KEGG   ORTHOLOGY: K20261Help
Entry
K20261                      KO                                     

Name
phzD
Definition
trans-2,3-dihydro-3-hydroxyanthranilic acid synthase [EC:3.3.2.15]
Pathway
ko00405  Phenazine biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
ko02024  Quorum sensing
Module
M00835  Pyocyanine biosynthesis, chorismate => pyocyanine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00405 Phenazine biosynthesis
    K20261  phzD; trans-2,3-dihydro-3-hydroxyanthranilic acid synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K20261  phzD; trans-2,3-dihydro-3-hydroxyanthranilic acid synthase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.15  trans-2,3-dihydro-3-hydroxyanthranilic acid synthase
     K20261  phzD; trans-2,3-dihydro-3-hydroxyanthranilic acid synthase
BRITE hierarchy
Other DBs
RN: R11463
COG: COG1535
Genes
SFW: WN53_03390
PATR: EV46_13200
PATO: GZ59_18580(ehpB)
LAB: LA76x_3334(phzD1)
LAQ: GLA29479_2367(phzD1)
PAE: PA1902(phzD2) PA4213(phzD1)
PAEV: N297_1962 N297_4345
PAEI: N296_1962 N296_4345
PAU: PA14_09450(phzD1)
PAP: PSPA7_0886 PSPA7_3382
PAG: PLES_07141(phzD1) PLES_34221(phzD2)
PAF: PAM18_0724(phzD1) PAM18_3140(phzD2)
PAEU: BN889_06463(phzD1_1) BN889_06723(phzD1_2) BN889_06777(phzD1_3) BN889_06963(phzD1_4) BN889_06967(phzD1_5) BN889_07359(phzD1_6)
PFB: VO64_0337
PSET: THL1_3621
BGU: KS03_4992
BVR: BVIR_2863
MAB: MAB_0297
MABB: MASS_0298
MCHE: BB28_01465
MSAL: DSM43276_00252(phzD_1)
RHS: A3Q41_02711(phzD)
SALB: XNR_0597
SALS: SLNWT_4919
SGU: SGLAU_17220(phzA)
STRM: M444_18420
SRN: A4G23_05417(phzD)
STRD: NI25_24440
NDA: Ndas_5030
NAL: B005_4272(dhbB)
STRR: EKD16_18440(phzD)
ALO: CRK58740
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8586283
  Authors
Pierson LS 3rd, Gaffney T, Lam S, Gong F
  Title
Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacterium. Pseudomonas aureofaciens 30-84.
  Journal
FEMS Microbiol Lett 134:299-307 (1995)
DOI:10.1111/j.1574-6968.1995.tb07954.x

KEGG   ENZYME: 3.3.2.15Help
Entry
EC 3.3.2.15                 Enzyme                                 

Name
trans-2,3-dihydro-3-hydroxyanthranilic acid synthase;
isochorismatase (ambiguous);
phzD (gene name)
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
BRITE hierarchy
Sysname
(2S)-2-amino-4-deoxychorismate pyruvate-hydrolase
Reaction(IUBMB)
(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate [RN:R11463]
Reaction(KEGG)
Substrate
(2S)-2-amino-4-deoxychorismate [CPD:C18054];
H2O [CPD:C00001]
Product
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate [CPD:C19830];
pyruvate [CPD:C00022]
Comment
Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis.
History
EC 3.3.2.15 created 2016
Pathway
ec00405  Phenazine biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K20261  trans-2,3-dihydro-3-hydroxyanthranilic acid synthase
Genes
SFW: WN53_03390
PATR: EV46_13200
PATO: GZ59_18580(ehpB)
LAB: LA76x_3334(phzD1)
LAQ: GLA29479_2367(phzD1)
PAE: PA1902(phzD2) PA4213(phzD1)
PAEV: N297_1962 N297_4345
PAEI: N296_1962 N296_4345
PAU: PA14_09450(phzD1)
PAP: PSPA7_0886 PSPA7_3382
PAG: PLES_07141(phzD1) PLES_34221(phzD2)
PAF: PAM18_0724(phzD1) PAM18_3140(phzD2)
PAEU: BN889_06463(phzD1_1) BN889_06723(phzD1_2) BN889_06777(phzD1_3) BN889_06963(phzD1_4) BN889_06967(phzD1_5) BN889_07359(phzD1_6)
PFB: VO64_0337
PSET: THL1_3621
BGU: KS03_4992
BVR: BVIR_2863
MAB: MAB_0297
MABB: MASS_0298
MCHE: BB28_01465
MSAL: DSM43276_00252(phzD_1)
RHS: A3Q41_02711(phzD)
SALB: XNR_0597
SALS: SLNWT_4919
SGU: SGLAU_17220(phzA)
STRM: M444_18420
SRN: A4G23_05417(phzD)
STRD: NI25_24440
NDA: Ndas_5030
NAL: B005_4272(dhbB)
STRR: EKD16_18440(phzD)
ALO: CRK58740
 » show all
Taxonomy
Reference
1  [PMID:11591691]
  Authors
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS
  Title
Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
  Journal
J Bacteriol 183:6454-65 (2001)
DOI:10.1128/JB.183.21.6454-6465.2001
  Sequence
Reference
2  [PMID:12741825]
  Authors
Parsons JF, Calabrese K, Eisenstein E, Ladner JE
  Title
Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway.
  Journal
Biochemistry 42:5684-93 (2003)
DOI:10.1021/bi027385d
  Sequence
[pae:PA1902]
Other DBs
ExplorEnz - The Enzyme Database: 3.3.2.15
IUBMB Enzyme Nomenclature: 3.3.2.15
ExPASy - ENZYME nomenclature database: 3.3.2.15
BRENDA, the Enzyme Database: 3.3.2.15

KEGG   REACTION: R11463Help
Entry
R11463                      Reaction                               

Name
(2S)-2-amino-4-deoxychorismate pyruvate-hydrolase
Definition
2-Amino-2-deoxyisochorismate + H2O <=> (5S,6S)-6-Amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + Pyruvate
Equation
Reaction class
RC00350  C18054_C19830
Enzyme
Pathway
rn00405  Phenazine biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00835  Pyocyanine biosynthesis, chorismate => pyocyanine
Orthology
K20261  trans-2,3-dihydro-3-hydroxyanthranilic acid synthase [EC:3.3.2.15]

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