KEGG   ORTHOLOGY: K20082Help
Entry
K20082                      KO                                     

Name
staMB
Definition
O-methyltransferase StaMB [EC:2.1.1.139]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00805  Staurosporine biosynthesis, tryptophan => staurosporine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K20082  staMB; O-methyltransferase StaMB
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.139  3'-demethylstaurosporine O-methyltransferase
     K20082  staMB; O-methyltransferase StaMB
BRITE hierarchy
Other DBs
RN: R05757
GO: 0030793
Genes
SRN: A4G23_00556(rebM_1)
SCLF: BB341_29640
SAQ: Sare_2332
AG: BAC55218(staMB)
TaxonomyKoalaUniProt
Reference
  Authors
Salas AP, Zhu L, Sanchez C, Brana AF, Rohr J, Mendez C, Salas JA
  Title
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase.
  Journal
Mol Microbiol 58:17-27 (2005)
DOI:10.1111/j.1365-2958.2005.04777.x
  Sequence

KEGG   ENZYME: 2.1.1.139Help
Entry
EC 2.1.1.139                Enzyme                                 

Name
3'-demethylstaurosporine O-methyltransferase;
3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase;
staurosporine synthase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine [RN:R05757]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3'-demethylstaurosporine [CPD:C07349]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
staurosporine [CPD:C02079]
Comment
Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.
History
EC 2.1.1.139 created 2000
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K20082  O-methyltransferase StaMB
Genes
SRN: A4G23_00556(rebM_1)
SCLF: BB341_29640
SAQ: Sare_2332
Taxonomy
Reference
1  [PMID:9727395]
  Authors
Weidner S, Kittelmann M, Goeke K, Ghisalba O, Zahner H.
  Title
3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine.
  Journal
J Antibiot (Tokyo) 51:679-82 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.139
IUBMB Enzyme Nomenclature: 2.1.1.139
ExPASy - ENZYME nomenclature database: 2.1.1.139
BRENDA, the Enzyme Database: 2.1.1.139
CAS: 212906-74-6

KEGG   REACTION: R05757Help
Entry
R05757                      Reaction                               

Name
S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase
Definition
S-Adenosyl-L-methionine + 3'-Demethylstaurosporine <=> S-Adenosyl-L-homocysteine + Staurosporine
Equation
Reaction class
RC00003  C00019_C00021
RC00466  C02079_C07349
Enzyme
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00805  Staurosporine biosynthesis, tryptophan => staurosporine
Orthology
K20082  O-methyltransferase StaMB [EC:2.1.1.139]
Other DBs
RHEA: 11699

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