KEGG   ORTHOLOGY: K21672
Entry
K21672                      KO                                     

Name
ord
Definition
2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
Pathway
map00310  Lysine degradation
map00330  Arginine and proline metabolism
map00470  D-Amino acid metabolism
map00472  D-Arginine and D-ornithine metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
   00330 Arginine and proline metabolism
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
  09106 Metabolism of other amino acids
   00470 D-Amino acid metabolism
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.12  2,4-diaminopentanoate dehydrogenase
     K21672  ord; 2,4-diaminopentanoate dehydrogenase
    1.4.1.26  2,4-diaminopentanoate dehydrogenase (NAD+)
     K21672  ord; 2,4-diaminopentanoate dehydrogenase
Other DBs
RN: R02825 R04200 R04201 R04687 R04688
GO: 0047530
Genes
CEH: CEW89_15600
EAV: EH197_05050
VCP: H9L18_06400
VHY: G7082_14535
CSQ: CSCA_0127
CACE: CACET_c17480(dapB2)
CEU: A7L45_16560
CFM: BJL90_14515
CARG: RSJ17_08675
CDRK: B9W14_17905
AMT: Amet_2367
AOE: Clos_1699
CDF: CD630_04420(ord)
PDC: CDIF630_00570(ord)
PDF: CD630DERM_04420(ord)
CST: CLOST_1294(ord)
TTE: TTE1234
THX: Thet_1426
TOC: Toce_1489
KME: H0A61_00511(ord)
PFT: JBW_01651
MPHU: MPHO_01310
PAC: PPA2276
PAW: PAZ_c23740(dapB2)
PACC: PAC1_11610
PACH: PAGK_2185
CACN: RN83_00010
SBR: SY1_03600
TME: Tmel_0905
TAF: THA_1160
THER: Y592_05345
FNO: Fnod_1646
OCY: OSSY52_03900(ord)
PMO: Pmob_1166
MARN: LN42_08170
DTN: DTL3_0759
KOL: Kole_0356
ASAC: ATHSA_0997
AG: CAQ42978(ord)
 » show all
Reference
PMID:4684685
  Authors
Somack R, Costilow RN
  Title
2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein.
  Journal
J Biol Chem 248:385-8 (1973)
  Sequence
Reference
  Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M
  Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
  Journal
J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08
  Sequence

KEGG   ENZYME: 1.4.1.12
Entry
EC 1.4.1.12                 Enzyme                                 

Name
2,4-diaminopentanoate dehydrogenase;
2,4-diaminopentanoic acid C4 dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)
Reaction(IUBMB)
(2R,4S)-2,4-diaminopentanoate + H2O + NAD(P)+ = (2R)-2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+ [RN:R04200 R04201]
Reaction(KEGG)
Substrate
(2R,4S)-2,4-diaminopentanoate [CPD:C03943];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
(2R)-2-amino-4-oxopentanoate [CPD:C03341];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].
History
EC 1.4.1.12 created 1976, modified 2017
Pathway
ec00310  Lysine degradation
ec00330  Arginine and proline metabolism
ec00470  D-Amino acid metabolism
ec00472  D-Arginine and D-ornithine metabolism
ec01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase
Genes
CEH: CEW89_15600
EAV: EH197_05050
VCP: H9L18_06400
VHY: G7082_14535
CSQ: CSCA_0127
CACE: CACET_c17480(dapB2)
CEU: A7L45_16560
CFM: BJL90_14515
CARG: RSJ17_08675
CDRK: B9W14_17905
AMT: Amet_2367
AOE: Clos_1699
CDF: CD630_04420(ord)
PDC: CDIF630_00570(ord)
PDF: CD630DERM_04420(ord)
CST: CLOST_1294(ord)
TTE: TTE1234
THX: Thet_1426
TOC: Toce_1489
KME: H0A61_00511(ord)
PFT: JBW_01651
MPHU: MPHO_01310
PAC: PPA2276
PAW: PAZ_c23740(dapB2)
PACC: PAC1_11610
PACH: PAGK_2185
CACN: RN83_00010
SBR: SY1_03600
TME: Tmel_0905
TAF: THA_1160
THER: Y592_05345
FNO: Fnod_1646
OCY: OSSY52_03900(ord)
PMO: Pmob_1166
MARN: LN42_08170
DTN: DTL3_0759
KOL: Kole_0356
ASAC: ATHSA_0997
 » show all
Reference
1  [PMID:4684685]
  Authors
Somack R, Costilow RN
  Title
2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein.
  Journal
J Biol Chem 248:385-8 (1973)
  Sequence
Reference
2
  Authors
Stadtman, T.C.
  Title
Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase).
  Journal
Adv Enzymol Relat Areas Mol Biol 38:441-445 (1973)
Reference
3  [PMID:4394942]
  Authors
Tsuda Y, Friedmann HC.
  Title
Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide.
  Journal
J Biol Chem 245:5914-26 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.12
IUBMB Enzyme Nomenclature: 1.4.1.12
ExPASy - ENZYME nomenclature database: 1.4.1.12
BRENDA, the Enzyme Database: 1.4.1.12
CAS: 39346-26-4

KEGG   REACTION: R04200
Entry
R04200                      Reaction                               

Name
D-threo-2,4-diaminopentanoate:NAD+ oxidoreductase (deaminating)
Definition
(2R,4S)-2,4-Diaminopentanoate + H2O + NAD+ <=> 2-Amino-4-oxopentanoic acid + Ammonia + NADH + H+
Equation
Comment
R04201 (NADP)
Reaction class
RC00001  C00003_C00004
RC00249  C03341_C03943
Enzyme
1.4.1.12        1.4.1.26
Pathway
rn00470  D-Amino acid metabolism
rn00472  D-Arginine and D-ornithine metabolism
rn01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
Other DBs
RHEA: 24199

KEGG   REACTION: R04201
Entry
R04201                      Reaction                               

Name
D-threo-2,4-diaminopentanoate:NADP+ oxidoreductase(deaminating)
Definition
(2R,4S)-2,4-Diaminopentanoate + NADP+ + H2O <=> 2-Amino-4-oxopentanoic acid + NADPH + Ammonia + H+
Equation
Comment
R04200 (NAD)
Reaction class
RC00001  C00005_C00006
RC00249  C03341_C03943
Enzyme
Pathway
rn00470  D-Amino acid metabolism
rn00472  D-Arginine and D-ornithine metabolism
rn01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
Other DBs
RHEA: 24195

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