KEGG   ORTHOLOGY: K21192Help
Entry
K21192                      KO                                     

Name
mdpB1
Definition
methyltransferase [EC:2.1.1.-]
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00829  3,6-Dimethylsalicylyl-CoA biosynthesis, malonyl-CoA => 6-methylsalicylate => 3,6-dimethylsalicylyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21192  mdpB1; methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-  
     K21192  mdpB1; methyltransferase
BRITE hierarchy
Other DBs
RN: R11371
Genes
ACTI: UA75_18035
ACAD: UA74_17510
VMA: VAB18032_24825
AG: ABY66020(mdpB1)
TaxonomyKoalaUniProt
Reference
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
Reference
  Authors
Ling J, Horsman GP, Huang SX, Luo Y, Lin S, Shen B
  Title
Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.
  Journal
J Am Chem Soc 132:12534-6 (2010)
DOI:10.1021/ja1050814

KEGG   REACTION: R11371Help
Entry
R11371                      Reaction                               

Name
S-adenosyl-L-methionine:6-methylsalicylyl-CoA 3-C-methyltransferase
Definition
S-Adenosyl-L-methionine + 6-Methylsalicylyl-CoA <=> S-Adenosyl-L-homocysteine + 3,6-Dimethylsalicylyl-CoA
Equation
Reaction class
RC00003  C00019_C00021
RC00332  C21312_C21313
Enzyme
2.1.1.-
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00829  3,6-Dimethylsalicylyl-CoA biosynthesis, malonyl-CoA => 6-methylsalicylate => 3,6-dimethylsalicylyl-CoA
Orthology
K21192  methyltransferase [EC:2.1.1.-]

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