KEGG   ORTHOLOGY: K20932
Entry
K20932                      KO                                     

Name
K20932
Definition
hydrazine synthase subunit [EC:1.7.2.7]
Pathway
ko00910  Nitrogen metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    K20932  K20932; hydrazine synthase subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.2  With a cytochrome as acceptor
    1.7.2.7  hydrazine synthase
     K20932  K20932; hydrazine synthase subunit
Other DBs
RN: R09799
COG: COG3391
Genes
KST: KSMBR1_2703(hzsC_3)
AG: CAJ73611
Reference
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence

KEGG   ORTHOLOGY: K20933
Entry
K20933                      KO                                     

Name
K20933
Definition
hydrazine synthase subunit [EC:1.7.2.7]
Pathway
ko00910  Nitrogen metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    K20933  K20933; hydrazine synthase subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.2  With a cytochrome as acceptor
    1.7.2.7  hydrazine synthase
     K20933  K20933; hydrazine synthase subunit
Other DBs
RN: R09799
COG: COG1858
Genes
KST: KSMBR1_2704(hzsB_3)
AG: CAJ73612
Reference
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence

KEGG   ORTHOLOGY: K20934
Entry
K20934                      KO                                     

Name
K20934
Definition
hydrazine synthase subunit [EC:1.7.2.7]
Pathway
ko00910  Nitrogen metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    K20934  K20934; hydrazine synthase subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.2  With a cytochrome as acceptor
    1.7.2.7  hydrazine synthase
     K20934  K20934; hydrazine synthase subunit
Other DBs
RN: R09799
COG: COG0823
Genes
KST: KSMBR1_2713(hzsA_1)
AG: CAJ73613
Reference
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence

KEGG   ENZYME: 1.7.2.7
Entry
EC 1.7.2.7                  Enzyme                                 

Name
hydrazine synthase;
HZS
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
Sysname
hydrazine:ferricytochrome-c oxidoreductase
Reaction(IUBMB)
hydrazine + H2O + 3 ferricytochrome c = nitric oxide + ammonium + 3 ferrocytochrome c [RN:R09799]
Reaction(KEGG)
R09799
Substrate
hydrazine [CPD:C05361];
H2O [CPD:C00001];
ferricytochrome c [CPD:C00125]
Product
nitric oxide [CPD:C00533];
ammonium;
ferrocytochrome c [CPD:C00126]
Comment
The enzyme, characterized from anaerobic ammonia oxidizers (anammox bacteria), is one of only two enzymes that are known to form an N-N bond (the other being EC 1.7.1.14, nitric oxide reductase [NAD(P)+, nitrous oxide-forming]). The enzyme from the bacterium Candidatus Kuenenia stuttgartiensis is heterotrimeric and contains multiple c-type cytochromes.
History
EC 1.7.2.7 created 2016
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K20932  hydrazine synthase subunit
K20933  hydrazine synthase subunit
K20934  hydrazine synthase subunit
Genes
KST: KSMBR1_2703(hzsC_3) KSMBR1_2704(hzsB_3) KSMBR1_2713(hzsA_1)
Reference
1  [PMID:21964329]
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M.
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.7
IUBMB Enzyme Nomenclature: 1.7.2.7
ExPASy - ENZYME nomenclature database: 1.7.2.7
BRENDA, the Enzyme Database: 1.7.2.7

KEGG   REACTION: R09799
Entry
R09799                      Reaction                               

Name
hydrazine:ferricytochrome-c oxidoreductase
Definition
Nitric oxide + Ammonia + 3 Ferrocytochrome c <=> Hydrazine + H2O + 3 Ferricytochrome c
Equation
Enzyme
Pathway
rn00910  Nitrogen metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K20932  hydrazine synthase subunit [EC:1.7.2.7]
K20933  hydrazine synthase subunit [EC:1.7.2.7]
K20934  hydrazine synthase subunit [EC:1.7.2.7]
Other DBs
RHEA: 49819

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