KEGG ORTHOLOGY: K21357

ORTHOLOGY: K21357

Entry

K21357                      KO

Symbol

ULK1

Name

serine/threonine-protein kinase ULK1 [EC:2.7.11.1]

Pathway

map04137

Mitophagy - animal

map04140

Autophagy - animal

map04150

mTOR signaling pathway

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map05010

Alzheimer disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05017

Spinocerebellar ataxia

map05022

Pathways of neurodegeneration - multiple diseases

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K21357  ULK1; serine/threonine-protein kinase ULK1
   04150 mTOR signaling pathway
    K21357  ULK1; serine/threonine-protein kinase ULK1
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K21357  ULK1; serine/threonine-protein kinase ULK1
   04137 Mitophagy - animal
    K21357  ULK1; serine/threonine-protein kinase ULK1
09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    K21357  ULK1; serine/threonine-protein kinase ULK1
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K21357  ULK1; serine/threonine-protein kinase ULK1
   05014 Amyotrophic lateral sclerosis
    K21357  ULK1; serine/threonine-protein kinase ULK1
   05016 Huntington disease
    K21357  ULK1; serine/threonine-protein kinase ULK1
   05017 Spinocerebellar ataxia
    K21357  ULK1; serine/threonine-protein kinase ULK1
   05022 Pathways of neurodegeneration - multiple diseases
    K21357  ULK1; serine/threonine-protein kinase ULK1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K21357  ULK1; serine/threonine-protein kinase ULK1
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K21357  ULK1; serine/threonine-protein kinase ULK1
   03029 Mitochondrial biogenesis
    K21357  ULK1; serine/threonine-protein kinase ULK1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K21357  ULK1; serine/threonine-protein kinase ULK1
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  ULK family [OT]
   K21357  ULK1; serine/threonine-protein kinase ULK1
Membrane trafficking [BR:ko04131]
Autophagy
  Autophagosome formation proteins
   ULK complex
    K21357  ULK1; serine/threonine-protein kinase ULK1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    K21357  ULK1; serine/threonine-protein kinase ULK1

Genes

HSA:	8408(ULK1)

PTR:	744289(ULK1)

PPS:	100970765(ULK1)

GGO:	101149691(ULK1)

PON:	100450395(ULK1)

PPYG:

129010510(ULK1)

NLE:	100583005(ULK1)

HMH:	116477673(ULK1)

SSYN:

129459707(ULK1)

MCC:	709746(ULK1)

MCF:	102141167(ULK1)

MTHB:

126930540

MNI:	105490544(ULK1)

CSAB:

103239428(ULK1)

CATY:

105591065(ULK1)

PANU:

101010161(ULK1)

TGE:	112634975(ULK1)

MLEU:

105541289(ULK1)

RRO:	104674321(ULK1)

RBB:	108527503(ULK1)

TFN:	117089166(ULK1)

PTEH:

111529825(ULK1)

CANG:

105525659(ULK1)

CJC:	100403342(ULK1)

SBQ:	101030459(ULK1)

CIMI:

108292658(ULK1)

ANAN:

105705163(ULK1)

CSYR:

103265752(ULK1)

MMUR:

105879455(ULK1)

LCAT:

123625959(ULK1)

PCOQ:

105820727(ULK1)

OGA:	100956503(ULK1)

MMU:	22241(Ulk1)

MCAL:

110294005(Ulk1)

MPAH:

110339107(Ulk1)

RNO:	360827(Ulk1)

MCOC:

116068139(Ulk1)

ANU:	117697702(Ulk1)

MUN:	110553155(Ulk1)

CGE:	100772932(Ulk1)

MAUA:

101822707(Ulk1)

PROB:

127215928(Ulk1)

PLEU:

114682897(Ulk1)

MORG:

121446066(Ulk1)

MFOT:

126488524

AAMP:

119824755(Ulk1)

NGI:	103750609(Ulk1)

HGL:	101714353(Ulk1)

CPOC:

100719170(Ulk1)

CCAN:

109697545(Ulk1)

DORD:

105990593(Ulk1)

DSP:	122102030(Ulk1)

PLOP:

