KEGG   ORTHOLOGY: K21332Help
Entry
K21332                      KO                                     

Name
calS9, atmS9
Definition
dTDP-alpha-D-glucuronic acid decarboxylase [EC:1.1.1.-]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K21332  calS9, atmS9; dTDP-alpha-D-glucuronic acid decarboxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K21332  calS9, atmS9; dTDP-alpha-D-glucuronic acid decarboxylase
BRITE hierarchy
Other DBs
RN: R11472
COG: COG0451
Genes
MYE: AB431_22425
NDA: Ndas_4713
NAL: B005_1438
ACTI: UA75_18075
ACAD: UA74_17550
SAQ: Sare_2116 Sare_2173
VMA: VAB18032_24810
AG: AAM70333(calS9) ABC02802(atmS9) ABY66025(mdpA3)
TaxonomyKoalaUniProt
Reference
PMID:26289554 (atmS9)
  Authors
Peltier-Pain P, Singh S, Thorson JS
  Title
Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.
  Journal
Chembiochem 16:2141-6 (2015)
DOI:10.1002/cbic.201500365
  Sequence
Reference
PMID:12183629 (calS9)
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence

KEGG   REACTION: R11472Help
Entry
R11472                      Reaction                               

Name
dTDP-D-glucuronate:NAD+ oxidoreductase (decarboxylating)
Definition
dTDP-D-glucuronate + NAD+ <=> dTDP-4-oxo-alpha-D-xylose + CO2 + NADH + H+
Equation
Reaction class
RC01812  C06017_C21351
Enzyme
1.1.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K21332  dTDP-alpha-D-glucuronic acid decarboxylase [EC:1.1.1.-]

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