KEGG   ORTHOLOGY: K21289Help
Entry
K21289                      KO                                     

Name
PIK3CG
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04022  cGMP-PKG signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04371  Apelin signaling pathway
ko04611  Platelet activation
ko04725  Cholinergic synapse
ko04921  Oxytocin signaling pathway
ko05145  Toxoplasmosis
ko05167  Kaposi sarcoma-associated herpesvirus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04072 Phospholipase D signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04022 cGMP-PKG signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04151 PI3K-Akt signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04062 Chemokine signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  09156 Nervous system
   04725 Cholinergic synapse
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
BRITE hierarchy
Other DBs
RN: R04545
GO: 0046934
Genes
HSA: 5294(PIK3CG)
PTR: 463649(PIK3CG)
PPS: 100988420(PIK3CG)
GGO: 101153738(PIK3CG)
PON: 100453085(PIK3CG)
NLE: 100586512(PIK3CG)
MCC: 698857(PIK3CG)
MCF: 102146644(PIK3CG)
CSAB: 103226710(PIK3CG)
RRO: 104677402(PIK3CG)
RBB: 108540484(PIK3CG)
CJC: 100394268(PIK3CG)
SBQ: 101028650(PIK3CG)
MMU: 30955(Pik3cg)
MCAL: 110306848(Pik3cg)
MPAH: 110324300(Pik3cg)
RNO: 298947(Pik3cg)
MUN: 110565083(Pik3cg)
CGE: 100765862(Pik3cg)
NGI: 103732179(Pik3cg)
HGL: 101707055(Pik3cg)
CCAN: 109687395(Pik3cg)
OCU: 100344144(PIK3CG)
TUP: 102472442(PIK3CG)
CFA: 483266(PIK3CG)
VVP: 112908560(PIK3CG)
AML: 100470322(PIK3CG)
UMR: 103674633(PIK3CG)
UAH: 113258627(PIK3CG)
ORO: 101362272(PIK3CG)
ELK: 111155215
FCA: 101096215(PIK3CG)
PTG: 102953306(PIK3CG)
PPAD: 109268077(PIK3CG)
AJU: 106987833(PIK3CG)
BTA: 530001(PIK3CG)
BOM: 102277419(PIK3CG)
BIU: 109557383(PIK3CG)
BBUB: 102413532(PIK3CG)
CHX: 102173256(PIK3CG)
OAS: 101102896(PIK3CG)
SSC: 396979(PIK3CG)
CFR: 102503674(PIK3CG)
CDK: 105093031(PIK3CG)
BACU: 103004888(PIK3CG)
LVE: 103069455(PIK3CG)
OOR: 101281782(PIK3CG)
DLE: 111164603(PIK3CG)
PCAD: 102983371(PIK3CG)
ECB: 100050532(PIK3CG)
EPZ: 103557800(PIK3CG)
EAI: 106825232(PIK3CG)
MYB: 102241723(PIK3CG)
MYD: 102773870(PIK3CG)
MNA: 107530834(PIK3CG)
HAI: 109375969(PIK3CG)
DRO: 112303039(PIK3CG)
PALE: 102884972(PIK3CG)
RAY: 107511488(PIK3CG)
MJV: 108409197(PIK3CG)
LAV: 100673566(PIK3CG)
TMU: 101354532
MDO: 100009879(PIK3CG)
SHR: 100925455(PIK3CG)
PCW: 110207004(PIK3CG)
OAA: 100078046(PIK3CG)
GGA: 417706(PIK3CG)
MGP: 104914241
CJO: 107306688(PIK3CG)
NMEL: 110392374(PIK3CG)
APLA: 101796856(PIK3CG)
ACYG: 106042023(PIK3CG)
TGU: 100229232(PIK3CG)
LSR: 110472720(PIK3CG)
SCAN: 103813517(PIK3CG)
GFR: 102044692(PIK3CG)
FAB: 101811117(PIK3CG)
PHI: 102102611(PIK3CG)
PMAJ: 107204901(PIK3CG)
CCAE: 111922996(PIK3CG)
CCW: 104686866(PIK3CG)
ETL: 114060540(PIK3CG)
FPG: 101910831(PIK3CG)
FCH: 102051392(PIK3CG)
CLV: 102090627(PIK3CG)
EGZ: 104123774(PIK3CG)
NNI: 104010725(PIK3CG)
ACUN: 113490925(PIK3CG)
PADL: 103920571(PIK3CG)