125349234(Ulk1)

NCAR:

124990355

MMMA:

107159067(Ulk1)

OCU:

100350803

OPI:	101521994(ULK1)

TUP:	102477255(ULK1)

GVR:	103592037(ULK1)

CFA:	477437(ULK1)

CLUD:

112676397(ULK1)

VVP:	112911606(ULK1)

VLG:	121475361(ULK1)

NPO:	129507807(ULK1)

AML:	100470276(ULK1)

UMR:	103678902(ULK1)

UAH:	113266853(ULK1)

UAR:	123803317(ULK1)

ELK:

111140006

LLV:

125081694

MPUF:

101670633(ULK1)

MNP:	132023055(ULK1)

MLK:	131811225(ULK1)

NVS:	122903104(ULK1)

ORO:	101366573(ULK1)

EJU:	114202566(ULK1)

ZCA:	113913119(ULK1)

MLX:	118018362(ULK1)

NSU:	110587139(ULK1)

LWW:	102727750(ULK1)

FCA:	101098658(ULK1)

PYU:	121022734(ULK1)

PBG:	122470101(ULK1)

PVIV:

125149227(ULK1)

LRUF:

124527799

PTG:	102952269(ULK1)

PPAD:

109260065(ULK1)

PUC:

125915056

AJU:

106979514

HHV:	120223258(ULK1)

BTA:	526310(ULK1)

BOM:	102277562(ULK1)

BIU:	109571223(ULK1)

BBUB:

102398206(ULK1)

BBIS:

104997628(ULK1)

CHX:	102173325(ULK1)

OAS:	101117701(ULK1)

BTAX:

128062633(ULK1)

ODA:	120871548(ULK1)

CCAD:

122454327(ULK1)

MBEZ:

129542526(ULK1)

SSC:	100151990(ULK1)

CFR:	102508563(ULK1)

CBAI:

105063754(ULK1)

CDK:	105094622(ULK1)

VPC:	102537655(ULK1)

BACU:

103000929(ULK1)

BMUS:

118906757(ULK1)

LVE:	103075192(ULK1)

OOR:	101281996(ULK1)

DLE:	111186827(ULK1)

PCAD:

102990173(ULK1)

PSIU:

116765194(ULK1)

NASI:

112396223(ULK1)

EPZ:	103553436(ULK1)

EAI:	106843858(ULK1)

MYB:	102240341(ULK1)

MYD:	102767979(ULK1)

MMYO:

118653012(ULK1)

MDT:	132222052(ULK1)

PKL:	118716850(ULK1)

EFUS:

103300408(ULK1)

MNA:	107529676(ULK1)

DRO:	112310681(ULK1)

SHON:

118990988(ULK1)

AJM:	119060692(ULK1)

PDIC:

114489729(ULK1)

PHAS:

123822781(ULK1)

MMF:	118639772(ULK1)

PPAM:

129087425(ULK1)

HAI:	109396788(ULK1)

RFQ:	117017538(ULK1)

PALE:

102893241(ULK1)

PGIG:

120615974(ULK1)

PVP:	105299561(ULK1)

RAY:	107511543(ULK1)

MJV:	108399379(ULK1)

TOD:	119245083(ULK1)

SARA:

101550164(ULK1)

SETR:

126001085(ULK1)

LAV:	100677118(ULK1)

TMU:

101357581

ETF:	101648588(ULK1)

DNM:	101423988(ULK1)

MDO:	100028481(ULK1)

GAS:	123244556(ULK1)

SHR:	100934149(ULK1)

AFZ:

127545363

PCW:	110220320(ULK1)

TVP:	118835764(ULK1)

OAA:	100093196(ULK1)

GGA:	416800(ULK1)

PCOC:

116228682(ULK1)

MGP:	100548157(ULK1)

CJO:	107321083(ULK1)

TPAI:

128084607(ULK1)

LMUT:

125701929(ULK1)

NMEL:

110406441(ULK1)

APLA:

101797231(ULK1)

ACYG:

106031210(ULK1)

CATA:

118252859(ULK1)

AFUL:

116496026(ULK1)

TGU:	100226619(ULK1)

