KEGG   ORTHOLOGY: K21610Help
Entry
K21610                      KO                                     

Name
cfbC
Definition
Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC [EC:6.3.3.7]
Pathway
ko00860  Porphyrin and chlorophyll metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin and chlorophyll metabolism
    K21610  cfbC; Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.7  Ni-sirohydrochlorin a,c-diamide reductive cyclase
     K21610  cfbC; Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC
BRITE hierarchy
Other DBs
RN: R11628
COG: COG1348
Genes
MTH: MTH_643
MMG: MTBMA_c10230(nifH2)
METC: MTCT_0570
MWO: MWSIV6_1015(nifH2)
METE: tca_00613(nifH1_1)
METZ: METMT2_0422
MST: Msp_1120(nifH)
METB: AW729_10175
MSI: Msm_1707
MRU: mru_1466
MEB: Abm4_0733
MMIL: sm9_1376
MEYE: TL18_04160
MOL: YLM1_0966
METH: MBMB1_0311(nifH2)
MFC: BRM9_1962
MFI: DSM1535_0151(nifH2-1)
MCUB: MCBB_0533(nifH2)
METT: CIT01_00825(nifH)
MFV: Mfer_0380
MAC: MA_3627(nifH)
MBAR: MSBR2_1807
MBAK: MSBR3_2862
MMA: MM_0514(nifH2)
MMAC: MSMAC_0771
METM: MSMTP_0886
MTHE: MSTHC_0831
MTHR: MSTHT_2451
MHOR: MSHOH_0895
MFZ: AOB57_003165(cfbC)
MBU: Mbur_1038
MMET: MCMEM_1520
MMH: Mmah_1413
MPY: Mpsy_0958
MTP: Mthe_1178
MCJ: MCON_0503(nifH)
MHI: Mhar_0047
MPD: MCP_0364(nifH-1)
MEZ: Mtc_0064(nifH-1)
RCI: RCIX2002(nifH-2)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3627]

KEGG   ORTHOLOGY: K21611Help
Entry
K21611                      KO                                     

Name
cfbD
Definition
Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD [EC:6.3.3.7]
Pathway
ko00860  Porphyrin and chlorophyll metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin and chlorophyll metabolism
    K21611  cfbD; Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.7  Ni-sirohydrochlorin a,c-diamide reductive cyclase
     K21611  cfbD; Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD
BRITE hierarchy
Other DBs
RN: R11628
COG: COG2710
Genes
MJA: MJ_1423
MFE: Mefer_1398
MVU: Metvu_0736
MFS: MFS40622_0630
MIF: Metin_0570
MJH: JH146_0545
MIG: Metig_1723
MMP: MMP0428
MMQ: MmarC5_1209
MMX: MmarC6_0483
MMD: GYY_02215
MAE: Maeo_1313
MVO: Mvol_1630
MTH: MTH_1522
METC: MTCT_1386
METE: tca_01470(nifD_1)
MST: Msp_1461
MSI: Msm_1160
MRU: mru_0181
MEB: Abm4_0121
MMIL: sm9_0152
MEYE: TL18_10060
MOL: YLM1_1498
METH: MBMB1_0045
MFC: BRM9_0099
MCUB: MCBB_0063
MFV: Mfer_0362
MKA: MK1385(nifD)
MEAR: Mpt1_c08020(bchB2)
MARC: AR505_0362
MAC: MA_3628
MBAR: MSBR2_1806
MBAK: MSBR3_2861
MMA: MM_0515
MMAC: MSMAC_0770
METM: MSMTP_0887
MTHE: MSTHC_0832
MTHR: MSTHT_2450
MHOR: MSHOH_0894
MBU: Mbur_1037
MMET: MCMEM_1519
MMH: Mmah_1412
MPY: Mpsy_0959
MTP: Mthe_0106
MCJ: MCON_1930
MHI: Mhar_2391
MHU: Mhun_0670
MLA: Mlab_0520
MPI: Mpet_1002
MBN: Mboo_1419
MPL: Mpal_0679
MPD: MCP_0363
MEZ: Mtc_0063
RCI: RCIX2003
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3628]

KEGG   ENZYME: 6.3.3.7Help
Entry
EC 6.3.3.7                  Enzyme                                 

Name
Ni-sirohydrochlorin a,c-diamide reductive cyclase;
cfbC (gene name);
cfbD (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Cyclo-ligases
BRITE hierarchy
Sysname
Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + Ni-sirohydrochlorin a,c-diamide + 3 reduced electron acceptor + H2O = ADP + phosphate + 15,173-seco-F430-173-acid + 3 electron acceptor [RN:R11628]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
Ni-sirohydrochlorin a,c-diamide [CPD:C21511];
reduced electron acceptor;
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512];
electron acceptor
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.3.3.7 created 2017
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K21610  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC
K21611  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD
Genes
MJA: MJ_1423
MFE: Mefer_1398
MVU: Metvu_0736
MFS: MFS40622_0630
MIF: Metin_0570
MJH: JH146_0545
MIG: Metig_1723
MMP: MMP0428
MMQ: MmarC5_1209
MMX: MmarC6_0483
MMD: GYY_02215
MAE: Maeo_1313
MVO: Mvol_1630
METE: tca_00613(nifH1_1) tca_01470(nifD_1)
MST: Msp_1120(nifH) Msp_1461
METH: MBMB1_0045 MBMB1_0311(nifH2)
MFI: DSM1535_0151(nifH2-1) DSM1535_1422
MCUB: MCBB_0063 MCBB_0533(nifH2)
MKA: MK1385(nifD)
MEAR: Mpt1_c08020(bchB2)
MARC: AR505_0362
MAC: MA_3627(nifH) MA_3628
MMA: MM_0514(nifH2) MM_0515
MCJ: MCON_0503(nifH) MCON_1930
MHU: Mhun_0670
MLA: Mlab_0520
MPI: Mpet_1002
MBN: Mboo_1419
MPL: Mpal_0679
MPD: MCP_0363 MCP_0364(nifH-1)
MEZ: Mtc_0063 Mtc_0064(nifH-1)
RCI: RCIX2002(nifH-2) RCIX2003
 » show all
Taxonomy
Reference
1  [PMID:3691535]
  Authors
Pfaltz A, Kobelt A, Huster R, Thauer RK
  Title
Biosynthesis of coenzyme F430 in methanogenic bacteria. Identification of 15,17(3)-seco-F430-17(3)-acid as an intermediate.
  Journal
Eur J Biochem 170:459-67 (1987)
Reference
2  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO.
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.3.7
IUBMB Enzyme Nomenclature: 6.3.3.7
ExPASy - ENZYME nomenclature database: 6.3.3.7
BRENDA, the Enzyme Database: 6.3.3.7

KEGG   REACTION: R11628Help
Entry
R11628                      Reaction                               

Name
Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming)
Definition
ATP + Nickel-sirohydrochlorin a,c-diamide + 3 Reduced acceptor + H2O <=> ADP + Orthophosphate + 15,17(3)-Seco-F430-17(3)-acid + 3 Acceptor
Equation
Comment
nickel-sirohydrochlorin a,c-diamide reductase
Enzyme
Pathway
rn00860  Porphyrin and chlorophyll metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Orthology
K21610  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC [EC:6.3.3.7]
K21611  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD [EC:6.3.3.7]
Other DBs
RHEA: 52903

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