KEGG   ORTHOLOGY: K21225
Entry
K21225            Tight     KO                                     

Name
kedN2
Definition
acyl-CoA synthetase
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00831  Kedarcidin 2-hydroxynaphthoate moiety biosynthesis, malonyl-CoA => 3,6,8-trihydroxy-2-naphthoate => 3-hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21225  kedN2; acyl-CoA synthetase
Other DBs
RN: R11390
COG: COG1021
Genes
AG: AFV52187(kedN2)
Reference
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence

KEGG   REACTION: R11390
Entry
R11390                      Reaction                               

Definition
3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoate + CoA <=> 3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA
Equation
Comment
proposed pathway
incomplete reaction
Reaction class
RC00004  C00010_C21324
RC00174  C21323_C21324
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00831  Kedarcidin 2-hydroxynaphthoate moiety biosynthesis, malonyl-CoA => 3,6,8-trihydroxy-2-naphthoate => 3-hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA
Orthology
K21225  acyl-CoA synthetase

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