KEGG   ORTHOLOGY: K21618
Entry
K21618                      KO                                     

Name
DLD3
Definition
(R)-2-hydroxyglutarate---pyruvate transhydrogenase [EC:1.1.99.40]
Pathway
ko00620  Pyruvate metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K21618  DLD3; (R)-2-hydroxyglutarate---pyruvate transhydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.99  With unknown physiological acceptors
    1.1.99.40  (R)-2-hydroxyglutarate---pyruvate transhydrogenase
     K21618  DLD3; (R)-2-hydroxyglutarate---pyruvate transhydrogenase
Other DBs
RN: R11593
COG: COG0277
Genes
QSU: 111983797 112000937
SCE: YDL178W(DLD2) YEL071W(DLD3)
AGO: AGOS_ACL021C
ERC: Ecym_8034
KLA: KLLA0_F05753g
KMX: KLMA_60482(DLD2)
LTH: KLTH0A05280g
ZRO: ZYRO0C09218g
CGR: CAGL0J06314g
NCS: NCAS_0E03520(NCAS0E03520) NCAS_0H00160(NCAS0H00160)
NDI: NDAI_0A03060(NDAI0A03060) NDAI_0H04030(NDAI0H04030)
TPF: TPHA_0A03280(TPHA0A03280)
TBL: TBLA_0F01970(TBLA0F01970)
TDL: TDEL_0A08020(TDEL0A08020) TDEL_0E05730(TDEL0E05730) TDEL_0H01580(TDEL0H01580)
KAF: KAFR_0L01170(KAFR0L01170)
PIC: PICST_89565(DLD2)
CAL: CAALFM_C303040WA(AIP2)
SLB: AWJ20_5329(DLD2)
NCR: NCU06441
NTE: NEUTE1DRAFT146088(NEUTE1DRAFT_146088)
MGR: MGG_12830
SSCK: SPSK_03231
MAW: MAC_00625
MAJ: MAA_05955
CMT: CCM_01480
MBE: MBM_06930
ANI: AN8033.2
ANG: ANI_1_1492024(An02g10670)
ABE: ARB_00809
TVE: TRV_00678
PTE: PTT_18111
TASA: A1Q1_08226
MRR: Moror_99
ABP: AGABI1DRAFT110375(AGABI1DRAFT_110375)
ABV: AGABI2DRAFT60921(AGABI2DRAFT_60921)
MGL: MGL_2442
MRT: MRET_3321
TEA: KUI_1540
TEG: KUK_0841
TAS: TASI_1515
TAT: KUM_0204
AMIM: MIM_c39590
 » show all
Reference
  Authors
Becker-Kettern J, Paczia N, Conrotte JF, Kay DP, Guignard C, Jung PP, Linster CL
  Title
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
  Journal
J Biol Chem 291:6036-58 (2016)
DOI:10.1074/jbc.M115.704494
  Sequence

KEGG   ENZYME: 1.1.99.40
Entry
EC 1.1.99.40                Enzyme                                 

Name
(R)-2-hydroxyglutarate---pyruvate transhydrogenase;
DLD3 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
(R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming]
Reaction(IUBMB)
(R)-2-hydroxyglutarate + pyruvate = 2-oxoglutarate + (R)-lactate [RN:R11593]
Reaction(KEGG)
R11593
Substrate
(R)-2-hydroxyglutarate [CPD:C01087];
pyruvate [CPD:C00022]
Product
2-oxoglutarate [CPD:C00026];
(R)-lactate [CPD:C00256]
Comment
The enzyme, characterized in the yeast Saccharomyces cerevisiae, also functions as EC 1.1.2.4, D-lactate dehydrogenase (cytochrome), and is active with oxaloacetate as electron acceptor forming (R)-malate.
History
EC 1.1.99.40 created 2017
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Orthology
K21618  (R)-2-hydroxyglutarate---pyruvate transhydrogenase
Genes
QSU: 111983797 112000937
SCE: YDL178W(DLD2) YEL071W(DLD3)
AGO: AGOS_ACL021C
ERC: Ecym_8034
KLA: KLLA0_F05753g
KMX: KLMA_60482(DLD2)
LTH: KLTH0A05280g
ZRO: ZYRO0C09218g
CGR: CAGL0J06314g
NCS: NCAS_0E03520(NCAS0E03520) NCAS_0H00160(NCAS0H00160)
NDI: NDAI_0A03060(NDAI0A03060) NDAI_0H04030(NDAI0H04030)
TPF: TPHA_0A03280(TPHA0A03280)
TBL: TBLA_0F01970(TBLA0F01970)
TDL: TDEL_0A08020(TDEL0A08020) TDEL_0E05730(TDEL0E05730) TDEL_0H01580(TDEL0H01580)
KAF: KAFR_0L01170(KAFR0L01170)
PIC: PICST_89565(DLD2)
CAL: CAALFM_C303040WA(AIP2)
SLB: AWJ20_5329(DLD2)
NCR: NCU06441
NTE: NEUTE1DRAFT146088(NEUTE1DRAFT_146088)
MGR: MGG_12830
SSCK: SPSK_03231
MAW: MAC_00625
MAJ: MAA_05955
CMT: CCM_01480
MBE: MBM_06930
ANI: AN8033.2
ANG: ANI_1_1492024(An02g10670)
ABE: ARB_00809
TVE: TRV_00678
PTE: PTT_18111
TASA: A1Q1_08226
MRR: Moror_99
ABP: AGABI1DRAFT110375(AGABI1DRAFT_110375)
ABV: AGABI2DRAFT60921(AGABI2DRAFT_60921)
MGL: MGL_2442
MRT: MRET_3321
TEA: KUI_1540
TEG: KUK_0841
TAS: TASI_1515
TAT: KUM_0204
AMIM: MIM_c39590
 » show all
Reference
1  [PMID:26774271]
  Authors
Becker-Kettern J, Paczia N, Conrotte JF, Kay DP, Guignard C, Jung PP, Linster CL
  Title
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
  Journal
J Biol Chem 291:6036-58 (2016)
DOI:10.1074/jbc.M115.704494
  Sequence
[sce:YEL071W]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.40
IUBMB Enzyme Nomenclature: 1.1.99.40
ExPASy - ENZYME nomenclature database: 1.1.99.40
BRENDA, the Enzyme Database: 1.1.99.40

KEGG   REACTION: R11593
Entry
R11593                      Reaction                               

Name
(R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming]
Definition
Pyruvate + (R)-2-Hydroxyglutarate <=> (R)-Lactate + 2-Oxoglutarate
Equation
Reaction class
RC00044  C00022_C00256
Enzyme
Pathway
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
Orthology
K21618  (R)-2-hydroxyglutarate---pyruvate transhydrogenase [EC:1.1.99.40]

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