KEGG   ORTHOLOGY: K19979
Entry
K19979                      KO                                     

Name
acbM
Definition
2-epi-5-epi-valiolone 7-kinase [EC:2.7.1.188]
Pathway
ko00525  Acarbose and validamycin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00814  Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K19979  acbM; 2-epi-5-epi-valiolone 7-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.188  2-epi-5-epi-valiolone 7-kinase
     K19979  acbM; 2-epi-5-epi-valiolone 7-kinase
Other DBs
RN: R11185
COG: COG1940
Genes
SERA: Ser39006_003955
SERQ: CWC46_03955
CVC: BKX93_19950
MUL: MUL_0546
MMI: MMAR_0581
MMAE: MMARE11_05380
NSR: NS506_05936
NAH: F5544_18750
NAD: NCTC11293_02223
RER: RER_54460
REY: O5Y_25935
RHB: NY08_86
RHS: A3Q41_04756(nanK_2)
SALS: SLNWT_0590
SRW: TUE45_05036(glcK)
SLE: sle_45860(sle_45860)
SESP: BN6_52650
ACTI: UA75_21505
ACAD: UA74_21025
ASE: ACPL_3676(acbM) ACPL_6249
 » show all
Reference
  Authors
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W
  Title
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
  Journal
J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200
  Sequence
[ase:ACPL_3676]

KEGG   ENZYME: 2.7.1.188
Entry
EC 2.7.1.188                Enzyme                                 

Name
2-epi-5-epi-valiolone 7-kinase;
AcbM
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:2-epi-5-epi-valiolone 7-phosphotransferase
Reaction(IUBMB)
ATP + 2-epi-5-epi-valiolone = ADP + 2-epi-5-epi-valiolone 7-phosphate [RN:R11185]
Reaction(KEGG)
R11185
Substrate
ATP [CPD:C00002];
2-epi-5-epi-valiolone [CPD:C17691]
Product
ADP [CPD:C00008];
2-epi-5-epi-valiolone 7-phosphate [CPD:C17692]
Comment
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose.
History
EC 2.7.1.188 created 2015
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19979  2-epi-5-epi-valiolone 7-kinase
Genes
SERA: Ser39006_003955
SERQ: CWC46_03955
CVC: BKX93_19950
MUL: MUL_0546
MMI: MMAR_0581
MMAE: MMARE11_05380
NSR: NS506_05936
NAH: F5544_18750
NAD: NCTC11293_02223
RER: RER_54460
REY: O5Y_25935
RHB: NY08_86
RHS: A3Q41_04756(nanK_2)
SALS: SLNWT_0590
SRW: TUE45_05036(glcK)
SLE: sle_45860(sle_45860)
SESP: BN6_52650
ACTI: UA75_21505
ACAD: UA74_21025
ASE: ACPL_3676(acbM) ACPL_6249
 » show all
Reference
1  [PMID:11937512]
  Authors
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W
  Title
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
  Journal
J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200
  Sequence
[ase:ACPL_3676]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.188
IUBMB Enzyme Nomenclature: 2.7.1.188
ExPASy - ENZYME nomenclature database: 2.7.1.188
BRENDA, the Enzyme Database: 2.7.1.188

KEGG   REACTION: R11185
Entry
R11185                      Reaction                               

Name
ATP:2-epi-5-epi-valiolone 7-phosphotransferase
Definition
ATP + 2-epi-5-epi-Valiolone <=> ADP + 2-epi-5-epi-Valiolone 7-phosphate
Equation
Reaction class
RC00002  C00002_C00008
RC00017  C17691_C17692
Enzyme
Pathway
rn00525  Acarbose and validamycin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00814  Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
Orthology
K19979  2-epi-5-epi-valiolone 7-kinase [EC:2.7.1.188]

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