KEGG   ORTHOLOGY: K20575Help
Entry
K20575                      KO                                     

Name
aprD4
Definition
radical SAM diol-dehydratase
Pathway
ko00524  Neomycin, kanamycin and gentamicin biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20575  aprD4; radical SAM diol-dehydratase
BRITE hierarchy
Other DBs
RN: R11274 R11275
COG: COG1032
Genes
AG: CAF33054(aprD4)
TaxonomyKoalaUniProt
Reference
  Authors
Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z, Yu Y, Zhang Q
  Title
Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis.
  Journal
J Am Chem Soc 138:6427-35 (2016)
DOI:10.1021/jacs.6b02221
  Sequence
Reference
  Authors
Kim HJ, LeVieux J, Yeh YC, Liu HW
  Title
C3'-Deoxygenation of Paromamine Catalyzed by a Radical S-Adenosylmethionine Enzyme: Characterization of the Enzyme AprD4 and Its Reductase Partner AprD3.
  Journal
Angew Chem Int Ed Engl 55:3724-8 (2016)
DOI:10.1002/anie.201510635

KEGG   REACTION: R11274Help
Entry
R11274                      Reaction                               

Definition
Paromamine + S-Adenosyl-L-methionine + Reduced acceptor <=> 4'-Oxolividamine + L-Methionine + 5'-Deoxyadenosine + Acceptor + H2O
Equation
Reaction class
RC03406  C01743_C21257
Pathway
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K20575  radical SAM diol-dehydratase

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