KEGG   ORTHOLOGY: K20438Help
Entry
K20438                      KO                                     

Name
valG
Definition
validoxylamine A glucosyltransferase [EC:2.4.1.338]
Pathway
ko00525  Acarbose and validamycin biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K20438  valG; validoxylamine A glucosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.338  validoxylamine A glucosyltransferase
     K20438  valG; validoxylamine A glucosyltransferase
BRITE hierarchy
Other DBs
RN: R11241
COG: COG1216
CAZy: GT2
Genes
SHY: SHJG_0282
SHO: SHJGH_0116
TaxonomyKoalaUniProt
Reference
  Authors
Xu H, Minagawa K, Bai L, Deng Z, Mahmud T
  Title
Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A.
  Journal
J Nat Prod 71:1233-6 (2008)
DOI:10.1021/np800185k
  Sequence
[shy:SHJG_0282]

KEGG   ENZYME: 2.4.1.338Help
Entry
EC 2.4.1.338                Enzyme                                 

Name
validoxylamine A glucosyltransferase;
vldK (gene name);
valG (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:validoxylamine-A 4'-O-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + validoxylamine A = UDP + validamycin A [RN:R11241]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
validoxylamine A [CPD:C17700]
Product
UDP [CPD:C00015];
validamycin A [CPD:C12112]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, catalyses the ultimate step in the biosynthesis of the antifungal agent validamycin A.
History
EC 2.4.1.338 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K20438  validoxylamine A glucosyltransferase
Genes
SHY: SHJG_0282
SHO: SHJGH_0116
Taxonomy
Reference
1  [PMID:16632251]
  Authors
Bai L, Li L, Xu H, Minagawa K, Yu Y, Zhang Y, Zhou X, Floss HG, Mahmud T, Deng Z.
  Title
Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.
  Journal
Chem Biol 13:387-97 (2006)
DOI:10.1016/j.chembiol.2006.02.002
  Sequence
[shy:SHJG_0282]
Reference
2  [PMID:18563934]
  Authors
Xu H, Minagawa K, Bai L, Deng Z, Mahmud T
  Title
Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A.
  Journal
J Nat Prod 71:1233-6 (2008)
DOI:10.1021/np800185k
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.338
IUBMB Enzyme Nomenclature: 2.4.1.338
ExPASy - ENZYME nomenclature database: 2.4.1.338
BRENDA, the Enzyme Database: 2.4.1.338

KEGG   REACTION: R11241Help
Entry
R11241                      Reaction                               

Definition
Validoxylamine A + UDP-glucose <=> Validamycin A + UDP
Equation
Reaction class
RC00049  C12112_C17700
Enzyme
Pathway
rn00525  Acarbose and validamycin biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Orthology
K20438  validoxylamine A glucosyltransferase [EC:2.4.1.338]
Other DBs
RHEA: 49391

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