KEGG   ORTHOLOGY: K20034
Entry
K20034                      KO                                     

Name
dmdB
Definition
3-(methylthio)propionyl---CoA ligase [EC:6.2.1.44]
Pathway
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K20034  dmdB; 3-(methylthio)propionyl---CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.44  3-(methylthio)propionyl---CoA ligase
     K20034  dmdB; 3-(methylthio)propionyl---CoA ligase
Other DBs
RN: R10820
COG: COG0318
Genes
KPN: KPN_01128
KPU: KP1_2124
KPM: KPHS_20040
KPP: A79E_3102
KPH: KPNIH24_18545
KPZ: KPNIH27_09500
KPV: KPNIH29_10035
KPW: KPNIH30_10510
KPY: KPNIH31_09940
KPG: KPNIH32_10350
KPR: KPR_2171(alkK)
KPJ: N559_3168
KPNU: LI86_16460
KPNK: BN49_2215(alkK)
KVA: Kvar_3252
KPE: KPK_3425
EAE: EAE_16515
EAR: CCG30611
RTG: NCTC13098_04415(fadK)
PSD: DSC_02245
PMY: Pmen_0437
PPB: PPUBIRD1_2436(alkK)
PPX: T1E_5436
PSA: PST_1918(alkK-2)
PSR: PSTAA_1942(alkK-2)
PSTT: CH92_10755
PSEC: CCOS191_3028(alkK1) CCOS191_3233(alkK2)
PSIL: PMA3_18465
PSYC: DABAL43B_1146(alkK1)
ABX: ABK1_2409
ABH: M3Q_2290
ACI: ACIAD1818(alkK)
AGU: AS4_14660(alkK) AS4_18790(alkK)
ILO: IL2156(caiC)
PAT: Patl_1913
MHC: MARHY2843(alkK)
MBS: MRBBS_2254(alkK)
MARJ: MARI_11860(dmdB_2) MARI_17940(dmdB_3)
GPS: C427_1824
SAGA: M5M_04645
ADI: B5T_00426(alkK) B5T_02057
CVI: CV_0898(alkK)
AMAH: DLM_3444
RSO: RSc1749(alkK)
RSC: RCFBP_11758(alkK)
RSL: RPSI07_1790(alkK)
RSN: RSPO_c01785(alkK)
RSM: CMR15_11758(alkK)
RSE: F504_1640
RSY: RSUY_20110(dmdB)
RPI: Rpic_1455
REH: H16_A1519(h16_A1519)
CNC: CNE_1c15500(alkK1) CNE_BB1p08650(alkK2)
RME: Rmet_1863
CGD: CR3_1488
BMA: BMA1439
BMAL: DM55_76
BMAE: DM78_1764
BMAQ: DM76_55
BMAI: DM57_274
BMAF: DM51_1150
BMAZ: BM44_1903
BMAB: BM45_1465
BPS: BPSL1423
BPM: BURPS1710b_2456(alkK)
BPSE: BDL_3501
BPSM: BBQ_1290
BPSU: BBN_1416
BPSD: BBX_1903
BPK: BBK_2918
BPSH: DR55_2538
BPSA: BBU_118
BPSO: X996_2127
BUT: X994_554
BTE: BTH_I2141
BTQ: BTQ_1774
BTJ: BTJ_581
BTZ: BTL_1819
BTV: BTHA_1974
BTHE: BTN_2946
BTHM: BTRA_2102
BTHA: DR62_3092
BTHL: BG87_2045
BOK: DM82_1598
BOC: BG90_3113
BVE: AK36_1978
BCN: Bcen_6172
BCJ: BCAL1980
BCEW: DM40_2507
BCEO: I35_1901
BAM: Bamb_1895
BMJ: BMULJ_01876(alkK)
BMU: Bmul_1367
BMK: DM80_3119
BMUL: NP80_1967
BCT: GEM_1520
BCED: DM42_3193
BDL: AK34_1217
BCON: NL30_13265
BUB: BW23_3084
BLAT: WK25_09265
BTEI: WS51_19920
BSEM: WJ12_09555
BSTG: WT74_09965
BGU: KS03_2336
BGO: BM43_3693
BUK: MYA_1707
BPH: Bphy_1027
PPNO: DA70_02925
PPNM: LV28_03410
PPUL: RO07_22300
PSPU: NA29_14630
PAPI: SG18_21540
CABA: SBC2_18540(dmdB_1) SBC2_52100(dmdB_2) SBC2_69820(dmdB_3)
