KEGG   ORTHOLOGY: K20682Help
Entry
K20682                      KO                                     

Name
ravNMT
Definition
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase [EC:2.1.1.236]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K20682  ravNMT; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.236  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
     K20682  ravNMT; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
BRITE hierarchy
Other DBs
RN: R09821
COG: COG0500
Genes
AG: CBH32796(RavNMT)
TaxonomyKoalaUniProt
Reference
  Authors
Kharel MK, Nybo SE, Shepherd MD, Rohr J
  Title
Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters.
  Journal
Chembiochem 11:523-32 (2010)
DOI:10.1002/cbic.200900673
  Sequence

KEGG   ENZYME: 2.1.1.236Help
Entry
EC 2.1.1.236                Enzyme                                 

Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase;
RavNMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose [RN:R09821]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose [CPD:C19947]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose [CPD:C19948]
Comment
The enzyme is involved in the synthesis of dTDP-D-ravidosamine, the amino sugar moiety of the antibiotic ravidomycin V, which is produced by the bacterium Streptomyces ravidus.
History
EC 2.1.1.236 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K20682  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
Reference
1  [PMID:21264378]
  Authors
Kharel MK, Lian H, Rohr J
  Title
Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate.
  Journal
Org Biomol Chem 9:1799-808 (2011)
DOI:10.1039/c0ob00854k
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.236
IUBMB Enzyme Nomenclature: 2.1.1.236
ExPASy - ENZYME nomenclature database: 2.1.1.236
BRENDA, the Enzyme Database: 2.1.1.236

KEGG   REACTION: R09821Help
Entry
R09821                      Reaction                               

Name
S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase
Definition
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-Adenosyl-L-methionine <=> dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-Adenosyl-L-homocysteine
Equation
C19947 + 2 C00019 <=> C19948 + 2 C00021
Reaction class
RC00003  C00019_C00021
RC01515  C19947_C19948
Enzyme
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K20682  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase [EC:2.1.1.236]
Other DBs
RHEA: 31618

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