| Entry |
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| Symbol |
thiDN
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| Name |
hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC: 2.7.1.49 2.7.4.7 2.5.1.3]
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| Pathway |
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| Module |
| M00127 | Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP |
| M00896 | Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP |
| M00899 | Thiamine salvage pathway, HMP/HET => TMP |
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| Reaction |
| R03223 | 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase |
| R03471 | ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase |
| R04509 | ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase |
| R10712 | 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00730 Thiamine metabolism
K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
Enzymes [BR:ko01000]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.3 thiamine phosphate synthase
K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.49 hydroxymethylpyrimidine kinase
K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
2.7.4 Phosphotransferases with a phosphate group as acceptor
2.7.4.7 phosphooxymethylpyrimidine kinase
K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
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| Other DBs |
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| Genes |
» show all
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| Reference |
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| Authors |
Morett E, Korbel JO, Rajan E, Saab-Rincon G, Olvera L, Olvera M, Schmidt S, Snel B, Bork P |
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| Title |
Systematic discovery of analogous enzymes in thiamin biosynthesis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hayashi M, Kobayashi K, Esaki H, Konno H, Akaji K, Tazuya K, Yamada K, Nakabayashi T, Nosaka K |
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| Title |
Enzymatic and structural characterization of an archaeal thiamin phosphate synthase. |
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| Journal |
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| Sequence |
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