KEGG   ORTHOLOGY: K21182Help
Entry
K21182                      KO                                     

Name
sgcC1, mdpC1
Definition
(S)-beta-tyrosine adenylation enzyme [EC:6.2.1.-]
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00828  Maduropeptin beta-hydroxy acid moiety biosynthesis, tyrosine => 3-(4-hydroxyphenyl)-3-oxopropanoyl-PCP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21182  sgcC1, mdpC1; (S)-beta-tyrosine adenylation enzyme
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.-  
     K21182  sgcC1, mdpC1; (S)-beta-tyrosine adenylation enzyme
BRITE hierarchy
Other DBs
RN: R11367
COG: COG1020
Genes
SGB: WQO_33890
AJA: AJAP_16295
SAQ: Sare_2093
VMA: VAB18032_18470
AG: ABY66004(mdpC1)
TaxonomyKoalaUniProt
Reference
PMID:12183628 (sgcC1)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33890]
Reference
PMID:17918933 (mdpC1)
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
Reference
  Authors
Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B
  Title
Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
J Biol Chem 281:29633-40 (2006)
DOI:10.1074/jbc.M605887200

KEGG   REACTION: R11367Help
Entry
R11367                      Reaction                               

Name
(S)-beta-tyrosine:[peptidyl-carrier protein] ligase (AMP-forming)
Definition
ATP + (S)-beta-Tyrosine + Peptidyl-carrier protein <=> AMP + Diphosphate + (S)-beta-Tyrosyl-[pcp]
Equation
Reaction class
RC00014  C21308_C21309
RC00039  C21097_C21309
Enzyme
6.2.1.-
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00828  Maduropeptin beta-hydroxy acid moiety biosynthesis, tyrosine => 3-(4-hydroxyphenyl)-3-oxopropanoyl-PCP
Orthology
K21182  (S)-beta-tyrosine adenylation enzyme [EC:6.2.1.-]

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