KEGG   ORTHOLOGY: K20935
Entry
K20935                      KO                                     

Name
hdh
Definition
hydrazine dehydrogenase [EC:1.7.2.8]
Pathway
ko00910  Nitrogen metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    K20935  hdh; hydrazine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.2  With a cytochrome as acceptor
    1.7.2.8  hydrazine dehydrogenase
     K20935  hdh; hydrazine dehydrogenase
Other DBs
RN: R07174
Genes
KST: KSMBR1_2369(hdh)
AG: CAJ71439
Reference
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence

KEGG   ENZYME: 1.7.2.8
Entry
EC 1.7.2.8                  Enzyme                                 

Name
hydrazine dehydrogenase;
HDH
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
Sysname
hydrazine:ferricytochrome c oxidoreductase
Reaction(IUBMB)
hydrazine + 4 ferricytochrome c = N2 + 4 ferrocytochrome c [RN:R07174]
Reaction(KEGG)
R07174
Substrate
hydrazine [CPD:C05361];
ferricytochrome c [CPD:C00125]
Product
N2 [CPD:C00697];
ferrocytochrome c [CPD:C00126]
Comment
The enzyme, which is involved in the pathway of anaerobic ammonium oxidation in anammox bacteria, has been purified from the bacterium Candidatus Kuenenia stuttgartiensis. The electrons derived from hydrazine are eventually transferred to the quinone pool.
History
EC 1.7.2.8 created 2003 as EC 1.7.99.8, modified 2010, transferred 2016 to EC 1.7.2.8
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K20935  hydrazine dehydrogenase
Genes
KST: KSMBR1_2369(hdh)
Reference
1  [PMID:10820012]
  Authors
Schalk J, de Vries S, Kuenen JG, Jetten MS.
  Title
Involvement of a novel hydroxylamine oxidoreductase in anaerobic ammonium oxidation.
  Journal
Biochemistry 39:5405-12 (2000)
DOI:10.1021/bi992721k
Reference
2  [PMID:11404106]
  Authors
Jetten MS, Wagner M, Fuerst J, van Loosdrecht M, Kuenen G, Strous M.
  Title
Microbiology and application of the anaerobic ammonium oxidation ('anammox') process.
  Journal
Curr Opin Biotechnol 12:283-8 (2001)
DOI:10.1016/S0958-1669(00)00211-1
Reference
3  [PMID:21964329]
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M.
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence
Reference
4  [PMID:23210799]
  Authors
Kartal B, de Almeida NM, Maalcke WJ, Op den Camp HJ, Jetten MS, Keltjens JT
  Title
How to make a living from anaerobic ammonium oxidation.
  Journal
FEMS Microbiol Rev 37:428-61 (2013)
DOI:10.1111/1574-6976.12014
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.8
IUBMB Enzyme Nomenclature: 1.7.2.8
ExPASy - ENZYME nomenclature database: 1.7.2.8
BRENDA, the Enzyme Database: 1.7.2.8
CAS: 9075-43-8

KEGG   REACTION: R07174
Entry
R07174                      Reaction                               

Name
hydrazine:ferricytochrome c oxidoreductase
Definition
Hydrazine + 4 Ferricytochrome c <=> Nitrogen + 4 Ferrocytochrome c
Equation
C05361 + 4 C00125 <=> C00697 + 4 C00126
Reaction class
RC02951  C00697_C05361
Enzyme
Pathway
rn00910  Nitrogen metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K20935  hydrazine dehydrogenase [EC:1.7.2.8]
Other DBs
RHEA: 23235

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