KEGG   ORTHOLOGY: K20427Help
Entry
K20427                      KO                                     

Name
acbR, vldB
Definition
valienol-1-phosphate guanylyltransferase [EC:2.7.7.91]
Pathway
ko00525  Acarbose and validamycin biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00814  Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K20427  acbR, vldB; valienol-1-phosphate guanylyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.91  valienol-1-phosphate guanylyltransferase
     K20427  acbR, vldB; valienol-1-phosphate guanylyltransferase
BRITE hierarchy
Other DBs
RN: R11237 R11246 R11402
COG: COG0448
Genes
CJA: CJA_3254(glgC)
SUR: STAUR_1375(gacR) STAUR_3141
SHY: SHJG_0277
SHO: SHJGH_0111
SALS: SLNWT_0584
SGU: SGLAU_01015(gacR)
SSIA: A7J05_03480
AMI: Amir_2002
APRE: CNX65_10000
ASE: ACPL_3670(acbR)
ACTS: ACWT_3542
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yang J, Xu H, Zhang Y, Bai L, Deng Z, Mahmud T
  Title
Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis.
  Journal
Org Biomol Chem 9:438-49 (2011)
DOI:10.1039/c0ob00475h
  Sequence
[ase:ACPL_3670] [sho:SHJGH_0111]

KEGG   ENZYME: 2.7.7.91Help
Entry
EC 2.7.7.91                 Enzyme                                 

Name
valienol-1-phosphate guanylyltransferase;
vldB (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
GTP:valienol 1-phosphate guanylyltransferase
Reaction(IUBMB)
GTP + valienol 1-phosphate = diphosphate + GDP-valienol [RN:R11402]
Reaction(KEGG)
R11402;
(other) R11237 R11246
Show
Substrate
GTP [CPD:C00044];
valienol 1-phosphate [CPD:C21367]
Product
diphosphate [CPD:C00013];
GDP-valienol [CPD:C21368]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 2.7.7.91 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K20427  valienol-1-phosphate guanylyltransferase
Genes
CJA: CJA_3254(glgC)
SUR: STAUR_1375(gacR) STAUR_3141
SHY: SHJG_0277
SHO: SHJGH_0111
SALS: SLNWT_0584
SGU: SGLAU_01015(gacR)
SSIA: A7J05_03480
AMI: Amir_2002
APRE: CNX65_10000
ASE: ACPL_3670(acbR)
ACTS: ACWT_3542
 » show all
Taxonomy
Reference
1  [PMID:20981366]
  Authors
Yang J, Xu H, Zhang Y, Bai L, Deng Z, Mahmud T.
  Title
Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis.
  Journal
Org Biomol Chem 9:438-49 (2011)
DOI:10.1039/c0ob00475h
  Sequence
[shy:SHJG_0277]
Reference
2  [PMID:21766819]
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T.
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.91
IUBMB Enzyme Nomenclature: 2.7.7.91
ExPASy - ENZYME nomenclature database: 2.7.7.91
BRENDA, the Enzyme Database: 2.7.7.91

KEGG   REACTION: R11246Help
Entry
R11246                      Reaction                               

Definition
1,7-Diphospho-1-epi-valienol + Nucleoside triphosphate <=> NDP-1-epi-valienol 7-phosphate + Diphosphate
Equation
Reaction class
RC00002  C21206_C21207
Enzyme
Pathway
rn00525  Acarbose and validamycin biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00814  Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
Orthology
K20427  valienol-1-phosphate guanylyltransferase [EC:2.7.7.91]

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