KEGG ORTHOLOGY: K21421

ORTHOLOGY: K21421

Entry

K21421                      KO

Symbol

NOX2, GP91, CYBB

Name

NADPH oxidase 2 [EC:1.-.-.-]

Pathway

map04066

HIF-1 signaling pathway

map04145

Phagosome

map04216

Ferroptosis

map04217

Necroptosis

map04613

Neutrophil extracellular trap formation

map04621

NOD-like receptor signaling pathway

map04670

Leukocyte transendothelial migration

map04933

AGE-RAGE signaling pathway in diabetic complications

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05140

Leishmaniasis

map05171

Coronavirus disease - COVID-19

map05415

Diabetic cardiomyopathy

map05417

Lipid and atherosclerosis

Disease

H00089

IFN-gamma/IL-12 axis

H00098

Chronic granulomatous disease

H01167

Granulibacter infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09143 Cell growth and death
   04216 Ferroptosis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   04217 Necroptosis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   04621 NOD-like receptor signaling pathway
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   04670 Leukocyte transendothelial migration
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   05020 Prion disease
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   05022 Pathways of neurodegeneration - multiple diseases
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   05415 Diabetic cardiomyopathy
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
Membrane trafficking [BR:ko04131]
Others
  NADPH oxidases (Nox) and associated proteins
   NADPH oxidases
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2

Other DBs

GO:

0016175

TC:

5.B.1.1.1

Genes

HSA:	1536(CYBB)

PTR:	465566(CYBB)

PPS:

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	696542(CYBB)

MCF:

102122418

MTHB:

126946357

MNI:

105463247

CSAB:

103247465(CYBB)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100415466(CYBB)

SBQ:

CIMI:

ANAN:

CSYR:

MMUR:

PCOQ:

OGA:

MMU:	13058(Cybb)

MCAL:

110286646

MPAH:

110313555

RNO:	66021(Cybb)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100008801(CYBB)

OPI:

101520179

TUP:

102468293

GVR:

103593579

CFA:	491825(CYBB)

CLUD:

VVP:

VLG:

NPO:

AML:	100468223 109490984

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101086207(CYBB)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	281112(CYBB)

BOM:

BBUB:

BBIS:

CHX:

OAS:	100036757(CYBB)

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	397108(GP91-PHOX)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100050132(CYBB)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:

GGA:	418581(CYBB)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106042157(CYBB)

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136358145(CYBB)

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CSTI:

LDI:

MNB:

DPUB:

AVIT:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

GSTE:

CLV:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	444353(cybb.L)

XTR:	595081(cybb)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	393386(cybb)

SRX:	107737212 107751141

SANH:

107691306 107695080

SGH:	107569247 107576937

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137021499(cybb)

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:	445888(gp91phox)

TFS:

130522039

TNG:	GSTEN00019431G001

LCO:

TBEN:

CGOB:

PGEO:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

100270807(cybb) 106575674

STRU:

115179597 115196370

OTW:	112253649 112266313

OMY:	100329199(gp91phox) 118936247

OGO:	124021056 124021674

ONE:

115119078

OKI:	109875970 116354027

OKE:

118376411

SALP:

112077474

SNH:	120033766 120042644

CCLU:

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

BFO:

BBEL:

CIN:	100169685(nox2)

SCLV:

120332919 120333101 120345115

SPU:	115928144 594258 757329

LPIC:

129258921 129258928

APLC:

110974417

ARUN:

117296474

AJC:	117105238 117105256

SKO:	100377887 102809132

NVL:

108567087

DPX:	DAPPUDRAFT_263961

PVM:

113829916

HRO:	HELRODRAFT_66368

LGI:	LOTGIDRAFT_180688

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106150924 106156566

LLON:

135487973

NVE:	5509919 5510197

EPA:	110233982 110235063 110248433 110249082

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114538306 114538330

XEN:	124440965 124442591

HMG:	100202604 101236489

HSY:

130645757

RES:

135685042

TAD:	TRIADDRAFT_25818

AQU:

100639820

MNT:	112093711 21394110 21410725

NCR:	NCU10775(nox-2)

NTE:	NEUTE1DRAFT148131(NEUTE1DRAFT_148131)

SMP:	10801784(SMAC4_08741)

PAN:	PODANSg1798

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2117168

MTM:	MYCTH_2066622

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_1472

SSCK:

SPSK_07252

FGR:	FGSG_10807

FPU:	FPSE_08853

FPOA:

