KEGG   ORTHOLOGY: K20566
Entry
K20566            Tight     KO                                     
Symbol
kanI
Name
paromamine 6'-oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase [EC:1.1.3.43 1.1.3.-]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08896  paromamine:oxygen 6'-oxidoreductase
R10207  2'-deamino-2'-hydroxyparomamine:oxygen 6'-oxidoreductase
R11267  kanamycin-X:oxygen 6'-oxidoreductase
R11268  kanamycin-C:oxygen 6'-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20566  kanI; paromamine 6'-oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.43  paromamine 6'-oxidase
     K20566  kanI; paromamine 6'-oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase
Other DBs
COG: COG2303
Genes
SKA: CP970_06660
AG: CAF60534(kanI)
Reference
PMID:15313224
  Authors
Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK
  Title
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.
  Journal
Arch Biochem Biophys 429:204-14 (2004)
DOI:10.1016/j.abb.2004.06.009
  Sequence
[ag:CAF60534]
Reference
PMID:21983602
  Authors
Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
  Title
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
  Journal
Nat Chem Biol 7:843-52 (2011)
DOI:10.1038/nchembio.671

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG GENES (2)   
Literature (2)   
   PubMed (2)   
All databases (17)   

Download RDF
KEGG   ORTHOLOGY: K13552
Entry
K13552            Tight     KO                                     
Symbol
btrQ
Name
paromamine 6'-oxidase [EC:1.1.3.43]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08896  paromamine:oxygen 6'-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K13552  btrQ; paromamine 6'-oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.43  paromamine 6'-oxidase
     K13552  btrQ; paromamine 6'-oxidase
Other DBs
COG: COG2303
Genes
AG: BAE07079(btrQ)
Reference
PMID:16156513
  Authors
Kudo F, Numakura M, Tamegai H, Yamamoto H, Eguchi T, Kakinuma K
  Title
Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073.
  Journal
J Antibiot (Tokyo) 58:373-9 (2005)
DOI:10.1038/ja.2005.47
  Sequence
[ag:BAE07079]
Reference
PMID:19362652
  Authors
Kudo F, Eguchi T
  Title
Biosynthetic enzymes for the aminoglycosides butirosin and neomycin.
  Journal
Methods Enzymol 459:493-519 (2009)
DOI:10.1016/S0076-6879(09)04620-5

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (1)   
   KEGG GENES (1)   
Literature (2)   
   PubMed (2)   
All databases (13)   

Download RDF
KEGG   ORTHOLOGY: K20565
Entry
K20565                      KO                                     
Symbol
neoG, neoQ
Name
paromamine 6'-oxidase / 6'''-hydroxyneomycin C oxidase [EC:1.1.3.43 1.1.3.44]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08896  paromamine:oxygen 6'-oxidoreductase
R08902  6'''-deamino-6'''-hydroxyneomycin-C:oxygen 6'''-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20565  neoG, neoQ; paromamine 6'-oxidase / 6'''-hydroxyneomycin C oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.43  paromamine 6'-oxidase
     K20565  neoG, neoQ; paromamine 6'-oxidase / 6'''-hydroxyneomycin C oxidase
    1.1.3.44  6'''-hydroxyneomycin C oxidase
     K20565  neoG, neoQ; paromamine 6'-oxidase / 6'''-hydroxyneomycin C oxidase
Other DBs
COG: COG2303
Genes
SRN: A4G23_05124(neoG)
SFB: CP974_27345
DMAT: Dmats_04980
AG: BAD95824(neoG)
Reference
PMID:16506694
  Authors
Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K
  Title
Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.
  Journal
J Antibiot (Tokyo) 58:766-74 (2005)
DOI:10.1038/ja.2005.104
  Sequence
[ag:BAD95824]
Reference
PMID:17206729
  Authors
Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB
  Title
Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin.
  Journal
Chembiochem 8:283-8 (2007)
DOI:10.1002/cbic.200600371

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (5)   
   KEGG GENES (4)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (19)   

Download RDF
KEGG   ORTHOLOGY: K20577
Entry
K20577            Tight     KO                                     
Symbol
aprQ
Name
paromamine/lividamine 6'-oxidase [EC:1.1.3.43 1.1.3.-]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08896  paromamine:oxygen 6'-oxidoreductase
R11273  lividamine:oxygen 6'-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20577  aprQ; paromamine/lividamine 6'-oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.43  paromamine 6'-oxidase
     K20577  aprQ; paromamine/lividamine 6'-oxidase
Other DBs
COG: COG2303
Genes
AG: CAF33053(aprQ)
Reference
PMID:27120352
  Authors
Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z, Yu Y, Zhang Q
  Title
Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis.
  Journal
J Am Chem Soc 138:6427-35 (2016)
DOI:10.1021/jacs.6b02221
  Sequence
[ag:CAF33053]

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (1)   
   KEGG GENES (1)   
Literature (1)   
   PubMed (1)   
All databases (13)   

Download RDF
DBGET integrated database retrieval system