KEGG   ORTHOLOGY: K19974Help
Entry
K19974                      KO                                     

Name
acbO
Definition
2-epi-5-epi-valiolone 7-phosphate 2-epimerase [EC:5.1.3.35]
Pathway
ko00525  Acarbose and validamycin biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00814  Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K19974  acbO; 2-epi-5-epi-valiolone 7-phosphate 2-epimerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.3  Acting on carbohydrates and derivatives
    5.1.3.35  2-epi-5-epi-valiolone 7-phosphate 2-epimerase
     K19974  acbO; 2-epi-5-epi-valiolone 7-phosphate 2-epimerase
BRITE hierarchy
Other DBs
RN: R11081
COG: COG1082
Genes
SERA: Ser39006_003970
SERQ: CWC46_03970
CVC: BKX93_19965
HAS: Halsa_0172
MUL: MUL_0548
MMI: MMAR_0583
MMAE: MMARE11_05400
TSM: ASU32_10290
SALS: SLNWT_0593
SVT: SVTN_01215
SLE: sle_45850(sle_45850)
ACTI: UA75_21520
ACAD: UA74_21040
ASE: ACPL_3679(acbO)
ACTS: ACWT_3551
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Zhang CS, Podeschwa M, Altenbach HJ, Piepersberg W, Wehmeier UF
  Title
The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase.
  Journal
FEBS Lett 540:47-52 (2003)
DOI:10.1016/S0014-5793(03)00221-7
  Sequence
[ase:ACPL_3679]

KEGG   ENZYME: 5.1.3.35Help
Entry
EC 5.1.3.35                 Enzyme                                 

Name
2-epi-5-epi-valiolone 7-phosphate 2-epimerase;
AcbO
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
2-epi-5-epi-valiolone-7-phosphate 2-epimerase
Reaction(IUBMB)
2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate [RN:R11081]
Reaction(KEGG)
Substrate
2-epi-5-epi-valiolone 7-phosphate [CPD:C17692]
Product
5-epi-valiolone 7-phosphate [CPD:C17693]
Comment
The enzyme, isolated from the bacterium Actinoplanes sp. SE 50/110, is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.
History
EC 5.1.3.35 created 2015
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K19974  2-epi-5-epi-valiolone 7-phosphate 2-epimerase
Genes
SERA: Ser39006_003970
SERQ: CWC46_03970
CVC: BKX93_19965
HAS: Halsa_0172
MUL: MUL_0548
MMI: MMAR_0583
MMAE: MMARE11_05400
TSM: ASU32_10290
SALS: SLNWT_0593
SVT: SVTN_01215
SLE: sle_45850(sle_45850)
ACTI: UA75_21520
ACAD: UA74_21040
ASE: ACPL_3679(acbO)
ACTS: ACWT_3551
 » show all
Taxonomy
Reference
1  [PMID:12681481]
  Authors
Zhang CS, Podeschwa M, Altenbach HJ, Piepersberg W, Wehmeier UF
  Title
The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase.
  Journal
FEBS Lett 540:47-52 (2003)
DOI:10.1016/S0014-5793(03)00221-7
  Sequence
[ase:ACPL_3679]
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.35
IUBMB Enzyme Nomenclature: 5.1.3.35
ExPASy - ENZYME nomenclature database: 5.1.3.35
BRENDA, the Enzyme Database: 5.1.3.35

KEGG   REACTION: R11081Help
Entry
R11081                      Reaction                               

Name
2-epi-5-epi-valiolone-7-phosphate 2-epimerase
Definition
2-epi-5-epi-Valiolone 7-phosphate <=> 5-epi-Valiolone 7-phosphate
Equation
Reaction class
RC01519  C17692_C17693
Enzyme
Pathway
rn00525  Acarbose and validamycin biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00814  Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
Orthology
K19974  2-epi-5-epi-valiolone 7-phosphate 2-epimerase [EC:5.1.3.35]
Other DBs
RHEA: 46935

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