FPOAC1_009529

FVN:	FVRRES_10170

FVR:	FVEG_11478

NHE:	NECHADRAFT_93345

FMU:	J7337_009877 J7337_012453

TRE:	TRIREDRAFT_81646

TRR:	M419DRAFT_89254

TATV:

25781717(TrAtP1_008691)

TASP:

36617847(TrAFT101_002743)

MAW:	19245799(J3458_021699)

MAJ:

MAA_04914

MBRN:

26242189(noxA)

PCHM:

VFPPC_03673 VFPPC_07750

CMT:

CCM_01357

AMUS:

LMH87_003961

PLJ:	28884111(PLICBS_005384)

PTKZ:

JDV02_003973

VAL:	VDBG_03457

VDA:	VDAG_09930

CFJ:	CFIO01_08793

CLUP:

CLUP02_12949

CHIG:

CH63R_12188

SAPO:

SAPIO_CDS3817

ELA:	UCREL1_9117

PFY:	PFICI_14637

SSL:	SS1G_11172

BFU:	BCIN_02g04930(BcnoxB)

MBE:

MBM_02981

PSCO:

LY89DRAFT_649551

GLZ:	GLAREA_05336

TMF:	EYB26_009015

TRG:	TRUGW13939_11236

CIM:	CIMG_00491

CPW:	CPC735_057350

URE:	UREG_00528

ABE:

ARB_07242

TVE:

TRV_03949

PBL:	PAAG_05966

PBN:	PADG_06026

AJE:	HCAG_01252

BGH:	BDBG_06745

PNO:	SNOG_12260

PTE:

PTT_13443

PTRR:

6344540(PtrM4_047490)

BZE:	COCCADRAFT_35195

BSC:	COCSADRAFT_109835

BOR:	COCMIDRAFT_107502

AALT:

CC77DRAFT_927857

ARAB:

EKO05_0009771

NPA:	UCRNP2_5073

TML:	GSTUM_00003774001

KMG:	30162058(I203_107493)

TMS:	TREMEDRAFT_32037

TVS:	TRAVEDRAFT_154726

DSQ:	DICSQDRAFT_169781

PCO:	PHACADRAFT_253883

SHS:	STEHIDRAFT_156361 STEHIDRAFT_94006

HIR:	HETIRDRAFT_147877

PSQ:	PUNSTDRAFT_58473

ADL:	AURDEDRAFT_117067

FME:	FOMMEDRAFT_111964

GTR:	GLOTRDRAFT_65323

LBC:	LACBIDRAFT_173015(LbNoxB)

CCI:	CC1G_09830

ABP:	AGABI1DRAFT60718(AGABI1DRAFT_60718)

ABV:	AGABI2DRAFT194938(AGABI2DRAFT_194938)

PCUB:

JR316_0013107

MPR:	MPER_01688

MRR:	Moror_4662 Moror_9356

E1B28_002890 E1B28_006306

SCM:	SCHCO_01038608(SCHCODRAFT_01038608)

CPUT:

CONPUDRAFT_83020

SLA:	SERLADRAFT_386004

WSE:	WALSEDRAFT_31540

WIC:	J056_002411

PGR:	PGTG_04320

PTRC:

PtA15_5A381

PSTR:

Pst134EA_009315

MLR:	MELLADRAFT_43541 MELLADRAFT_70910

RIE:	OCT59_009191 OCT59_022855

MBR:	MONBRDRAFT_33523

SRE:	PTSG_07396

DDI:	DDB_G0289653(noxA)

DPP:	DICPUDRAFT_32111

DFA:	DFA_11184(noxA)

ACAN:

ACA1_370180

TET:	TTHERM_00510191

PIF:	PITG_04250 PITG_15645

PSOJ:

PHYSODRAFT_526416

NGR:	NAEGRDRAFT_80514

» show all

Reference

PMID:2425263

Authors

Royer-Pokora B, Kunkel LM, Monaco AP, Goff SC, Newburger PE, Baehner RL, Cole FS, Curnutte JT, Orkin SH

Title

Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location.

Journal

Nature 322:32-8 (1986)
DOI:10.1038/322032a0

Sequence

[hsa:1536]

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (1)   
   TC (1)   
Pathway (30)   
   KEGG PATHWAY (30)   
Disease (3)   
   KEGG DISEASE (3)   
Gene (2890)   
   KEGG GENES (600)   
   KEGG MGENES (296)   
   RefGene (1988)   
   OC (6)   
Literature (1)   
   PubMed (1)   
All databases (2928)   

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