KEGG   ORTHOLOGY: K21260Help
Entry
K21260                      KO                                     

Name
calG2
Definition
calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase [EC:2.4.1.-]
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00833  Calicheamicin biosynthesis, calicheamicinone => calicheamicin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21260  calG2; calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-  
     K21260  calG2; calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase
BRITE hierarchy
Other DBs
RN: R11418
COG: COG1819
CAZy: GT1
Genes
SAQ: Sare_2036
AG: AAM70348(calG2)
TaxonomyKoalaUniProt
Reference
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
Reference
  Authors
Zhang C, Bitto E, Goff RD, Singh S, Bingman CA, Griffith BR, Albermann C, Phillips GN Jr, Thorson JS
  Title
Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis.
  Journal
Chem Biol 15:842-53 (2008)
DOI:10.1016/j.chembiol.2008.06.011

KEGG   REACTION: R11418Help
Entry
R11418                      Reaction                               

Name
dTDP-4-deoxy-4-thio-alpha-D-digitoxose:calicheamicin-T0 4-deoxy-4-thio-alpha-D-digitoxosyltransferase
Definition
dTDP-4-deoxy-4-thio-alpha-D-digitoxose + Calicheamicin T0 <=> dTDP + 4-Deoxy-4-thio-alpha-D-digitoxosyl-calicheamicin T0
Equation
Reaction class
RC00005  C00363_C21349
RC03434  C21338_C21339
Enzyme
2.4.1.-
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00833  Calicheamicin biosynthesis, calicheamicinone => calicheamicin
Orthology
K21260  calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase [EC:2.4.1.-]

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