KEGG   ORTHOLOGY: K20437Help
Entry
K20437                      KO                                     

Name
vldH
Definition
validoxylamine A 7'-phosphate phosphatase [EC:3.1.3.101]
Pathway
ko00525  Acarbose and validamycin biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K20437  vldH; validoxylamine A 7'-phosphate phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.101  validoxylamine A 7'-phosphate phosphatase
     K20437  vldH; validoxylamine A 7'-phosphate phosphatase
BRITE hierarchy
Other DBs
RN: R11240
COG: COG0637
Genes
SHY: SHJG_0271
SHO: SHJGH_0105
TaxonomyKoalaUniProt
Reference
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
  Sequence
[shy:SHJG_0271]
Reference
  Authors
Bai L, Li L, Xu H, Minagawa K, Yu Y, Zhang Y, Zhou X, Floss HG, Mahmud T, Deng Z
  Title
Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.
  Journal
Chem Biol 13:387-97 (2006)
DOI:10.1016/j.chembiol.2006.02.002
  Sequence
[shy:SHJG_0271]

KEGG   ENZYME: 3.1.3.101Help
Entry
EC 3.1.3.101                Enzyme                                 

Name
validoxylamine A 7'-phosphate phosphatase;
vldH (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
validoxylamine-A 7'-phosphate phosphohydrolase
Reaction(IUBMB)
validoxylamine A 7'-phosphate + H2O = validoxylamine A + phosphate [RN:R11240]
Reaction(KEGG)
Substrate
validoxylamine A 7'-phosphate [CPD:C21219];
H2O [CPD:C00001]
Product
validoxylamine A [CPD:C17700];
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 3.1.3.101 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K20437  validoxylamine A 7'-phosphate phosphatase
Genes
SHY: SHJG_0271
SHO: SHJGH_0105
Taxonomy
Reference
1  [PMID:21766819]
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T.
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.101
IUBMB Enzyme Nomenclature: 3.1.3.101
ExPASy - ENZYME nomenclature database: 3.1.3.101
BRENDA, the Enzyme Database: 3.1.3.101

KEGG   REACTION: R11240Help
Entry
R11240                      Reaction                               

Definition
Validoxylamine A 7'-phosphate + H2O <=> Validoxylamine A + Orthophosphate
Equation
Reaction class
RC00017  C17700_C21219
Enzyme
Pathway
rn00525  Acarbose and validamycin biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Orthology
K20437  validoxylamine A 7'-phosphate phosphatase [EC:3.1.3.101]

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