KEGG   ORTHOLOGY: K20568
Entry
K20568            Tight     KO                                     
Symbol
kacL
Name
neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase [EC:2.6.1.93 2.6.1.94]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08897  neamine:2-oxoglutarate aminotransferase
R10094  2'-deamino-2'-hydroxyneamine:2-oxoglutarate aminotransferase
R11269  kanamycin-A:2-oxoglutarate aminotransferase
R11270  kanamycin-B:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20568  kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.93  neamine transaminase
     K20568  kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase
    2.6.1.94  2'-deamino-2'-hydroxyneamine transaminase
     K20568  kacL; neamine transaminase / 2'-deamino-2'-hydroxyneamine transaminase
Other DBs
COG: COG0001
Genes
AG: CAE22475(tobB) CAF60533(kacL)
Reference
PMID:15313224
  Authors
Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK
  Title
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.
  Journal
Arch Biochem Biophys 429:204-14 (2004)
DOI:10.1016/j.abb.2004.06.009
  Sequence
[ag:CAF60533]
Reference
PMID:21983602
  Authors
Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
  Title
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
  Journal
Nat Chem Biol 7:843-52 (2011)
DOI:10.1038/nchembio.671

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (8)   
   KEGG ENZYME (2)   
   KEGG REACTION (4)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG GENES (2)   
Literature (2)   
   PubMed (2)   
All databases (19)   

Download RDF
DBGET integrated database retrieval system