KEGG   ORTHOLOGY: K20262Help
Entry
K20262                      KO                                     

Name
phzG
Definition
dihydrophenazinedicarboxylate synthase [EC:1.10.3.16]
Pathway
ko00405  Phenazine biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
ko02024  Quorum sensing
Module
M00835  Pyocyanine biosynthesis, chorismate => pyocyanine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00405 Phenazine biosynthesis
    K20262  phzG; dihydrophenazinedicarboxylate synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K20262  phzG; dihydrophenazinedicarboxylate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.10  Acting on diphenols and related substances as donors
   1.10.3  With oxygen as acceptor
    1.10.3.16  dihydrophenazinedicarboxylate synthase
     K20262  phzG; dihydrophenazinedicarboxylate synthase
BRITE hierarchy
Other DBs
RN: R11489 R11490 R11491 R11492
COG: COG0259
Genes
SFW: WN53_03370
ECA: ECA2698(ehpE)
PATR: EV46_13180
PATO: GZ59_18620(ehpE)
LAB: LA76x_3331(phzG)
LAQ: GLA29479_2364(phzG)
PAE: PA1905(phzG2) PA4216(phzG1)
PAEV: N297_1965(pdxH) N297_4348(pdxH)
PAEI: N296_1965(pdxH) N296_4348(pdxH)
PAU: PA14_09410(phzG1) PA14_39880(phzG2)
PAP: PSPA7_0883 PSPA7_3379
PAG: PLES_07111(phzG1) PLES_34191(phzG2)
PAF: PAM18_0721(phzG1) PAM18_3137(phzG2)
PNC: NCGM2_2822(phzG1) NCGM2_5461(phzG1)
PAEB: NCGM1900_0743(phzG1) NCGM1900_4584(phzG1)
PDK: PADK2_03590 PADK2_16120
PSG: G655_03625 G655_15590
PRP: M062_09945 M062_22210
PAEP: PA1S_03740 PA1S_16415
PAER: PA1R_gp2107 PA1R_gp5534
PAEM: U769_03770 U769_16130
PAEL: T223_03675 T223_17475
PAES: SCV20265_0745 SCV20265_3490
PAEU: BN889_04687(phzG2_1) BN889_06679(phzG2_2)
PAEG: AI22_00170 AI22_17575
PAEC: M802_1963(pdxH) M802_4346(pdxH)
PAEO: M801_1964(pdxH) M801_4214(pdxH)
PFB: VO64_0340
POI: BOP93_12290
PCH: EY04_26300
PCP: JM49_05445
PYM: AK972_2559
BUU: WS70_27195
BUR: Bcep18194_B1572
BGL: bglu_2g09280
BGU: KS03_4989(phzG)
RER: RER_pREL1-02980
SALS: SLNWT_0234
STRC: AA958_30785
STRD: NI25_24415
SNW: BBN63_05600
CUM: NI26_14645
CUB: BJK06_09775
SALC: C2138_10050(pdxH)
SALD: FVA74_10700(pdxH)
BRI: FDF13_09775(pdxH)
NDA: Ndas_5033
NOA: BKM31_19735
APRE: CNX65_16905(pdxH)
ACTA: C1701_23220(pdxH)
ALO: CRK58743
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS
  Title
Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
  Journal
J Bacteriol 183:6454-65 (2001)
DOI:10.1128/JB.183.21.6454-6465.2001
  Sequence
[pae:PA4216]
Reference
  Authors
Xu N, Ahuja EG, Janning P, Mavrodi DV, Thomashow LS, Blankenfeldt W
  Title
Trapped intermediates in crystals of the FMN-dependent oxidase PhzG provide insight into the final steps of phenazine biosynthesis.
  Journal
Acta Crystallogr D Biol Crystallogr 69:1403-13 (2013)
DOI:10.1107/S0907444913008354

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Pathway (9)   
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Chemical reaction (7)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
   KEGG RCLASS (2)   
Gene (77)   
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KEGG   ENZYME: 1.10.3.16Help
Entry
EC 1.10.3.16                Enzyme                                 

