KEGG   ORTHOLOGY: K20433Help
Entry
K20433                      KO                                     

Name
valC
Definition
C7-cyclitol 7-kinase [EC:2.7.1.214]
Pathway
ko00525  Acarbose and validamycin biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K20433  valC; C7-cyclitol 7-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.214  C7-cyclitol 7-kinase
     K20433  valC; C7-cyclitol 7-kinase
BRITE hierarchy
Other DBs
RN: R11234
COG: COG1940
Genes
CJA: CJA_3253
SUR: STAUR_1374(gacM)
SHY: SHJG_0278
SHO: SHJGH_0112
SGU: SGLAU_01045(gacM)
TaxonomyKoalaUniProt
Reference
  Authors
Minagawa K, Zhang Y, Ito T, Bai L, Deng Z, Mahmud T
  Title
ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.
  Journal
Chembiochem 8:632-41 (2007)
DOI:10.1002/cbic.200600528
  Sequence

KEGG   ENZYME: 2.7.1.214Help
Entry
EC 2.7.1.214                Enzyme                                 

Name
C7-cyclitol 7-kinase;
valC (gene name);
vldC (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:C7-cyclitol 7-phosphotransferase
Reaction(IUBMB)
(1) ATP + valienone = ADP + valienone 7-phosphate [RN:R11234];
(2) ATP + validone = ADP + validone 7-phosphate [RN:R11406]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
valienone [CPD:C17696];
validone [CPD:C21371]
Product
ADP [CPD:C00008];
valienone 7-phosphate [CPD:C17697];
validone 7-phosphate [CPD:C21218]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus var. jinggangensis, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 2.7.1.214 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K20433  C7-cyclitol 7-kinase
Genes
CJA: CJA_3253
SUR: STAUR_1374(gacM)
SHY: SHJG_0278
SHO: SHJGH_0112
SGU: SGLAU_01045(gacM)
Taxonomy
Reference
1  [PMID:17335096]
  Authors
Minagawa K, Zhang Y, Ito T, Bai L, Deng Z, Mahmud T.
  Title
ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.
  Journal
Chembiochem 8:632-41 (2007)
DOI:10.1002/cbic.200600528
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.214
IUBMB Enzyme Nomenclature: 2.7.1.214
ExPASy - ENZYME nomenclature database: 2.7.1.214
BRENDA, the Enzyme Database: 2.7.1.214

KEGG   REACTION: R11234Help
Entry
R11234                      Reaction                               

Name
ATP:valienone 7-phosphotransferase
Definition
Valienone + ATP <=> Valienone 7-phosphate + ADP
Equation
Reaction class
RC00017  C17696_C17697
Enzyme
Pathway
rn00525  Acarbose and validamycin biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Orthology
K20433  C7-cyclitol 7-kinase [EC:2.7.1.214]
Other DBs
RHEA: 49423

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