KEGG   ORTHOLOGY: K21639
Entry
K21639                      KO                                     

Name
E1.4.3.25
Definition
L-arginine oxidase [EC:1.4.3.25]
Pathway
ko00330  Arginine and proline metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K21639  E1.4.3.25; L-arginine oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.3  With oxygen as acceptor
    1.4.3.25  L-arginine oxidase
     K21639  E1.4.3.25; L-arginine oxidase
Other DBs
RN: R11604
Genes
SYC: syc0596_c
SYF: Synpcc7942_0946
SYU: M744_11970
Reference
  Authors
Gau AE, Heindl A, Nodop A, Kahmann U, Pistorius EK
  Title
L-amino acid oxidases with specificity for basic L-amino acids in cyanobacteria.
  Journal
Z Naturforsch C 62:273-84 (2007)
DOI:10.1515/znc-2007-3-419
  Sequence
[syc:syc0596_c]
Reference
PMID:8547316
  Authors
Bockholt R, Masepohl B, Kruft V, Wittmann-Liebold B, Pistorius EK
  Title
Partial amino acid sequence of an L-amino acid oxidase from the cyanobacterium Synechococcus PCC6301, cloning and DNA sequence analysis of the aoxA gene.
  Journal
Biochim Biophys Acta 1264:289-93 (1995)
DOI:10.1016/0167-4781(95)00154-9
  Sequence
[syc:syc0596_c]

KEGG   ENZYME: 1.4.3.25
Entry
EC 1.4.3.25                 Enzyme                                 

Name
L-arginine oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
Sysname
L-arginine:oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
L-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + NH3 + H2O2 [RN:R11604]
Reaction(KEGG)
R11604
Substrate
L-arginine [CPD:C00062];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
5-guanidino-2-oxopentanoate [CPD:C03771];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
Contains FAD. The enzyme from cyanobacteria can also act on other basic amino acids with lower activity. The enzyme from the bacterium Pseudomonas sp. TPU 7192 is highly specific.
History
EC 1.4.3.25 created 2017
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K21639  L-arginine oxidase
Genes
SYC: syc0596_c
SYF: Synpcc7942_0946
SYU: M744_11970
Reference
1  [PMID:5570437]
  Authors
Miller DL, Rodwell VW
  Title
Metabolism of basic amino acids in Pseudomonas putida. Intermediates in L-arginine catabolism.
  Journal
J Biol Chem 246:5053-8 (1971)
Reference
2  [PMID:6766743]
  Authors
Pistorius EK, Voss H
  Title
Some properties of a basic L-amino-acid oxidase from Anacystis nidulans.
  Journal
Biochim Biophys Acta 611:227-40 (1980)
DOI:10.1016/0005-2744(80)90059-5
Reference
3  [PMID:17542496]
  Authors
Gau AE, Heindl A, Nodop A, Kahmann U, Pistorius EK
  Title
L-amino acid oxidases with specificity for basic L-amino acids in cyanobacteria.
  Journal
Z Naturforsch C 62:273-84 (2007)
DOI:10.1515/znc-2007-3-419
  Sequence
[syc:syc0596_c]
Reference
4  [PMID:26672462]
  Authors
Matsui D, Terai A, Asano Y
  Title
L-Arginine oxidase from Pseudomonas sp. TPU 7192: Characterization, gene cloning, heterologous expression, and application to L-arginine determination.
  Journal
Enzyme Microb Technol 82:151-7 (2016)
DOI:10.1016/j.enzmictec.2015.10.002
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.25
IUBMB Enzyme Nomenclature: 1.4.3.25
ExPASy - ENZYME nomenclature database: 1.4.3.25
BRENDA, the Enzyme Database: 1.4.3.25

KEGG   REACTION: R11604
Entry
R11604                      Reaction                               

Name
L-arginine:oxygen oxidoreductase (deaminating)
Definition
L-Arginine + H2O + Oxygen <=> 5-Guanidino-2-oxopentanoate + Ammonia + Hydrogen peroxide
Equation
Reaction class
RC00006  C00062_C03771
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K21639  L-arginine oxidase [EC:1.4.3.25]
Other DBs
RHEA: 51407

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