LSR:	110478078(ULK1)

SCAN:

103818101(ULK1)

PMOA:

120509700(ULK1)

OTC:	121339005(ULK1)

PRUF:

121365157(ULK1)

GFR:	102038562(ULK1)

FAB:	101809001(ULK1)

OMA:	130259750(ULK1)

PHI:	102112005(ULK1)

PMAJ:

107211711(ULK1)

CCAE:

111936486(ULK1)

CCW:	104688633(ULK1)

CBRC:

103616091(ULK1)

ETL:	114066581(ULK1)

ZAB:	102073647(ULK1)

ZLE:	135454495(ULK1)

ACHL:

103800320(ULK1)

SVG:	106852388(ULK1)

MMEA:

130579632(ULK1)

HRT:	120760394(ULK1)

SATI:

136368958(ULK1)

FPG:	101920864(ULK1)

FCH:	102059652(ULK1)

CCRI:

104161271(ULK1)

NNT:	104407650(ULK1)

SHAB:

115614172(ULK1)

ACUN:

113486041(ULK1)

TALA:

104368331(ULK1)

ACHC:

115345420(ULK1)

HALD:

104324662(ULK1)

HLE:	104840636(ULK1)

AGEN:

126040327

GCL:

127022710

CSTI:

104552923(ULK1)

LDI:	104352548(ULK1)

MNB:	103781619(ULK1)

DPUB:

104309668(ULK1)

AVIT:

104272537(ULK1)

BRHI:

104496769(ULK1)

EGZ:	104127189(ULK1)

NNI:	104019896(ULK1)

PCRI:

104033551(ULK1)

PCAO:

104049812(ULK1)

PADL:

103912402(ULK1)

AFOR:

103894863(ULK1)

FGA:	104074545(ULK1)

GSTE:

104255088(ULK1)

CLV:	102092693(ULK1)

MUI:	104538658(ULK1)

PGUU:

104467444

PLET:

104620690(ULK1)

EHS:	104516957(ULK1)

CMAC:

104477342(ULK1)

CUCA:

104054670(ULK1)

TEO:	104373071(ULK1)

BREG:

104640452(ULK1)

OHA:	104327591(ULK1)

ACAR:

104531174(ULK1)

CPEA:

104388726(ULK1)

CVF:	104289221(ULK1)

RTD:	128916859(ULK1)

AAM:	106497614(ULK1)

AROW:

112962579(ULK1)

NPD:	112945930(ULK1)

TGT:	104580554(ULK1)

DNE:	112980452(ULK1)

SCAM:

104138909(ULK1)

ASN:	102372779(ULK1)

AMJ:	102565589(ULK1)

CPOO:

109312997(ULK1)

GGN:	109290482(ULK1)

PSS:	102443852(ULK1)

CMY:	102945384(ULK1)

CCAY:

125622732(ULK1)

DCC:	119843579(ULK1)

CPIC:

101949936(ULK1)

TST:	117887991(ULK1)

CABI:

116839801(ULK1)

MRV:	120386156(ULK1)

ACS:	100561587(ulk1)

ASAO:

132781402(ULK1)

PVT:	110076575(ULK1)

SUND:

121916467(ULK1)

PBI:	103056702(ULK1)

PMUR:

107299178(ULK1)

CTIG:

120303125(ULK1)

PGUT:

117676404(ULK1)

APRI:

131185580(ULK1)

PTEX:

113446550(ULK1)

NSS:	113427344(ULK1)

VKO:	123028694(ULK1)

PMUA:

114586111(ULK1)

PRAF:

128403431(ULK1)

ZVI:	118076584(ULK1)

HCG:	128338173(ULK1)

GJA:	107108284(ULK1)

STOW:

125442671(ULK1)

EMC:	129341189(ULK1)

XLA:	108707144(ulk1.S) 108716267(ulk1.L)

XTR:	100127200(ulk1)

NPR:	108788565(ULK1)

RTEM:

120935602(ULK1)

BBUF:

120988658(ULK1)

BGAR:

122924489(ULK1)

MUO:	115479510(ULK1)

GSH:	117366021(ULK1)

