

GRF:	141347715(eevs)

OMC:	131542646(eevs)

PPRM:

120491286(eevs)

RKG:	130087421(eevs)

MAMB:

125273457(eevs)

CIDE:

127514836

CERY:

137010746(eevs)

MASI:

127445879 127449114

TROS:

130557037(eevs)

TDW:	130425143(eevs)

MANU:

129451277(eevs)

PDAB:

135769895(eevs)

AMEX:

103021483(eevs)

CMAO:

118808674(eevs)

CHAR:

105909950(eevs)

SPIL:

134092718(eevs)

LCO:

104922196

NCC:

104966975

TBEN:

117475577(eevs)

CGOB:

115008684

PGEO:

117446070(eevs)

GACU:

117543702(eevs)

EMAC:

134883515(eevs)

ELY:	117256564(eevs)

EFO:	125895543(eevs)

PLEP:

121949252(eevs)

SLUC:

116036497(eevs)

ECRA:

117944092(eevs)

ESP:

116687339

PFLV:

114553752

GAT:	120835676(eevs)

PPUG:

119194247(eevs)

AFB:	129105646(eevs)

CLUM:

117730389(eevs)

PSWI:

130208770(eevs)

CANA:

137796649(eevs)

CVE:	137870639(eevs)

MSAM:

119885942(eevs)

SCHU:

122865156(eevs)

CUD:	121507504(eevs)

SPUL:

138606381(eevs)

LMIX:

132977720(eevs)

ALAT:

119021887(eevs)

ASTR:

137595606(eevs)

MZE:

101474077

ONL:

100690451

OAU:	116312421(eevs)

OLA:

101163482

OML:	112144500(eevs)

CSAI:

133449523(eevs)

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122834119(eevs)

PPRL:

129353593(eevs)

CVG:

107082342

CTUL:

119783636(eevs)

GMU:	124857126(eevs)

NFU:

107385806

AOCE:

111566151(eevs)

EJA:	138206998(eevs)

BFRE:

138630233(eevs)

MCEP:

125007449(eevS)

POV:

109629062

SSEN:

122768842(eevs)

SSOE:

131461101(eevs)

HHIP:

117762080(eevs)

HSP:	118104674(eevs)

PPLT:

128456060(eevs)

SMAU:

118309766(eevs)

LCF:	108896951 108898868(eevs)

SDU:

111221586

SLAL:

111663894 111666010

XGL:	120806967(eevs)

BPEC:

110170184

ENY:	140366164(eevs)

BSPL:

114856132(eevs)

SJO:	128356027(eevs)

SSCO:

133978110(eevs)

GMH:

SASA:

STRU:

OTW:

OMY:

OGO:

ONE:

OKI:

OKE:	118389454(eevs)

OMM:

OCLA:

SALP:

SNH:

CCLU:

ELS:

OEP:	134022174(eevs)

SFM:

LOC:

ARUT:

AFRA:

CSL:	COCSUDRAFT_39261

AAF:	AURANDRAFT_3740

SERA:

SERQ:

SLIG:

PALF:

PKQ:	ACEJ41_06035

FSG:	LQ771_06975

RHD:	R2APBS1_3641

RTH:	LRK53_03190

PFC:	PflA506_4591

PEZ:	HWQ56_09190

THAT:

H3N35_23225

TVD:	SG34_025385

PAEW:

KIH87_05110

CJA:

CJA_3250

GPB:	HDN1F_13870(acbC)

CVC:	BKX93_19945

BTZ:

BTL_4163

BOK:

DM82_5622

COF:	FOZ74_00740

MMEI:

LRP31_12225

AVF:	RvVAR031_pl04730(aroB)

MEE:	DA075_19375

SUR:	STAUR_1386(gacC)

AVM:	JQX13_08230 JQX13_41180

CFUS:

PBRU:

PALJ:

PAUU:

TSA:	AciPR4_1231

BBY:	CY96_27945

CBB:

CLD_3207

RPAY:

P0092_07155

MMI:	MMAR_0578(aroB_1)

MMAE:

MMARE11_05350(aroB_1)

MHAD:

B586_06435

MLJ:	MLAC_02190(aroB_1)

