KEGG   ORTHOLOGY: K21183
Entry
K21183                      KO                                     
Symbol
sgcC2, mdpC2, kedY2
Name
peptidyl carrier protein
Module
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00828  Maduropeptin beta-hydroxy acid moiety biosynthesis, tyrosine => 3-(4-hydroxyphenyl)-3-oxopropanoyl-PCP
M00832  Kedarcidin 2-aza-3-chloro-beta-tyrosine moiety biosynthesis, azatyrosine => 2-aza-3-chloro-beta-tyrosyl-PCP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21183  sgcC2, mdpC2, kedY2; peptidyl carrier protein
Genes
SGB: WQO_33880
SQZ: FQU76_30285
SSPO: DDQ41_30950
SSPB: CP982_00890
NEC: KGD82_07485
AJA: AJAP_16290
ACTI: UA75_18120
ACAD: UA74_17595
ACTU: Actkin_05241(dhbF_5)
SAQ: Sare_2094
MPRN: Q3V37_18035 Q3V37_18375
PFLA: Pflav_004670
PSUU: Psuf_070440
AG: ABY66003(mdpC2) AFV52209(kedY2)
 » show all
Reference
PMID:12183628 (sgcC2)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33880]
Reference
PMID:17918933 (mdpC2)
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
[ag:ABY66003]
Reference
PMID:23633564 (kedY2)
  Authors
Huang SX, Lohman JR, Huang T, Shen B
  Title
A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway.
  Journal
Proc Natl Acad Sci U S A 110:8069-74 (2013)
DOI:10.1073/pnas.1304733110
  Sequence
[ag:AFV52209]
Reference
PMID:16887797
  Authors
Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B
  Title
Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
J Biol Chem 281:29633-40 (2006)
DOI:10.1074/jbc.M605887200

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (3)   
   KEGG MODULE (3)   
Gene (17)   
   KEGG GENES (16)   
   OC (1)   
Literature (4)   
   PubMed (4)   
All databases (25)   

Download RDF
DBGET integrated database retrieval system