AAM: 106487739(PIK3CG)
ASN: 102381149(PIK3CG)
AMJ: 102559272(PIK3CG)
PSS: 102460136(PIK3CG)
CMY: 102945282(PIK3CG)
CPIC: 101948128(PIK3CG)
ACS: 100561444(pik3cg)
PVT: 110089784(PIK3CG)
PBI: 103057875(PIK3CG)
PMUR: 107297786(PIK3CG)
TSR: 106544873 106551530(PIK3CG)
PMUA: 114605819(PIK3CG)
GJA: 107108982(PIK3CG)
XLA: 108711184 108713077(pik3cg.S)
XTR: 100158519(pik3cg)
NPR: 108797066(PIK3CG)
DRE: 406598(pik3cg) 564261(si:rp71-17i16.5)
CCAR: 109060929(pik3cg) 109076687
IPU: 108276435 108279798(pik3cg)
PHYP: 113530762 113531896(pik3cg)
AMEX: 103035431 103041836(pik3cg)
EEE: 113570029 113575802(pik3cg)
TRU: 101071229(pik3cg) 101075343
LCO: 104931247 104933235(pik3cg)
MZE: 101471620 101474181(pik3cg)
ONL: 100697462(pik3cg) 100706781
OLA: 101159013 101173828(pik3cg)
XMA: 102225994 102229099(pik3cg)
XCO: 114148414 114161029(pik3cg)
PRET: 103459664(pik3cg) 103466897
CVG: 107087086(pik3cg) 107103487
NFU: 107382729(pik3cg) 107391427
KMR: 108233022 108249075(pik3cg)
ALIM: 106523004 106524588(pik3cg)
AOCE: 111570585 111578550(pik3cg)
CSEM: 103383124(pik3cg) 103384699
LCF: 108884757 108888339(pik3cg)
SDU: 111224935(pik3cg) 111234739
SLAL: 111657680(pik3cg) 111661891
HCQ: 109513761 109528849(pik3cg)
BPEC: 110161421 110161763(pik3cg)
MALB: 109961003(pik3cg) 109970413
ELS: 105025656(pik3cg) 105027772
SFM: 108918751(pik3cg) 108925594
PKI: 111851191 111857863(pik3cg)
LCM: 102353565(PIK3CG) 102362971
CMK: 103175665 103176691(pik3cg)
CIN: 100180112
SPAR: SPRG_03711
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7624799
  Authors
Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesebroeck B, Dhand R, Nurnberg B, et al.
  Title
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.
  Journal
Science 269:690-3 (1995)
DOI:10.1126/science.7624799
  Sequence
[hsa:5294]

KEGG   ORTHOLOGY: K21290Help
Entry
K21290                      KO                                     

Name
PIK3R5_6
Definition
phosphoinositide-3-kinase regulatory subunit 5/6
Pathway
ko04022  cGMP-PKG signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04371  Apelin signaling pathway
ko04611  Platelet activation
ko04725  Cholinergic synapse
ko04921  Oxytocin signaling pathway
ko05145  Toxoplasmosis
ko05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00848  Ataxia with ocular apraxia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
   04072 Phospholipase D signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
   04022 cGMP-PKG signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
   04151 PI3K-Akt signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
   04062 Chemokine signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
  09156 Nervous system
   04725 Cholinergic synapse
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
BRITE hierarchy
Genes
HSA: 146850(PIK3R6) 23533(PIK3R5)
PTR: 455085(PIK3R5) 746196(PIK3R6)
PPS: 100981656(PIK3R6) 100981987(PIK3R5)
GGO: 101128094(PIK3R6) 101128463(PIK3R5)
PON: 100455593(PIK3R5) 100455956(PIK3R6)