CGP:	KBP53_09165

NSR:	NS506_05945

NAH:	F5544_18765

NAD:	NCTC11293_02222(aroB_1)

RER:

RER_54360

REY:

O5Y_25890

REB:	XU06_26170

RHB:

NY08_95

RTM:	G4H71_11885

RHOH:

CPI83_03025

RHS:	A3Q41_04747(aroB_3)

TSM:	ASU32_10315

SRT:

Srot_2448

SHY:

SHJG_0276

SHO:	SHJGH_0110

SALS:

SLNWT_0595

SGU:	SGLAU_01035(gacC)

STRM:

M444_32560

SCZ:	ABE83_10155

SRW:	TUE45_05037(aroB_3)

SLE:	sle_45870(sle_45870)

SCLF:

BB341_29000

SLS:	SLINC_5104

SSIA:

A7J05_03495

SFK:

KY5_0702

SRJ:

SRO_6646

SCYA:

EJ357_02100 EJ357_14575

SAST:

CD934_05045

SNQ:	CP978_00070

SKA:	CP970_39485

SGZ:	C0216_19350

SRK:	FGW37_17500

SFIC:

EIZ62_30660

SSPO:

DDQ41_30765

SGF:	HEP81_06989(gacC)

SPAC:

B1H29_04435

SCYG:

S1361_01415(aroB2)

SAUH:

SU9_022190

SROI:

IAG44_34870

STRY:

EQG64_25575

SGK:	PET44_31000

SCOA:

STPB:

STRV:

SSIR:

KIT:	CFP65_6096

KCH:	O1G21_36190

KCM:	ABWK59_26495

STRH:

GXP74_26630 GXP74_28920

XYA:	ET471_00715

CIRA:

LFM56_12025

AER:	AERYTH_07130

NGV:	CDO52_07210

FAL:

FRAAL4639

AOI:	AORI_5447(aroB)

AJA:	AJAP_35530

AMYC:

CU254_12845

AORI:

SD37_10235

ACOR:

LCL61_18255 LCL61_40685

SESP:

BN6_52640

KUT:	JJ691_27080(salQ)

ACTI:

UA75_21530

ACAD:

UA74_21050

STP:	Strop_2345

SAQ:

Sare_2489

MCAB:

HXZ27_14335

ASE:	ACPL_3680(acbC) ACPL_6250

ACTS:

ACWT_3552 ACWT_6118

PLK:	CIK06_12685

PLAB:

C6361_27335

PLAT:

C6W10_29735

PRY:	Prubr_33290

DROS:

Drose_26960

CWO:

Cwoe_1465

GLP:	Glo7428_0525

GDU:	P0S91_09615

AG:	ABL74381(cetA)

» show all

Reference

PMID:10196166

Authors

Stratmann A, Mahmud T, Lee S, Distler J, Floss HG, Piepersberg W

Title

The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.

Journal

J Biol Chem 274:10889-96 (1999)
DOI:10.1074/jbc.274.16.10889

Sequence

[ase:ACPL_3680]

Reference

PMID:18648803

Authors

Choi WS, Wu X, Choeng YH, Mahmud T, Jeong BC, Lee SH, Chang YK, Kim CJ, Hong SK

Title

Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.

Journal

Appl Microbiol Biotechnol 80:637-45 (2008)
DOI:10.1007/s00253-008-1591-2

Sequence

[sals:SLNWT_0595]

Reference

PMID:24832673

Authors

Kean KM, Codding SJ, Asamizu S, Mahmud T, Karplus PA

Title

Structure of a sedoheptulose 7-phosphate cyclase: ValA from Streptomyces hygroscopicus.

Journal

Biochemistry 53:4250-60 (2014)
DOI:10.1021/bi5003508

Sequence

[shy:SHJG_0276]

Reference

PMID:19101977

Authors

Wu X, Flatt PM, Xu H, Mahmud T

Title

Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.

Journal

Chembiochem 10:304-14 (2009)
DOI:10.1002/cbic.200800527

Sequence

[ag:ABL74381]

All links

Gene (499)   
   MGENES (297)   
   RefGene (195)   
   OC (7)   
All databases (499)   

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