KEGG   ORTHOLOGY: K21612
Entry
K21612                      KO                                     

Name
cfbE
Definition
coenzyme F430 synthetase [EC:6.4.1.9]
Pathway
ko00860  Porphyrin and chlorophyll metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin and chlorophyll metabolism
    K21612  cfbE; coenzyme F430 synthetase
Enzymes [BR:ko01000]
 6. Ligases
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.9  coenzyme F430 synthetase
     K21612  cfbE; coenzyme F430 synthetase
Other DBs
RN: R11629
COG: COG0770
Genes
MJA: MJ_0258
MFE: Mefer_0369
MVU: Metvu_0835
MFS: MFS40622_0485
MIF: Metin_0369
MJH: JH146_0166
MIG: Metig_0368
MMP: MMP0173
MMQ: MmarC5_1502
MMX: MmarC6_0778
MMD: GYY_00885
MMAD: MMJJ_09110
MAE: Maeo_1414
MVO: Mvol_1454
MTH: MTH_873
MMG: MTBMA_c12680(murF)
METC: MTCT_0791
METE: tca_00838(murF)
METK: FVF72_07190(cfbE)
MTHM: FZP57_05930(cfbE)
MST: Msp_1331
MRU: mru_1745
MSI: Msm_0880
MEB: Abm4_0460
MMIL: sm9_1831
MEYE: TL18_08530
MOL: YLM1_1199
METH: MBMB1_0355
MFC: BRM9_1909
MCUB: MCBB_0331
MFV: Mfer_1205
MKA: MK1590(murF)
MARC: AR505_0361
MBAR: MSBR2_1805
MBAK: MSBR3_2860
MAC: MA_3630(murD)
MMA: MM_0516
MMAC: MSMAC_0769
METM: MSMTP_0888
MTHR: MSTHT_2449
MTHE: MSTHC_0833
MHOR: MSHOH_0893
MFZ: AOB57_003180(cfbE)
MBU: Mbur_1036
MMET: MCMEM_1518
MMH: Mmah_1411
MPY: Mpsy_0961
MZI: HWN40_03730(cfbE)
MTP: Mthe_0105
MCJ: MCON_1929
MHI: Mhar_2390
MHU: Mhun_0669
MLA: Mlab_0519
MPI: Mpet_1001
MBN: Mboo_1418
MPL: Mpal_0680
MPD: MCP_0362
MEZ: Mtc_0062(murD)
RCI: RCIX2005(murD)
 » show all
Reference
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3630]

KEGG   ENZYME: 6.4.1.9
Entry
EC 6.4.1.9                  Enzyme                                 

Name
coenzyme F430 synthetase;
cfbE (gene name)
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
Sysname
15,173-seco-F430-173-acid cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + 15,173-seco-F430-173-acid = ADP + phosphate + coenzyme F430 [RN:R11629]
Reaction(KEGG)
R11629
Substrate
ATP [CPD:C00002];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
coenzyme F430 [CPD:C05777]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, catalyses the last step in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.4.1.9 created 2017
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K21612  coenzyme F430 synthetase
Genes
MJA: MJ_0258
MFE: Mefer_0369
MVU: Metvu_0835
MFS: MFS40622_0485
MIF: Metin_0369
MJH: JH146_0166
MIG: Metig_0368
MMP: MMP0173
MMQ: MmarC5_1502
MMX: MmarC6_0778
MMD: GYY_00885
MMAD: MMJJ_09110
MAE: Maeo_1414
MVO: Mvol_1454
MTH: MTH_873
MMG: MTBMA_c12680(murF)
METC: MTCT_0791
METE: tca_00838(murF)
METK: FVF72_07190(cfbE)
MTHM: FZP57_05930(cfbE)
MST: Msp_1331
MRU: mru_1745
MSI: Msm_0880
MEB: Abm4_0460
MMIL: sm9_1831
MEYE: TL18_08530
MOL: YLM1_1199
METH: MBMB1_0355
MFC: BRM9_1909
MCUB: MCBB_0331
MFV: Mfer_1205
MKA: MK1590(murF)
MARC: AR505_0361
MBAR: MSBR2_1805
MBAK: MSBR3_2860
MAC: MA_3630(murD)
MMA: MM_0516
MMAC: MSMAC_0769
METM: MSMTP_0888
MTHR: MSTHT_2449
MTHE: MSTHC_0833
MHOR: MSHOH_0893
MFZ: AOB57_003180(cfbE)
MBU: Mbur_1036
MMET: MCMEM_1518
MMH: Mmah_1411
MPY: Mpsy_0961
MZI: HWN40_03730(cfbE)
MTP: Mthe_0105
MCJ: MCON_1929
MHI: Mhar_2390
MHU: Mhun_0669
MLA: Mlab_0519
MPI: Mpet_1001
MBN: Mboo_1418
MPL: Mpal_0680
MPD: MCP_0362
MEZ: Mtc_0062(murD)
RCI: RCIX2005(murD)
 » show all
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO.
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3630]
Other DBs
ExplorEnz - The Enzyme Database: 6.4.1.9
IUBMB Enzyme Nomenclature: 6.4.1.9
ExPASy - ENZYME nomenclature database: 6.4.1.9
BRENDA, the Enzyme Database: 6.4.1.9

KEGG   REACTION: R11629
Entry
R11629                      Reaction                               

Name
15,17(3)-seco-F430-17(3)-acid cyclo-ligase (ADP-forming)
Definition
15,17(3)-Seco-F430-17(3)-acid + ATP <=> Coenzyme F430 + ADP + Orthophosphate
Equation
Enzyme
Pathway
rn00860  Porphyrin and chlorophyll metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Orthology
K21612  coenzyme F430 synthetase [EC:6.4.1.9]
Other DBs
RHEA: 52907

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