AXX: ERS451415_05289(fadK_2)
PUT: PT7_0124
AAV: Aave_2946
AJS: Ajs_1678
AAA: Acav_2350
ACRA: BSY15_3194
VEI: Veis_1799
DAC: Daci_3306
CTES: O987_18105
RTA: Rta_20120(alkK)
CBAA: SRAA_1214(alkK)
CBAB: SMCB_1095(alkK)
MPT: Mpe_A1769
CFU: CFU_0847(alkK)
CARE: LT85_0941
TIN: Tint_1283
THI: THI_1605(alkK)
RGE: RGE_39930
AZA: AZKH_1945
HOH: Hoch_4882
PLA: Plav_0799
BJA: bll3856
BBT: BBta_2639(alkK)
BRS: S23_43780
BRAD: BF49_1187
RPE: RPE_4546
XAU: Xaut_0622
MET: M446_2733
RBM: TEF_20745
PZU: PHZ_c0671(alkK)
SIL: SPO2045(dmdB)
PGA: PGA1_c35550(alkK2)
PGL: PGA2_c33750(alkK)
PGD: Gal_03623
PHP: PhaeoP97_03392(alkK2)
PPIC: PhaeoP14_03364(alkK2)
MALG: MALG_00397
RMM: ROSMUCSMR3_02612(dmdB)
MALU: KU6B_41590
HBA: Hbal_2475
SPHK: SKP52_08220(alkK2) SKP52_09175(alkK3) SKP52_13435(alkK4) SKP52_24545(alkK5)
SPHP: LH20_00390
SMAZ: LH19_18490
SGI: SGRAN_1960(alkK4) SGRAN_4016
SPHU: SPPYR_0348 SPPYR_1840(alkK)
SWI: Swit_2237
SPHD: HY78_22860
SPHM: G432_07400
SSAN: NX02_11945
SFLA: SPHFLASMR4Y_01070(prpE)
ACR: Acry_1426
SHUM: STHU_19510
RRU: Rru_A1316
RRF: F11_06805
RCE: RC1_3286(alkK)
ALI: AZOLI_p50188(alkK)
TMO: TMO_0639(alkK) TMO_1913(alkK)
CVA: CVAR_2642(fadD12)
CTER: A606_11105
HSW: Hsw_1033
 » show all
Reference
  Authors
Reisch CR, Stoudemayer MJ, Varaljay VA, Amster IJ, Moran MA, Whitman WB
  Title
Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria.
  Journal
Nature 473:208-11 (2011)
DOI:10.1038/nature10078
  Sequence
[sil:SPO2045]

KEGG   ENZYME: 6.2.1.44
Entry
EC 6.2.1.44                 Enzyme                                 

Name
3-(methylthio)propionyl---CoA ligase;
DmdB;
MMPA-CoA ligase;
methylmercaptopropionate-coenzyme A ligase;
3-methylmercaptopropionyl-CoA ligase;
3-(methylthio)propanoate:CoA ligase (AMP-forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
3-(methylsulfanyl)propanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 3-(methylsulfanyl)propanoate + CoA = AMP + diphosphate + 3-(methylsulfanyl)propanoyl-CoA [RN:R10820]
Reaction(KEGG)
R10820
Substrate
ATP [CPD:C00002];
3-(methylsulfanyl)propanoate [CPD:C08276];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
3-(methylsulfanyl)propanoyl-CoA [CPD:C20870]
Comment
The enzyme is part of a dimethylsulfoniopropanoate demethylation pathway in the marine bacteria Ruegeria pomeroyi and Pelagibacter ubique. It also occurs in some nonmarine bacteria capable of metabolizing dimethylsulfoniopropionate (e.g. Burkholderia thailandensis, Pseudomonas aeruginosa, and Silicibacter lacuscaerulensis). It requires Mg2+ [2].