NLE: 100586095(PIK3R6) 100593257(PIK3R5)
MCC: 722023(PIK3R6) 722027(PIK3R5)
MCF: 102133347(PIK3R6) 102135867(PIK3R5)
CSAB: 103242366(PIK3R6) 103242368(PIK3R5)
RRO: 104658283(PIK3R5) 104658296(PIK3R6)
RBB: 108513498(PIK3R5) 108513507(PIK3R6)
CJC: 100400385(PIK3R5) 100402223(PIK3R6) 108591734
SBQ: 101031169(PIK3R5) 101033790(PIK3R6)
MMU: 104709(Pik3r6) 320207(Pik3r5)
MCAL: 110304507(Pik3r6) 110305901(Pik3r5)
MPAH: 110331970(Pik3r5) 110332042(Pik3r6)
RNO: 497931(Pik3r5) 497932(Pik3r6)
MUN: 110551705(Pik3r5) 110551706(Pik3r6)
CGE: 100751224(Pik3r5) 100751518(Pik3r6)
NGI: 103752079(Pik3r5) 103752080(Pik3r6)
HGL: 101721410(Pik3r6) 101721762(Pik3r5)
CCAN: 109697132(Pik3r6) 109700829(Pik3r5)
OCU: 100337757(PIK3R5) 100340526(PIK3R6)
TUP: 102470324(PIK3R5) 102485065(PIK3R6) 102495389
CFA: 608225(PIK3R6) 612805(PIK3R5)
VVP: 112924887(PIK3R6) 112924888(PIK3R5)
AML: 100477067(PIK3R5) 100477324(PIK3R6)
UMR: 103660496(PIK3R6) 103660497(PIK3R5)
UAH: 113271195(PIK3R6) 113271196(PIK3R5)
ORO: 101374579(PIK3R5) 101375062(PIK3R6)
FCA: 101082104(PIK3R6) 101082354(PIK3R5)
PTG: 102954383(PIK3R5) 102954665(PIK3R6)
PPAD: 109245881(PIK3R5) 109246080(PIK3R6)
AJU: 106972459(PIK3R6) 106972460(PIK3R5)
BTA: 515621(PIK3R6) 614838(PIK3R5)
BOM: 102279608(PIK3R6) 102282596(PIK3R5)
BIU: 109573250(PIK3R5) 109574415(PIK3R6)
BBUB: 102397321(PIK3R5) 102399362(PIK3R6)
CHX: 102172481(PIK3R6) 102172758(PIK3R5)
OAS: 101109720(PIK3R6) 101109983(PIK3R5)
SSC: 100034246(PIK3R6) 396851(PIK3R5)
CFR: 102506518(PIK3R6) 102506780(PIK3R5)
CDK: 105098995(PIK3R5) 105098997(PIK3R6)
BACU: 103014949(PIK3R5) 103015229(PIK3R6)
LVE: 103076642(PIK3R6) 103076917(PIK3R5)
OOR: 101275667(PIK3R5) 101275916(PIK3R6)
DLE: 111186004(PIK3R5) 111186025(PIK3R6)
PCAD: 102976409(PIK3R6) 102979209(PIK3R5)
ECB: 100062779(PIK3R6) 100062810(PIK3R5)
EPZ: 103564501(PIK3R5) 103564503(PIK3R6)
EAI: 106845727(PIK3R6) 106845751(PIK3R5)
MYB: 102246179(PIK3R6) 102246489(PIK3R5)
MYD: 102755643(PIK3R6) 102755921(PIK3R5)
MNA: 107544506(PIK3R6) 107544531(PIK3R5)
HAI: 109395140(PIK3R6) 109395146(PIK3R5)
DRO: 112308643(PIK3R5) 112308895(PIK3R6)
PALE: 102878019(PIK3R6) 102878262(PIK3R5)
RAY: 107515658(PIK3R5) 107515659(PIK3R6)
MJV: 108387546(PIK3R6) 108392468(PIK3R5)
LAV: 100670067(PIK3R5) 100674744(PIK3R6)
MDO: 100012464(PIK3R5)
SHR: 100931238(PIK3R5)
PCW: 110194373(PIK3R5)
OAA: 100084050(PIK3R5) 103169312(PIK3R6)
GGA: 417319(PIK3R5) 769202(PIK3R6)
MGP: 100546841(PIK3R6) 100547150(PIK3R5)
CJO: 107322275(PIK3R5) 107322277(PIK3R6)
NMEL: 110407249(PIK3R5) 110407250(PIK3R6)
APLA: 101790494(PIK3R6) 101791074(PIK3R5)
ACYG: 106046698(PIK3R5) 106046720(PIK3R6)
LSR: 110475146(PIK3R6) 110475153(PIK3R5)
SCAN: 103820021(PIK3R5) 103820022(PIK3R6)
GFR: 102042317(PIK3R5) 102042485(PIK3R6)
FAB: 101814689(PIK3R6) 101818925(PIK3R5)
PHI: 102100026(PIK3R5) 102100202(PIK3R6)
PMAJ: 107212546(PIK3R5) 107212547(PIK3R6)
CCAE: 111937183(PIK3R6) 111937185(PIK3R5)
CCW: 104695667(PIK3R6) 104695668(PIK3R5)
ETL: 114064103(PIK3R6) 114064104(PIK3R5)
