KEGG ORTHOLOGY: K20158

ORTHOLOGY: K20158

Entry

K20158 KO

Name

pao

Definition

pseudooxynicotine oxidase [EC:1.4.3.24]

Pathway

ko00760

Nicotinate and nicotinamide metabolism

ko01100

Metabolic pathways

ko01120

Microbial metabolism in diverse environments

Module

M00811

Nicotine degradation, pyrrolidine pathway, nicotine => succinate semialdehyde

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K20158  pao; pseudooxynicotine oxidase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.3  With oxygen as acceptor
    1.4.3.24  pseudooxynicotine oxidase
     K20158  pao; pseudooxynicotine oxidase

Other DBs

RN:

R10103

COG:

COG1231

Genes

PPT:

PPS_4080

PMON:

X969_19990

PMOT:

X970_19625

AG:	AFD54463(pao)

Reference

PMID:22267672

Authors

Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W

Title

Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine.

Journal

Appl Environ Microbiol 78:2154-60 (2012)
DOI:10.1128/AEM.07025-11

Sequence

[ag:AFD54463]

ENZYME: 1.4.3.24

Entry

EC 1.4.3.24 Enzyme

Name

pseudooxynicotine oxidase

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor

Sysname

4-(methylamino)-1-(pyridin-3-yl)butan-1-one:oxygen oxidoreductase (methylamine releasing)

Reaction(IUBMB)

4-(methylamino)-1-(pyridin-3-yl)butan-1-one + H2O + O2 = 4-oxo-4-(pyridin-3-yl)butanal + methylamine + H2O2 [RN:R10103]

Reaction(KEGG)

R10103

Substrate

4-(methylamino)-1-(pyridin-3-yl)butan-1-one [CPD:C20361];
H2O [CPD:C00001];
O2 [CPD:C00007]

Product

4-oxo-4-(pyridin-3-yl)butanal [CPD:C19567];
methylamine [CPD:C00218];
H2O2 [CPD:C00027]

Comment

Contains one non-covalently bound FAD molecule per dimer. This enzyme, characterized from the soil bacterium Pseudomonas sp. HZN6, is involved the nicotine degradation.

History

EC 1.4.3.24 created 2012

Pathway

ec00760

Nicotinate and nicotinamide metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K20158

pseudooxynicotine oxidase

Genes

PPT:

PPS_4080

PMON:

X969_19990

PMOT:

X970_19625

Reference

1 [PMID:22267672]

Authors

Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W

Title

Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine.

Journal

Appl Environ Microbiol 78:2154-60 (2012)
DOI:10.1128/AEM.07025-11

Sequence

[ag:AFD54463]

Other DBs

ExplorEnz - The Enzyme Database:

1.4.3.24

IUBMB Enzyme Nomenclature:

1.4.3.24

ExPASy - ENZYME nomenclature database:

1.4.3.24

BRENDA, the Enzyme Database:

1.4.3.24

REACTION: R10103

Entry

R10103 Reaction

Name

4-(methylamino)-1-(pyridin-3-yl)butan-1-one:oxygen oxidoreductase (methylamine releasing)

Definition

Pseudooxynicotine + H2O + Oxygen <=> 4-Oxo-1-(3-pyridyl)-1-butanone + Methylamine + Hydrogen peroxide

Equation

C20361 + C00001 + C00007 <=> C19567 + C00218 + C00027

Reaction class

RC00225

C19567_C20361

RC00807

C00218_C20361

RC02755

C00007_C00027

Enzyme

1.4.3.24

Pathway

rn00760

Nicotinate and nicotinamide metabolism

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

Module

M00811

Nicotine degradation, pyrrolidine pathway, nicotine => succinate semialdehyde

Orthology

K20158

pseudooxynicotine oxidase [EC:1.4.3.24]

Other DBs

RHEA:

33906

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (4)   
All databases (23)   

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