History
EC 6.2.1.44 created 2014
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
Orthology
K20034  3-(methylthio)propionyl---CoA ligase
Genes
KPN: KPN_01128
KPU: KP1_2124
KPM: KPHS_20040
KPP: A79E_3102
KPH: KPNIH24_18545
KPZ: KPNIH27_09500
KPV: KPNIH29_10035
KPW: KPNIH30_10510
KPY: KPNIH31_09940
KPG: KPNIH32_10350
KPR: KPR_2171(alkK)
KPJ: N559_3168
KPNU: LI86_16460
KPNK: BN49_2215(alkK)
KVA: Kvar_3252
KPE: KPK_3425
EAE: EAE_16515
EAR: CCG30611
RTG: NCTC13098_04415(fadK)
PSD: DSC_02245
PMY: Pmen_0437
PPB: PPUBIRD1_2436(alkK)
PPX: T1E_5436
PSA: PST_1918(alkK-2)
PSR: PSTAA_1942(alkK-2)
PSTT: CH92_10755
PSEC: CCOS191_3028(alkK1) CCOS191_3233(alkK2)
PSIL: PMA3_18465
PSYC: DABAL43B_1146(alkK1)
ABX: ABK1_2409
ABH: M3Q_2290
ACI: ACIAD1818(alkK)
AGU: AS4_14660(alkK) AS4_18790(alkK)
ILO: IL2156(caiC)
PAT: Patl_1913
MHC: MARHY2843(alkK)
MBS: MRBBS_2254(alkK)
MARJ: MARI_11860(dmdB_2) MARI_17940(dmdB_3)
GPS: C427_1824
SAGA: M5M_04645
ADI: B5T_00426(alkK) B5T_02057
CVI: CV_0898(alkK)
AMAH: DLM_3444
RSO: RSc1749(alkK)
RSC: RCFBP_11758(alkK)
RSL: RPSI07_1790(alkK)
RSN: RSPO_c01785(alkK)
RSM: CMR15_11758(alkK)
RSE: F504_1640
RSY: RSUY_20110(dmdB)
RPI: Rpic_1455
REH: H16_A1519(h16_A1519)
CNC: CNE_1c15500(alkK1) CNE_BB1p08650(alkK2)
RME: Rmet_1863
CGD: CR3_1488
BMA: BMA1439
BMAL: DM55_76
BMAE: DM78_1764
BMAQ: DM76_55
BMAI: DM57_274
BMAF: DM51_1150
BMAZ: BM44_1903
BMAB: BM45_1465
BPS: BPSL1423
BPM: BURPS1710b_2456(alkK)
BPSE: BDL_3501
BPSM: BBQ_1290
BPSU: BBN_1416
BPSD: BBX_1903
BPK: BBK_2918
BPSH: DR55_2538
BPSA: BBU_118
BPSO: X996_2127
BUT: X994_554
BTE: BTH_I2141
BTQ: BTQ_1774
BTJ: BTJ_581
BTZ: BTL_1819
BTV: BTHA_1974
BTHE: BTN_2946
BTHM: BTRA_2102
BTHA: DR62_3092
BTHL: BG87_2045
BOK: DM82_1598
BOC: BG90_3113
BVE: AK36_1978
BCN: Bcen_6172
BCJ: BCAL1980
BCEW: DM40_2507
BCEO: I35_1901
BAM: Bamb_1895
BMJ: BMULJ_01876(alkK)
BMU: Bmul_1367
BMK: DM80_3119
BMUL: NP80_1967
BCT: GEM_1520
BCED: DM42_3193
BDL: AK34_1217
BCON: NL30_13265
BUB: BW23_3084
BLAT: WK25_09265
BTEI: WS51_19920
BSEM: WJ12_09555
BSTG: WT74_09965
BGU: KS03_2336
BGO: BM43_3693
BUK: MYA_1707
BPH: Bphy_1027
PPNO: DA70_02925
PPNM: LV28_03410
PPUL: RO07_22300
PSPU: NA29_14630
PAPI: SG18_21540
CABA: SBC2_18540(dmdB_1) SBC2_52100(dmdB_2) SBC2_69820(dmdB_3)
AXX: ERS451415_05289(fadK_2)
PUT: PT7_0124
AAV: Aave_2946
AJS: Ajs_1678
AAA: Acav_2350
ACRA: BSY15_3194
VEI: Veis_1799
DAC: Daci_3306
CTES: O987_18105
