KEGG   ORTHOLOGY: K20859
Entry
K20859                      KO                                     

Name
phnPP
Definition
phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase [EC:3.1.4.57]
Pathway
ko00440  Phosphonate and phosphinate metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K20859  phnPP; phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.57  phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
     K20859  phnPP; phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
Other DBs
RN: R10972 R10973
COG: COG0613
Genes
PMR: PMI2225
PMIB: BB2000_2358
PVL: AOB99_13045
ORB: IPMB12_08225
BON: A361_16710
BKO: CKF48_11535
OIH: OB0975
OCN: CUC15_18900
OCB: CV093_20380
LGY: T479_13155
BTS: Btus_3094
EMU: EMQU_2192
CBA: CLB_0694
CBH: CLC_0709
CBY: CLM_0769
CBL: CLK_0057
CBB: CLD_0101
CBI: CLJ_B0727
CBF: CLI_0732
CBM: CBF_0700
ESR: ES1_20910
ESU: EUS_09310
CCEL: CCDG5_0088
RCH: RUM_21690
FPR: FP2_18910
PDC: CDIF630_03845(phnPP)
APR: Apre_0404
ELE: Elen_0235
AEQ: AEQU_1669
 » show all
Reference
  Authors
Ghodge SV, Cummings JA, Williams HJ, Raushel FM
  Title
Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis of both ester bonds to phosphorus.
  Journal
J Am Chem Soc 135:16360-3 (2013)
DOI:10.1021/ja409376k
  Sequence
[ele:Elen_0235]

KEGG   ENZYME: 3.1.4.57
Entry
EC 3.1.4.57                 Enzyme                                 

Name
phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase;
cyclic phosphate dihydrolase;
phnPP (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1,2-diphosphophosphohydrolase
Reaction(IUBMB)
(1) 5-phospho-alpha-D-ribose 1,2-cyclic phosphate + H2O = D-ribofuranose 2,5-bisphosphate [RN:R10972];
(2) D-ribofuranose 2,5-bisphosphate + H2O = D-ribofuranose 5-phosphate + phosphate [RN:R10973]
Reaction(KEGG)
R10972 R10973
Substrate
5-phospho-alpha-D-ribose 1,2-cyclic phosphate [CPD:C20440];
H2O [CPD:C00001];
D-ribofuranose 2,5-bisphosphate
Product
D-ribofuranose 2,5-bisphosphate;
D-ribofuranose 5-phosphate;
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Eggerthella lenta, is involed in degradation of methylphosphonate.
History
EC 3.1.4.57 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K20859  phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
Genes
PMR: PMI2225
PMIB: BB2000_2358
PVL: AOB99_13045
ORB: IPMB12_08225
BON: A361_16710
BKO: CKF48_11535
OIH: OB0975
OCN: CUC15_18900
OCB: CV093_20380
LGY: T479_13155
BTS: Btus_3094
EMU: EMQU_2192
CBA: CLB_0694
CBH: CLC_0709
CBY: CLM_0769
CBL: CLK_0057
CBB: CLD_0101
CBI: CLJ_B0727
CBF: CLI_0732
CBM: CBF_0700
ESR: ES1_20910
ESU: EUS_09310
CCEL: CCDG5_0088
RCH: RUM_21690
FPR: FP2_18910
PDC: CDIF630_03845(phnPP)
APR: Apre_0404
ELE: Elen_0235
AEQ: AEQU_1669
 » show all
Reference
1  [PMID:24147537]
  Authors
Ghodge SV, Cummings JA, Williams HJ, Raushel FM
  Title
Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis  of both ester bonds to phosphorus.
  Journal
J Am Chem Soc 135:16360-3 (2013)
DOI:10.1021/ja409376k
  Sequence
[ele:Elen_0235]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.57
IUBMB Enzyme Nomenclature: 3.1.4.57
ExPASy - ENZYME nomenclature database: 3.1.4.57
BRENDA, the Enzyme Database: 3.1.4.57

KEGG   REACTION: R10973
Entry
R10973                      Reaction                               

Name
D-ribose-2,5-bisphosphate 2-phosphohydrolase
Definition
D-Ribose 2,5-bisphosphate + H2O <=> D-Ribose 5-phosphate + Orthophosphate
Equation
Reaction class
RC00078  C00117_C20986
Enzyme
Pathway
rn00440  Phosphonate and phosphinate metabolism
Orthology
K20859  phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase [EC:3.1.4.57]

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