KEGG   ORTHOLOGY: K21256Help
Entry
K21256                      KO                                     

Name
calO3
Definition
flavin-dependent halogenase
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00833  Calicheamicin biosynthesis, calicheamicinone => calicheamicin
M00834  Calicheamicin orsellinate moiety biosynthesis, malonyl-CoA => orsellinate-ACP => 5-iodo-2,3-dimethoxyorsellinate-ACP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21256  calO3; flavin-dependent halogenase
BRITE hierarchy
Other DBs
RN: R11414
COG: COG0644
Genes
SAQ: Sare_2031
AG: AAM70353(calO3)
TaxonomyKoalaUniProt
Reference
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
Reference
  Authors
McCoy JG, Johnson HD, Singh S, Bingman CA, Lei IK, Thorson JS, Phillips GN Jr
  Title
Structural characterization of CalO2: a putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway.
  Journal
Proteins 74:50-60 (2009)
DOI:10.1002/prot.22131

KEGG   REACTION: R11414Help
Entry
R11414                      Reaction                               

Definition
2-Methoxyorsellinate-[acp] + Iodide <=> 5-Iodo-2-methoxyorsellinate-[acp]
Equation
Comment
incomplete reaction
Reaction class
RC01363  C21344_C21345
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00833  Calicheamicin biosynthesis, calicheamicinone => calicheamicin
M00834  Calicheamicin orsellinate moiety biosynthesis, malonyl-CoA => orsellinate-ACP => 5-iodo-2,3-dimethoxyorsellinate-ACP
Orthology
K21256  flavin-dependent halogenase

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