KEGG   ORTHOLOGY: K21222
Entry
K21222            Tight     KO                                     

Name
kedN3
Definition
cytochrome P450 monooxygenase [EC:1.14.-.-]
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00831  Kedarcidin 2-hydroxynaphthoate moiety biosynthesis, malonyl-CoA => 3,6,8-trihydroxy-2-naphthoate => 3-hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21222  kedN3; cytochrome P450 monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.-  Acting on paired donors, with incorporation or reduction of molecular oxygen
    1.14.-.-  
     K21222  kedN3; cytochrome P450 monooxygenase
Other DBs
RN: R11387
COG: COG2124
Genes
AG: AFV52151(kedN3)
Reference
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence

KEGG   REACTION: R11387
Entry
R11387                      Reaction                               

Definition
3,6,8-Trihydroxy-2-naphthoate + Reduced acceptor + Oxygen <=> 3,6,7,8-Tetrahydroxy-2-naphthoate + Acceptor + H2O
Equation
Comment
cytochrome P450 monooxygenase
proposed pathway
Reaction class
RC00236  C21320_C21321
Enzyme
1.14.-.-
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00831  Kedarcidin 2-hydroxynaphthoate moiety biosynthesis, malonyl-CoA => 3,6,8-trihydroxy-2-naphthoate => 3-hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA
Orthology
K21222  cytochrome P450 monooxygenase [EC:1.14.-.-]

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