KEGG   ORTHOLOGY: K20567
Entry
K20567                      KO                                     
Symbol
neoN
Name
neamine transaminase / neomycin C transaminase [EC:2.6.1.93 2.6.1.95]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08897  neamine:2-oxoglutarate aminotransferase
R08903  2-oxoglutarate:neomycin-C aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20567  neoN; neamine transaminase / neomycin C transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.93  neamine transaminase
     K20567  neoN; neamine transaminase / neomycin C transaminase
    2.6.1.95  neomycin C transaminase
     K20567  neoN; neamine transaminase / neomycin C transaminase
Other DBs
COG: COG0001
Genes
SRN: A4G23_05117(neoN)
SFB: CP974_27310
AG: BAD95831(neoN)
Reference
PMID:16506694
  Authors
Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K
  Title
Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.
  Journal
J Antibiot (Tokyo) 58:766-74 (2005)
DOI:10.1038/ja.2005.104
  Sequence
[ag:BAD95831]
Reference
PMID:17206729
  Authors
Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB
  Title
Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin.
  Journal
Chembiochem 8:283-8 (2007)
DOI:10.1002/cbic.200600371

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Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (4)   
   KEGG GENES (3)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (19)   

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KEGG   ORTHOLOGY: K20568
Entry
K20568            Tight     KO                                     
Symbol
kacL
Name
neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase [EC:2.6.1.93 2.6.1.94]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08897  neamine:2-oxoglutarate aminotransferase
R10094  2'-deamino-2'-hydroxyneamine:2-oxoglutarate aminotransferase
R11269  kanamycin-A:2-oxoglutarate aminotransferase
R11270  kanamycin-B:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20568  kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.93  neamine transaminase
     K20568  kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase
    2.6.1.94  2'-deamino-2'-hydroxyneamine transaminase
     K20568  kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase
Other DBs
COG: COG0001
Genes
AG: CAE22475(tobB) CAF60533(kacL)
Reference
PMID:15313224
  Authors
Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK
  Title
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.
  Journal
Arch Biochem Biophys 429:204-14 (2004)
DOI:10.1016/j.abb.2004.06.009
  Sequence
[ag:CAF60533]
Reference
PMID:21983602
  Authors
Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
  Title
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
  Journal
Nat Chem Biol 7:843-52 (2011)
DOI:10.1038/nchembio.671

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (8)   
   KEGG ENZYME (2)   
   KEGG REACTION (4)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG GENES (2)   
Literature (2)   
   PubMed (2)   
All databases (19)   

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KEGG   ORTHOLOGY: K13553
Entry
K13553            Tight     KO                                     
Symbol
btrB
Name
neamine transaminase [EC:2.6.1.93]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08897  neamine:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K13553  btrB; neamine transaminase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes
    K13553  btrB; neamine transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.93  neamine transaminase
     K13553  btrB; neamine transaminase
Amino acid related enzymes [BR:ko01007]
 Aminotransferase (transaminase)
  Class III
   K13553  btrB; neamine transaminase
Genes
AG: BAE07066(btrB)
Reference
PMID:16156513
  Authors
Kudo F, Numakura M, Tamegai H, Yamamoto H, Eguchi T, Kakinuma K
  Title
Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073.
  Journal
J Antibiot (Tokyo) 58:373-9 (2005)
DOI:10.1038/ja.2005.47
  Sequence
[ag:BAE07066]
Reference
PMID:19362652
  Authors
Kudo F, Eguchi T
  Title
Biosynthetic enzymes for the aminoglycosides butirosin and neomycin.
  Journal
Methods Enzymol 459:493-519 (2009)
DOI:10.1016/S0076-6879(09)04620-5

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (1)   
   KEGG GENES (1)   
Literature (2)   
   PubMed (2)   
All databases (14)   

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