KEGG   ORTHOLOGY: K21338Help
Entry
K21338                      KO                                     

Name
ppzP
Definition
5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase [EC:2.5.1.121]
Pathway
ko00405  Phenazine biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00405 Phenazine biosynthesis
    K21338  ppzP; 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.121  5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
     K21338  ppzP; 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
BRITE hierarchy
Other DBs
RN: R10966
Genes
AG: CAX48655(ppzP)
TaxonomyKoalaUniProt
Reference
  Authors
Saleh O, Gust B, Boll B, Fiedler HP, Heide L
  Title
Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus.
  Journal
J Biol Chem 284:14439-47 (2009)
DOI:10.1074/jbc.M901312200
  Sequence

KEGG   ENZYME: 2.5.1.121Help
Entry
EC 2.5.1.121                Enzyme                                 

Name
5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase;
PpzP;
dihydrophenazine-1-carboxylate dimethylallyltransferase;
5,10-dihydrophenazine 1-carboxylate dimethylallyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl diphosphate:5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
Reaction(IUBMB)
dimethylallyl diphosphate + 5,10-dihydrophenazine-1-carboxylate = diphosphate + 9-(dimethylallyl)-5,10-dihydrophenazine-1-carboxylate [RN:R10966]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
5,10-dihydrophenazine-1-carboxylate [CPD:C20981]
Product
diphosphate [CPD:C00013];
9-(dimethylallyl)-5,10-dihydrophenazine-1-carboxylate [CPD:C20982]
Comment
The enzyme is involved in the biosynthesis of prenylated phenazines by the bacterium Streptomyces anulatus. It is specific for both dimethylallyl diphosphate and 5,10-dihydrophenazine-1-carboxylate.
History
EC 2.5.1.121 created 2014
Pathway
ec00405  Phenazine biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K21338  5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
Reference
1  [PMID:19339241]
  Authors
Saleh O, Gust B, Boll B, Fiedler HP, Heide L
  Title
Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus.
  Journal
J Biol Chem 284:14439-47 (2009)
DOI:10.1074/jbc.M901312200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.121
IUBMB Enzyme Nomenclature: 2.5.1.121
ExPASy - ENZYME nomenclature database: 2.5.1.121
BRENDA, the Enzyme Database: 2.5.1.121

KEGG   REACTION: R10966Help
Entry
R10966                      Reaction                               

Name
dimethylallyl-diphosphate:5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
Definition
Dimethylallyl diphosphate + 5,10-Dihydrophenazine-1-carboxylate <=> Diphosphate + 9-(Dimethylallyl)-5,10-dihydrophenazine-1-carboxylate
Equation
Reaction class
RC00209  C20981_C20982
Enzyme
Pathway
rn00405  Phenazine biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K21338  5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase [EC:2.5.1.121]

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