KEGG   ORTHOLOGY: K19978Help
Entry
K19978                      KO                                     

Name
acbK
Definition
acarbose 7IV-phosphotransferase [EC:2.7.1.187]
Pathway
ko00525  Acarbose and validamycin biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K19978  acbK; acarbose 7IV-phosphotransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.187  acarbose 7IV-phosphotransferase
     K19978  acbK; acarbose 7IV-phosphotransferase
BRITE hierarchy
Other DBs
RN: R11184
COG: COG0524
Genes
MSX: AU14_17890
HAHE: ENC22_28710
RFO: REIFOR_01851
JAZ: YQ44_16480
JAL: BZG29_11390
JSV: CNX70_11820
SUR: STAUR_1373(gacK)
MBD: MEBOL_002883
PSTE: PSTEL_21445
CBEI: LF65_05135
SFA: Sfla_0297
SHY: SHJG_7630
SVE: SVEN_7113
STRP: F750_6718
SALU: DC74_6799
SALL: SAZ_35315
SGU: SGLAU_01020(gacK)
STRE: GZL_01972
SPRI: SPRI_1871
SRW: TUE45_07278(kdgK_4)
SLE: sle_62240(sle_62240)
SRN: A4G23_05299(kdgK_4)
SLAU: SLA_7384
KSK: KSE_21730
LMOI: VV02_02970
CFI: Celf_2318
NDA: Ndas_3511
NAL: B005_4335
SRO: Sros_3352
KAL: KALB_6123
ALO: CRK60158
ASE: ACPL_1792 ACPL_3675(acbK)
AFS: AFR_34385
CAI: Caci_2113
SNA: Snas_4369
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W
  Title
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
  Journal
J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200
  Sequence
[ase:ACPL_3675]

KEGG   ENZYME: 2.7.1.187Help
Entry
EC 2.7.1.187                Enzyme                                 

Name
acarbose 7IV-phosphotransferase;
acarbose 7-kinase;
AcbK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:acarbose 7IV-phosphotransferase
Reaction(IUBMB)
ATP + acarbose = ADP + acarbose 7IV-phosphate [RN:R11184]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
acarbose [CPD:C06802]
Product
ADP [CPD:C00008];
acarbose 7IV-phosphate [CPD:C21156]
Comment
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose.
History
EC 2.7.1.187 created 2015
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K19978  acarbose 7IV-phosphotransferase
Genes
MSX: AU14_17890
HAHE: ENC22_28710
RFO: REIFOR_01851
JAZ: YQ44_16480
JAL: BZG29_11390
JSV: CNX70_11820
SUR: STAUR_1373(gacK)
MBD: MEBOL_002883
PSTE: PSTEL_21445
CBEI: LF65_05135
SFA: Sfla_0297
SHY: SHJG_7630
SVE: SVEN_7113
STRP: F750_6718
SALU: DC74_6799
SALL: SAZ_35315
SGU: SGLAU_01020(gacK)
STRE: GZL_01972
SPRI: SPRI_1871
SRW: TUE45_07278(kdgK_4)
SLE: sle_62240(sle_62240)
SRN: A4G23_05299(kdgK_4)
SLAU: SLA_7384
KSK: KSE_21730
LMOI: VV02_02970
CFI: Celf_2318
NDA: Ndas_3511
NAL: B005_4335
SRO: Sros_3352
KAL: KALB_6123
ALO: CRK60158
ASE: ACPL_1792 ACPL_3675(acbK)
AFS: AFR_34385
CAI: Caci_2113
SNA: Snas_4369
 » show all
Taxonomy
Reference
1  [PMID:8784428]
  Authors
Drepper A, Pape H
  Title
Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function.
  Journal
J Antibiot (Tokyo) 49:664-8 (1996)
Reference
2  [PMID:8784426]
  Authors
Goeke K, Drepper A, Pape H
  Title
Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp.
  Journal
J Antibiot (Tokyo) 49:661-3 (1996)
Reference
3  [PMID:11937512]
  Authors
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W
  Title
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
  Journal
J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200
  Sequence
[ase:ACPL_3675]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.187
IUBMB Enzyme Nomenclature: 2.7.1.187
ExPASy - ENZYME nomenclature database: 2.7.1.187
BRENDA, the Enzyme Database: 2.7.1.187

KEGG   REACTION: R11184Help
Entry
R11184                      Reaction                               

Name
ATP:acarbose 7IV-phosphotransferase
Definition
ATP + Acarbose <=> ADP + Acarbose 7IV-phosphate
Equation
Reaction class
RC00002  C00002_C00008
RC00017  C06802_C21156
Enzyme
Pathway
rn00525  Acarbose and validamycin biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K19978  acarbose 7IV-phosphotransferase [EC:2.7.1.187]
Other DBs
RHEA: 45127

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