Name
dihydrophenazinedicarboxylate synthase;
phzG (gene name)
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
1,4,5a,6,9,10a-hexahydrophenazine-1,6-dicarboxylate:oxygen oxidoreductase
Reaction(IUBMB)
(1) (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2 [RN:R11489];
(2) (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2 [RN:R11490];
(3) (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 [RN:R11491];
(4) (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-5,10-dihydrophenazine-1-carboxylate + H2O2
Reaction(KEGG)
Substrate
(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate [CPD:C21408];
O2 [CPD:C00007];
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate [CPD:C21409];
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate [CPD:C21411];
(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate [CPD:C21413]
Product
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate [CPD:C21409];
H2O2 [CPD:C00027];
(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate [CPD:C21410];
(10aS)-10,10a-dihydrophenazine-1-carboxylate [CPD:C21412];
(10aS)-5,10-dihydrophenazine-1-carboxylate
Comment
Requires FMN. The enzyme, isolated from the bacteria Pseudomonas fluorescens 2-79 and Burkholderia lata 383, is involved in biosynthesis of the reduced forms of phenazine, phenazine-1-carboxylate, and phenazine-1,6-dicarboxylate, where it catalyses multiple reactions.
History
EC 1.10.3.16 created 2016
Pathway
ec00405  Phenazine biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K20262  dihydrophenazinedicarboxylate synthase
Genes
SFW: WN53_03370
ECA: ECA2698(ehpE)
PATR: EV46_13180
PATO: GZ59_18620(ehpE)
LAB: LA76x_3331(phzG)
LAQ: GLA29479_2364(phzG)
PAE: PA1905(phzG2) PA4216(phzG1)
PAEV: N297_1965(pdxH) N297_4348(pdxH)
PAEI: N296_1965(pdxH) N296_4348(pdxH)
PAU: PA14_09410(phzG1) PA14_39880(phzG2)
PAP: PSPA7_0883 PSPA7_3379
PAG: PLES_07111(phzG1) PLES_34191(phzG2)
PAF: PAM18_0721(phzG1) PAM18_3137(phzG2)
PNC: NCGM2_2822(phzG1) NCGM2_5461(phzG1)
PAEB: NCGM1900_0743(phzG1) NCGM1900_4584(phzG1)
PDK: PADK2_03590 PADK2_16120
PSG: G655_03625 G655_15590
PRP: M062_09945 M062_22210
PAEP: PA1S_03740 PA1S_16415
PAER: PA1R_gp2107 PA1R_gp5534
PAEM: U769_03770 U769_16130
PAEL: T223_03675 T223_17475
PAES: SCV20265_0745 SCV20265_3490
PAEU: BN889_04687(phzG2_1) BN889_06679(phzG2_2)
PAEG: AI22_00170 AI22_17575
PAEC: M802_1963(pdxH) M802_4346(pdxH)
PAEO: M801_1964(pdxH) M801_4214(pdxH)
PFB: VO64_0340
POI: BOP93_12290
PCH: EY04_26300
PCP: JM49_05445
PYM: AK972_2559
BUU: WS70_27195
BUR: Bcep18194_B1572
BGL: bglu_2g09280
BGU: KS03_4989(phzG)
RER: RER_pREL1-02980
SALS: SLNWT_0234
STRC: AA958_30785
STRD: NI25_24415
SNW: BBN63_05600
CUM: NI26_14645
CUB: BJK06_09775
SALC: C2138_10050(pdxH)
SALD: FVA74_10700(pdxH)
BRI: FDF13_09775(pdxH)
NDA: Ndas_5033
NOA: BKM31_19735
APRE: CNX65_16905(pdxH)
ACTA: C1701_23220(pdxH)
ALO: CRK58743
 » show all
Taxonomy
Reference
1  [PMID:23897464]
  Authors
Xu N, Ahuja EG, Janning P, Mavrodi DV, Thomashow LS, Blankenfeldt W
  Title
Trapped intermediates in crystals of the FMN-dependent oxidase PhzG provide insight into the final steps of phenazine biosynthesis.
  Journal
Acta Crystallogr D Biol Crystallogr 69:1403-13 (2013)
DOI:10.1107/S0907444913008354
Other DBs
ExplorEnz - The Enzyme Database: 1.10.3.16
IUBMB Enzyme Nomenclature: 1.10.3.16
ExPASy - ENZYME nomenclature database: 1.10.3.16
BRENDA, the Enzyme Database: 1.10.3.16

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Chemical substance (9)   
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Chemical reaction (6)   
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Gene (75)   
   KEGG ORTHOLOGY (1)   
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DNA sequence (2)   
   GenBank (1)   
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All databases (99)   

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KEGG   REACTION: R11492Help
Entry
R11492                      Reaction                               

Name
(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate:oxygen oxidoreductase
Definition
(1R)-1,4,5,10-Tetrahydrophenazine-1-carboxylate + Oxygen <=> 5,10-Dihydrophenazine-1-carboxylate + Hydrogen peroxide
Equation
Reaction class
RC03450  C20981_C21413
Enzyme
Pathway
rn00405  Phenazine biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K20262  dihydrophenazinedicarboxylate synthase [EC:1.10.3.16]
Other DBs
RHEA: 49963

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (73)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (72)   
All databases (84)   

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