DRE:	100170793(ulk1a) 558848(ulk1b)

SRX:	107726210 107736885 107739710 107753128

SANH:

107659619 107661377 107684495 107692289

SGH:	107548792 107553829 107566016 107595678

CCAR:

109046278 109057379

CAUA:

113038784 113064109 113071417 113074410 113107483

CGIB:

127941749 127963855 127985865 128018477

PTET:

122326452(ulk1b) 122350267(ulk1a)

LROH:

127152380(ulk1b) 127170199(ulk1a)

OMC:	131528997(ulk1b) 131546023(ulk1a)

PPRM:

120485819(ulk1a) 120490747(ulk1b)

RKG:	130078688(ulk1b) 130102039(ulk1a)

MAMB:

125252187(ulk1b) 125279567(ulk1a)

CIDE:

127503840 127517526

CERY:

137012583(ulk1b) 137027191(ulk1a)

MASI:

127414762 127424131 127428822 127430581

TROS:

130568645(ulk1a) 130570139(ulk1b)

TDW:	130407215(ulk1a) 130407634(ulk1b)

MANU:

129414151(ulk1a) 129423649(ulk1b)

IPU:	108265551(ulk1a) 108279004(ulk1b)

IFU:	128607389(ulk1a) 128622170(ulk1b)

PHYP:

113535536(ulk1) 113546005

SMEO:

124397721(ulk1b) 124400383(ulk1a)

TFD:	113653827(ulk1a) 113661753(ulk1b)

TVC:	132853620(ulk1a) 132859525(ulk1b)

TRN:	134318448(ulk1a) 134330111(ulk1b)

AMEX:

103021360(ulk1a) 103042154(ulk1b)

CMAO:

118813117(ulk1a) 118820416(ulk1b)

EEE:	113573444(ulk1) 113584871

CHAR:

105890021(ulk1a) 105909516(ulk1b)

TRU:	101076837 105419003(ulk1)

TFS:	130519779(ulk1b) 130526091(ulk1a)

TNG:	GSTEN00011656G001

LCO:	104920108 104933467

NCC:	104943547 104961519(ulk1)

TBEN:

117473230(ulk1a) 117476512(ulk1b)

CGOB:

115013008 115016437(ulk1)

PGEO:

117452820(ulk1a) 117456031(ulk1b)

GACU:

117543999(ulk1a) 117554771(ulk1b)

EMAC:

134868522(ulk1b) 134873254(ulk1a)

ELY:	117253150(ulk1a) 117269688(ulk1b)

EFO:	125890438(ulk1a) 125905912(ulk1b)

PLEP:

121944808(ulk1a) 121959518(ulk1b)

SLUC:

116048912(ulk1b) 116050561(ulk1a)

ECRA:

117945041(ulk1a) 117958939(ulk1b)

ESP:	116690379 116703896(ulk1)

PFLV:

114556418 114571073(ulk1)

GAT:	120831167(ulk1a) 120831614(ulk1b)

PPUG:

119225472(ulk1a) 119226588(ulk1b)

AFB:	129100919(ulk1a) 129102204(ulk1b)

CLUM:

117736800(ulk1a) 117740237(ulk1b)

PSWI:

130196368(ulk1a) 130205147(ulk1b)

MSAM:

119892018(ulk1a) 119914369(ulk1b)

SCHU:

122866114(ulk1b) 122875907(ulk1a)

CUD:	121510262(ulk1a) 121524984(ulk1b)

ALAT:

119019164(ulk1a) 119029738(ulk1b)

MZE:	101471730 101472768

ONL:	100699294 100702529(ulk1)

OAU:	116323303(ulk1a) 116335172(ulk1b)

OLA:	101155703(ulk1) 101167046

OML:	112148270(ulk1a) 112163150(ulk1b)

CSAI:

133451572 133455355(ulk1b)

XMA:	102220165(ulk1) 102238002

XCO:	114149469(ulk1) 114155070

XHE:	116724205(ulk1) 116730315

PRET:

103469663 103473584(ulk1)

PFOR:

103147404(ulk1) 103148389

PLAI:

106935279(ulk1) 106941702

PMEI:

