KEGG   ORTHOLOGY: K20077Help
Entry
K20077                      KO                                     

Name
staC
Definition
flavin-dependent monooxygenase StaC [EC:1.13.12.-]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00805  Staurosporine biosynthesis, tryptophan => staurosporine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K20077  staC; flavin-dependent monooxygenase StaC
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.-  
     K20077  staC; flavin-dependent monooxygenase StaC
BRITE hierarchy
Other DBs
RN: R11121
COG: COG0654
Genes
SRN: A4G23_00555(tfdB)
SCLF: BB341_29635
SAQ: Sare_2333
AG: BAF47693(staC)
TaxonomyKoalaUniProt
Reference
  Authors
Howard-Jones AR, Walsh CT
  Title
Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid.
  Journal
J Am Chem Soc 128:12289-98 (2006)
DOI:10.1021/ja063898m
  Sequence

KEGG   ORTHOLOGY: K20078Help
Entry
K20078                      KO                                     

Name
staP
Definition
cytochrome P450 StaP [EC:1.13.12.-]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00805  Staurosporine biosynthesis, tryptophan => staurosporine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K20078  staP; cytochrome P450 StaP
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.-  
     K20078  staP; cytochrome P450 StaP
BRITE hierarchy
Other DBs
RN: R11121
COG: COG2124
Genes
SRN: A4G23_00558(bioI_2)
SCLF: BB341_29670
SAQ: Sare_2331
AG: BAC55212(staP)
TaxonomyKoalaUniProt
Reference
  Authors
Makino M, Sugimoto H, Shiro Y, Asamizu S, Onaka H, Nagano S
  Title
Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton.
  Journal
Proc Natl Acad Sci U S A 104:11591-6 (2007)
DOI:10.1073/pnas.0702946104
  Sequence

KEGG   REACTION: R11121Help
Entry
R11121                      Reaction                               

Definition
Chromopyrrolate + 2 Oxygen + 2 NADH + 3 H+ <=> K-252c + 2 CO2 + 3 H2O + 2 NAD+
Equation
C21125 + 2 C00007 + 2 C00004 + 3 C00080 <=> C21126 + 2 C00011 + 3 C00001 + 2 C00003
Reaction class
RC00001  C00003_C00004
RC03361  C21125_C21126
Enzyme
1.13.12.-
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00805  Staurosporine biosynthesis, tryptophan => staurosporine
Orthology
K20077  flavin-dependent monooxygenase StaC [EC:1.13.12.-]
K20078  cytochrome P450 StaP [EC:1.13.12.-]

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