KEGG   ORTHOLOGY: K21331Help
Entry
K21331                      KO                                     

Name
calS8, atmS8
Definition
dTDP-alpha-D-glucose dehydrogenase [EC:1.1.1.-]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K21331  calS8, atmS8; dTDP-alpha-D-glucose dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K21331  calS8, atmS8; dTDP-alpha-D-glucose dehydrogenase
BRITE hierarchy
Other DBs
RN: R11471
COG: COG0677
Genes
MYE: AB431_22430
NDA: Ndas_4714
NAL: B005_1437
ACTI: UA75_17995
ACAD: UA74_17470
SAQ: Sare_2117 Sare_2174
VMA: VAB18032_24815
AG: AAM70332(calS8) ABC02801(atmS8) ABY66024(mdpA2)
TaxonomyKoalaUniProt
Reference
  Authors
Singh S, Michalska K, Bigelow L, Endres M, Kharel MK, Babnigg G, Yennamalli RM, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr
  Title
Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.
  Journal
J Biol Chem 290:26249-58 (2015)
DOI:10.1074/jbc.M115.673459
Reference
PMID:26289554 (atmS8)
  Authors
Peltier-Pain P, Singh S, Thorson JS
  Title
Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.
  Journal
Chembiochem 16:2141-6 (2015)
DOI:10.1002/cbic.201500365
  Sequence
Reference
PMID:12183629 (calS8)
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence

KEGG   REACTION: R11471Help
Entry
R11471                      Reaction                               

Name
dTDP-glucose:NAD+ 6-oxidoreductase
Definition
dTDP-glucose + 2 NAD+ + H2O <=> dTDP-D-glucuronate + 2 NADH + 2 H+
Equation
C00842 + 2 C00003 + C00001 <=> C06017 + 2 C00004 + 2 C00080
Reaction class
RC00291  C00842_C06017
Enzyme
1.1.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K21331  dTDP-alpha-D-glucose dehydrogenase [EC:1.1.1.-]

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