106918299(ulk1) 106932070

GAF:	122828103(ulk1a) 122847137(ulk1b)

PPRL:

129366635(ulk1b) 129372919(ulk1a)

CVG:	107081776(ulk1) 107090965

CTUL:

119776623(ulk1b) 119790670(ulk1a)

GMU:	124872559(ulk1b) 124878606(ulk1a)

NFU:	107374177 107397066(ulk1)

KMR:	108232687(ulk1b) 108247312(ulk1a)

ALIM:

106513539(ulk1) 106528300

NWH:	119413644 119424889(ulk1b)

AOCE:

111578833(ulk1) 111581899 111583080

MCEP:

124996632(ulk1b) 125011644(ulk1a)

CSEM:

103389416(ulk1)

POV:	109626411(ulk1) 109633574

SSEN:

122758278(ulk1b) 122770117(ulk1a)

HHIP:

117768171(ulk1a) 117771635(ulk1b)

HSP:	118115029(ulk1a) 118125606(ulk1b)

PPLT:

128424667(ulk1b) 128438833(ulk1a)

SMAU:

118285594(ulk1b) 118313979(ulk1a)

LCF:	108878714(ulk1a) 108879275(ulk1b)

SDU:	111231860 111233068(ulk1)

SLAL:

111645045 111655639

XGL:	120805825(ulk1a) 120806215(ulk1b)

HCQ:	109511601 109515115(ulk1)

SSCV:

125980188 125993715

SBIA:

133490848(ulk1b) 133499080(ulk1a)

PEE:	133399657(ulk1a) 133413379(ulk1b)

PTAO:

133475642(ulk1a) 133490070(ulk1b)

BPEC:

110166347 110169891

MALB:

109954765 109965629

BSPL:

114862946(ulk1a) 114866734(ulk1b)

SJO:	128364485(ulk1a) 128380210(ulk1b)

SASA:

106563157 106566325(ulk1) 106579916

STRU:

115159639 115200038 115204015

OTW:	112220375(ulk1b) 112230934 112262995(ulk1a)

OMY:	110509735 110523524(ulk1b) 110535949(ulk1a)

OGO:	124006762 124036235 124049022

ONE:	115121939 115125727 115139963

OKI:	109868083 109873787 109895827

OKE:	118358266(ulk1a) 118385507 118387480

SALP:

111957844 111961680(ulk1) 111964508

SNH:	120021252 120025438 120063189

CCLU:

121541619 121550251 121582574

ELS:	105014825(ulk1) 105024833

SFM:	108921936(ulk1)

PKI:	111856566(ulk1)

AANG:

118206203(ulk1a) 118212902(ulk1b)

LOC:	102688482(ulk1)

PSPA:

121297148 121307708

ARUT:

117426103 117427648

PSEX:

120540891

LCM:	102351366(ULK1)

CMK:	103188023(ulk1b)

CPLA:

122562503

HOC:	132827015(ulk1b)

BBEL:

DPOL:

MAEA:

LAK:

OVI:	T265_00379

EGL:

EGR_03447

PSQ:	PUNSTDRAFT_134854

FME:	FOMMEDRAFT_144283

CCI:	CC1G_03607

ABP:	AGABI1DRAFT62752(AGABI1DRAFT_62752)

ABV:	AGABI2DRAFT120057(AGABI2DRAFT_120057)

PTM:	GSPATT00006775001

» show all

Reference

PMID:9693035

Authors

Kuroyanagi H, Yan J, Seki N, Yamanouchi Y, Suzuki Y, Takano T, Muramatsu M, Shirasawa T

Title

Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment.

Journal

Genomics 51:76-85 (1998)
DOI:10.1006/geno.1998.5340

Sequence

[hsa:8408]

Reference

PMID:21205641

Authors

Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ

Title

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

Journal

Science 331:456-61 (2011)
DOI:10.1126/science.1196371

Sequence

[hsa:8408]

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1345)   
   KEGG GENES (543)   
   KEGG MGENES (428)   
   RefGene (366)   
   OC (8)   
Literature (2)   
   PubMed (2)   
All databases (1373)   

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