KEGG   ORTHOLOGY: K20454Help
Entry
K20454                      KO                                     

Name
dml
Definition
2,3-dimethylmalate lyase [EC:4.1.3.32]
Pathway
ko00760  Nicotinate and nicotinamide metabolism
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K20454  dml; 2,3-dimethylmalate lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.32  2,3-dimethylmalate lyase
     K20454  dml; 2,3-dimethylmalate lyase
BRITE hierarchy
Other DBs
RN: R01355
COG: COG2513
GO: 0047529
Genes
GQU: AWC35_01530
OSG: BST96_03935
FHA: CDV26_05960
HCO: LOKO_02505
CCUP: BKK81_31115
CUP: BKK80_25235
CUU: BKK79_30945
CPAU: EHF44_18850
BYI: BYI23_D004370 BYI23_D016130
BUO: BRPE64_DCDS07520
BXB: DR64_5793(dml) DR64_5796
BPAR: BN117_0676(bcpA)
BBR: BB0718(bcpA)
BBH: BN112_2717(bcpA)
BBX: BBS798_0696(bcpA)
ODI: ODI_R0009
LIM: L103DPR2_00115(dml_1)
LIH: L63ED372_02665(dml_2)
DFL: DFE_2439
DTO: TOL2_C32170(prpB)
RBS: RHODOSMS8_00141(Dml)
OAH: DR92_3570
BBT: BBta_1130
MAQU: Maq22A_c11835(prpB)
RID: RIdsm_00807(dml_1) RIdsm_00986(dml_3)
SPHT: K426_02710
SHUM: STHU_07460(bcpA_1) STHU_28130(bcpA_2) STHU_44600(bcpA_3)
SVC: STVA_12400(bcpA_1) STVA_27150(bcpA_2) STVA_47280(bcpA_3)
TMO: TMO_0464 TMO_1641(bcpA) TMO_2853(bcpA)
SAY: TPY_1957(prpB)
BPRS: CK3_05980
TAE: TepiRe1_0449(Dml)
STED: SPTER_39090(dml)
AIN: Acin_0042(prpB)
PFAC: PFJ30894_01316(Dml)
MAO: MAP4_1570
MAVI: RC58_07825
MAVU: RE97_07820
MHAD: B586_11375
SCT: SCAT_p1676(bcpA)
MMAR: MODMU_4056
PDX: Psed_4635
PSEA: WY02_01050
PSEE: FRP1_09770
PAUT: Pdca_36590(bcpA)
CALH: IJ00_22045
AGV: OJF2_03440(dml)
NMR: Nmar_0256
NCT: NMSP_1456
NEV: NTE_01742
NCV: NCAV_1312
NBV: T478_1196
NDV: NDEV_1848
AG: ABC88406(dml)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
  Sequence

KEGG   ENZYME: 4.1.3.32Help
Entry
EC 4.1.3.32                 Enzyme                                 

Name
2,3-dimethylmalate lyase;
2,3-dimethylmalate pyruvate-lyase;
(2R,3S)-2,3-dimethylmalate pyruvate-lyase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)
Reaction(IUBMB)
(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate [RN:R01355]
Reaction(KEGG)
Substrate
(2R,3S)-2,3-dimethylmalate [CPD:C03652]
Product
propanoate [CPD:C00163];
pyruvate [CPD:C00022]
History
EC 4.1.3.32 created 1981
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K20454  2,3-dimethylmalate lyase
Genes
GQU: AWC35_01530
OSG: BST96_03935
FHA: CDV26_05960
HCO: LOKO_02505
CCUP: BKK81_31115
CUP: BKK80_25235
CUU: BKK79_30945
CPAU: EHF44_18850
BYI: BYI23_D004370 BYI23_D016130
BUO: BRPE64_DCDS07520
BXB: DR64_5793(dml) DR64_5796
BPAR: BN117_0676(bcpA)
BBR: BB0718(bcpA)
BBH: BN112_2717(bcpA)
BBX: BBS798_0696(bcpA)
ODI: ODI_R0009
LIM: L103DPR2_00115(dml_1)
LIH: L63ED372_02665(dml_2)
DFL: DFE_2439
DTO: TOL2_C32170(prpB)
RBS: RHODOSMS8_00141(Dml)
OAH: DR92_3570
BBT: BBta_1130
MAQU: Maq22A_c11835(prpB)
RID: RIdsm_00807(dml_1) RIdsm_00986(dml_3)
SPHT: K426_02710
SHUM: STHU_07460(bcpA_1) STHU_28130(bcpA_2) STHU_44600(bcpA_3)
SVC: STVA_12400(bcpA_1) STVA_27150(bcpA_2) STVA_47280(bcpA_3)
TMO: TMO_0464 TMO_1641(bcpA) TMO_2853(bcpA)
SAY: TPY_1957(prpB)
BPRS: CK3_05980
TAE: TepiRe1_0449(Dml)
STED: SPTER_39090(dml)
AIN: Acin_0042(prpB)
PFAC: PFJ30894_01316(Dml)
MAO: MAP4_1570
MAVI: RC58_07825
MAVU: RE97_07820
MHAD: B586_11375
SCT: SCAT_p1676(bcpA)
MMAR: MODMU_4056
PDX: Psed_4635
PSEA: WY02_01050
PSEE: FRP1_09770
PAUT: Pdca_36590(bcpA)
CALH: IJ00_22045
AGV: OJF2_03440(dml)
NMR: Nmar_0256
NCT: NMSP_1456
NEV: NTE_01742
NCV: NCAV_1312
NBV: T478_1196
NDV: NDEV_1848
 » show all
Taxonomy
Reference
1  [PMID:527937]
  Authors
Pirzer P, Lill U, Eggerer H.
  Title
Nicotinic acid metabolism. 2,3-Dimethylmalate lyase.
  Journal
Hoppe Seylers Z Physiol Chem 360:1693-702 (1979)
  Sequence
Reference
2  [PMID:16894175]
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.32
IUBMB Enzyme Nomenclature: 4.1.3.32
ExPASy - ENZYME nomenclature database: 4.1.3.32
BRENDA, the Enzyme Database: 4.1.3.32
CAS: 73562-28-4

KEGG   REACTION: R01355Help
Entry
R01355                      Reaction                               

Name
2,3-dimethylmalate pyruvate-lyase
Definition
(2R,3S)-2,3-Dimethylmalate <=> Propanoate + Pyruvate
Equation
Reaction class
RC00286  C00022_C03652
RC01810  C00163_C03652
Enzyme
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01120  Microbial metabolism in diverse environments
Orthology
K20454  2,3-dimethylmalate lyase [EC:4.1.3.32]
Other DBs
RHEA: 10475

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