KEGG   ORTHOLOGY: K21191Help
Entry
K21191                      KO                                     

Name
mdpB2
Definition
CoA ligase [EC:6.2.1.-]
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00829  3,6-Dimethylsalicylyl-CoA biosynthesis, malonyl-CoA => 6-methylsalicylate => 3,6-dimethylsalicylyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21191  mdpB2; CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.-  
     K21191  mdpB2; CoA ligase
BRITE hierarchy
Other DBs
RN: R11370
COG: COG1021
Genes
ACTI: UA75_18045
ACAD: UA74_17520
VMA: VAB18032_24835
AG: ABY66018(mdpB2)
TaxonomyKoalaUniProt
Reference
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
Reference
  Authors
Ling J, Horsman GP, Huang SX, Luo Y, Lin S, Shen B
  Title
Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.
  Journal
J Am Chem Soc 132:12534-6 (2010)
DOI:10.1021/ja1050814

KEGG   REACTION: R11370Help
Entry
R11370                      Reaction                               

Name
6-methylsalicylate:CoA ligase (AMP-forming)
Definition
ATP + 6-Methylsalicylate + CoA <=> AMP + Diphosphate + 6-Methylsalicylyl-CoA
Equation
Reaction class
RC00004  C00010_C21312
RC00174  C02657_C21312
Enzyme
6.2.1.-
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00829  3,6-Dimethylsalicylyl-CoA biosynthesis, malonyl-CoA => 6-methylsalicylate => 3,6-dimethylsalicylyl-CoA
Orthology
K21191  CoA ligase [EC:6.2.1.-]

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