FPG: 101916082(PIK3R6) 101916251(PIK3R5)
FCH: 102058572(PIK3R6) 102058745(PIK3R5)
CLV: 102084322(PIK3R6) 102085068(PIK3R5)
EGZ: 104133795(PIK3R6) 104133802(PIK3R5)
NNI: 104011006(PIK3R5) 104011017(PIK3R6)
ACUN: 113486876(PIK3R6) 113486892(PIK3R5)
PADL: 103925339(PIK3R6) 103925359(PIK3R5)
AAM: 106493184(PIK3R5) 106493186(PIK3R6)
ASN: 102375158(PIK3R5) 102376480(PIK3R6)
AMJ: 102559047(PIK3R5) 102566809(PIK3R6)
PSS: 102452954(PIK3R5) 102453204(PIK3R6)
CMY: 102931130(PIK3R6) 102931359(PIK3R5)
CPIC: 101945514(PIK3R6) 101945796(PIK3R5)
ACS: 100553495(pik3r6) 100553697(pik3r5)
PVT: 110080421(PIK3R5) 110080433(PIK3R6)
PBI: 103065452(PIK3R6) 103065866(PIK3R5)
PMUR: 107286775(PIK3R6) 107286790(PIK3R5)
TSR: 106540654(PIK3R6) 106551195(PIK3R5)
PMUA: 114590746(PIK3R5) 114590747(PIK3R6)
GJA: 107123847(PIK3R5) 107123852(PIK3R6)
XLA: 108701182(pik3r5.L) 108701183(pik3r6.L) 432272(pik3r5.S)
XTR: 733968(pik3r5) 780316(pik3r6)
NPR: 108796779(PIK3R6) 108796783(PIK3R5)
DRE: 100007492 101886666(pik3r6b) 323588(pik3r5)
PHYP: 113524565(pik3r5) 113525114 113528008(pik3r6)
EEE: 113573215 113584794(pik3r5) 113584796(pik3r6)
TRU: 101073983(pik3r6) 101074203(pik3r5) 115253365
MZE: 101463967 101466926 101482173(pik3r6) 101482467(pik3r5)
ONL: 100690007 100696454(pik3r5) 102076215(pik3r6) 102078679
OLA: 101154923(pik3r6) 101155167(pik3r5) 101155772
XMA: 102225840 102232431(pik3r6) 102232697(pik3r5)
XCO: 114144896(pik3r6) 114145294(pik3r5) 114159701
PRET: 103467832(pik3r6) 103467846(pik3r5) 103468393
CVG: 107094634(pik3r5) 107099145 107099146(pik3r6)
NFU: 107376244 107382340(pik3r5) 107382343(pik3r6)
KMR: 108236216 108242695(pik3r6) 108242700(pik3r5)
ALIM: 106515181(pik3r6) 106515277(pik3r5) 106517875 106536898
AOCE: 111564223(pik3r5) 111564238(pik3r6) 111568188
CSEM: 103383581(pik3r6) 103383582(pik3r5) 103393693
SDU: 111236286(pik3r6) 111236324(pik3r5) 111238053
SLAL: 111659744(pik3r5) 111659789(pik3r6) 111673751 111673823
HCQ: 109508474 109508900 109511358(pik3r5) 109511359(pik3r6)
BPEC: 110172006 110172569 110172577(pik3r5) 110172636(pik3r6)
ELS: 105012280(pik3r5) 105012281(pik3r6) 105013165
PKI: 111833532(pik3r5) 111833591(pik3r6) 111856319
LCM: 102349632 102352897 102361229(PIK3R6) 102361486(PIK3R5)
CMK: 103175427(pik3r6) 103175428(pik3r5)
RTP: 109925223 109930167(pik3r5) 109930168(pik3r6)
CIN: 100183938
AQU: 109582644
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9094719
  Authors
Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, Coadwell J, Smrcka AS, Thelen M, Cadwallader K, Tempst P, Hawkins PT
  Title
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101.
  Journal
Cell 89:105-14 (1997)
DOI:10.1016/S0092-8674(00)80187-7
  Sequence
[ssc:396851]
Reference
  Authors
Voigt P, Dorner MB, Schaefer M
  Title
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.
  Journal
J Biol Chem 281:9977-86 (2006)
DOI:10.1074/jbc.M512502200
  Sequence
[mmu:104709]

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