Entry
Symbol
thiDN
Name
hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:
2.7.1.49 2.7.4.7 2.5.1.3 ]
Pathway
Module
M00127 Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP
M00896 Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
M00899 Thiamine salvage pathway, HMP/HET => TMP
Reaction
R03223 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase
R03471 ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase
R04509 ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase
R10712 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00730 Thiamine metabolism
K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
Enzymes [BR:ko01000 ]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.3 thiamine phosphate synthase
K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.49 hydroxymethylpyrimidine kinase
K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
2.7.4 Phosphotransferases with a phosphate group as acceptor
2.7.4.7 phosphooxymethylpyrimidine kinase
K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
BRITE hierarchy
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Taxonomy UniProt
Reference
Authors
Morett E, Korbel JO, Rajan E, Saab-Rincon G, Olvera L, Olvera M, Schmidt S, Snel B, Bork P
Title
Systematic discovery of analogous enzymes in thiamin biosynthesis.
Journal
Sequence
Reference
Authors
Hayashi M, Kobayashi K, Esaki H, Konno H, Akaji K, Tazuya K, Yamada K, Nakabayashi T, Nosaka K
Title
Enzymatic and structural characterization of an archaeal thiamin phosphate synthase.
Journal
Sequence