Entry |
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Name |
violacein synthase;
proviolaceinate monooxygenase;
vioC (gene name)
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Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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Sysname |
protoviolaceinate,NAD(P)H:O2 oxidoreductase
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Reaction(IUBMB) |
(1) protoviolaceinate + NAD(P)H + O2 = violaceinate + NAD(P)+ + H2O [RN: R11135 R11373];
(2) protodeoxyviolaceinate + NAD(P)H + O2 = deoxyviolaceinate + NAD(P)+ + H2O [RN: R11132 R11374]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme, characterized from the bacterium Chromobacterium violaceum, participates in the biosynthesis of the violet pigment violacein. The products, violaceinate and deoxyviolaceinate, undergo non-enzymic autooxidation into violacein and deoxyviolacein, respectively.
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History |
EC 1.14.13.224 created 2016
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Pathway |
ec01130 | Biosynthesis of antibiotics |
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Orthology |
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Genes |
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Reference |
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Authors |
Balibar CJ, Walsh CT |
Title |
In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum. |
Journal |
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Reference |
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Authors |
Shinoda K, Hasegawa T, Sato H, Shinozaki M, Kuramoto H, Takamiya Y, Sato T, Nikaidou N, Watanabe T, Hoshino T. |
Title |
Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function. |
Journal |
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Sequence |
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Other DBs |
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