RTA: Rta_20120(alkK)
CBAA: SRAA_1214(alkK)
CBAB: SMCB_1095(alkK)
MPT: Mpe_A1769
CFU: CFU_0847(alkK)
CARE: LT85_0941
TIN: Tint_1283
THI: THI_1605(alkK)
RGE: RGE_39930
AZA: AZKH_1945
HOH: Hoch_4882
PLA: Plav_0799
BJA: bll3856
BBT: BBta_2639(alkK)
BRS: S23_43780
BRAD: BF49_1187
RPE: RPE_4546
XAU: Xaut_0622
MET: M446_2733
RBM: TEF_20745
PZU: PHZ_c0671(alkK)
SIL: SPO2045(dmdB)
PGA: PGA1_c35550(alkK2)
PGL: PGA2_c33750(alkK)
PGD: Gal_03623
PHP: PhaeoP97_03392(alkK2)
PPIC: PhaeoP14_03364(alkK2)
MALG: MALG_00397
RMM: ROSMUCSMR3_02612(dmdB)
MALU: KU6B_41590
HBA: Hbal_2475
SPHK: SKP52_08220(alkK2) SKP52_09175(alkK3) SKP52_13435(alkK4) SKP52_24545(alkK5)
SPHP: LH20_00390
SMAZ: LH19_18490
SGI: SGRAN_1960(alkK4) SGRAN_4016
SPHU: SPPYR_0348 SPPYR_1840(alkK)
SWI: Swit_2237
SPHD: HY78_22860
SPHM: G432_07400
SSAN: NX02_11945
SFLA: SPHFLASMR4Y_01070(prpE)
ACR: Acry_1426
SHUM: STHU_19510
RRU: Rru_A1316
RRF: F11_06805
RCE: RC1_3286(alkK)
ALI: AZOLI_p50188(alkK)
TMO: TMO_0639(alkK) TMO_1913(alkK)
CVA: CVAR_2642(fadD12)
CTER: A606_11105
HSW: Hsw_1033
 » show all
Reference
1  [PMID:21562561]
  Authors
Reisch CR, Stoudemayer MJ, Varaljay VA, Amster IJ, Moran MA, Whitman WB
  Title
Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria.
  Journal
Nature 473:208-11 (2011)
DOI:10.1038/nature10078
  Sequence
[sil:SPO2045]
Reference
2  [PMID:24443527]
  Authors
Bullock HA, Reisch CR, Burns AS, Moran MA, Whitman WB
  Title
Regulatory and functional diversity of methylmercaptopropionate coenzyme A ligases from the dimethylsulfoniopropionate demethylation pathway in Ruegeria pomeroyi DSS-3 and other proteobacteria.
  Journal
J Bacteriol 196:1275-85 (2014)
DOI:10.1128/JB.00026-14
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.44
IUBMB Enzyme Nomenclature: 6.2.1.44
ExPASy - ENZYME nomenclature database: 6.2.1.44
BRENDA, the Enzyme Database: 6.2.1.44

KEGG   REACTION: R10820
Entry
R10820                      Reaction                               

Name
3-(methylthio)propanoate:CoA ligase (AMP-forming)
Definition
ATP + 3-(Methylthio)propanoate + CoA <=> AMP + Diphosphate + 3-(Methylthio)propanoyl-CoA
Equation
Reaction class
RC00004  C00010_C20870
RC00014  C08276_C20870
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
Orthology
K20034  3-(methylthio)propionyl---CoA ligase [EC:6.2.1.44]
Other DBs
RHEA: 43055

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