KEGG   ORTHOLOGY: K21797
Entry
K21797                      KO                                     

Name
SAC1, SACM1L
Definition
phosphatidylinositol 4-phosphatase [EC:3.1.3.-]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K21797  SAC1, SACM1L; phosphatidylinositol 4-phosphatase
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K21797  SAC1, SACM1L; phosphatidylinositol 4-phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.-  
     K21797  SAC1, SACM1L; phosphatidylinositol 4-phosphatase
Other DBs
RN: R11680
GO: 0034596
Genes
HSA: 22908(SACM1L)
PTR: 460317(SACM1L)
PPS: 100978035(SACM1L)
GGO: 101142954(SACM1L)
PON: 100172954(SACM1L)
NLE: 100605378(SACM1L)
MCC: 714107(SACM1L)
MCF: 102131726(SACM1L)
CSAB: 103227520(SACM1L)
RRO: 104671341(SACM1L)
RBB: 108517657(SACM1L)
CJC: 100395275(SACM1L)
SBQ: 101037363(SACM1L)
MMU: 83493(Sacm1l)
MCAL: 110302457(Sacm1l)
MPAH: 110327212(Sacm1l)
RNO: 116482(Sacm1l)
MUN: 110554134(Sacm1l)
CGE: 100763030(Sacm1l)
NGI: 103733158(Sacm1l)
HGL: 101699134(Sacm1l)
OCU: 100347235(SACM1L)
TUP: 102469456(SACM1L)
CFA: 484795(SACM1L)
VVP: 112912570(SACM1L)
AML: 100483314(SACM1L)
UMR: 103675131(SACM1L)
UAH: 113256778(SACM1L)
ORO: 101383378(SACM1L)
ELK: 111143885
FCA: 101082728(SACM1L)
PTG: 102971620(SACM1L)
PPAD: 109247696(SACM1L)
AJU: 106969116(SACM1L)
BTA: 530577(SACM1L)
BOM: 102273502(SACM1L)
BIU: 109576233(SACM1L)
BBUB: 102414890(SACM1L)
CHX: 102181907(SACM1L)
OAS: 101118997(SACM1L)
SSC: 100621788(SACM1L)
CFR: 102510317(SACM1L)
CDK: 105091296(SACM1L)
BACU: 103007715(SACM1L)
LVE: 103075098(SACM1L)
OOR: 101271726(SACM1L)
DLE: 111163199 111174484(SACM1L)
PCAD: 102995295(SACM1L)
ECB: 100065601(SACM1L)
EPZ: 103555064(SACM1L)
EAI: 106838398(SACM1L)
MYB: 102247976(SACM1L)
MYD: 102766325(SACM1L)
MNA: 107524256(SACM1L)
HAI: 109377471(SACM1L)
DRO: 112309527(SACM1L)
PALE: 102889244(SACM1L)
RAY: 107509088(SACM1L)
MJV: 108396137(SACM1L)
LAV: 100661340(SACM1L)
TMU: 101361648
MDO: 100029916(SACM1L)
PCW: 110209105(SACM1L)
OAA: 100082950(SACM1L)
GGA: 420700(SACM1L)
MGP: 100542586(SACM1L)
CJO: 107309377(SACM1L)
NMEL: 110393128(SACM1L)
APLA: 101804260(SACM1L)
ACYG: 106038316(SACM1L)
TGU: 105760745(SACM1L)
LSR: 110483358(SACM1L)
SCAN: 103813004(SACM1L)
GFR: 102035691(SACM1L)
FAB: 101811241(SACM1L)
PHI: 102108621(SACM1L)
PMAJ: 107200643(SACM1L)
CCAE: 111923590(SACM1L)
CCW: 104689276(SACM1L)
ETL: 114061688(SACM1L)
FPG: 101917770(SACM1L)
FCH: 102053887(SACM1L)
CLV: 102087301(SACM1L)
EGZ: 104123484(SACM1L)
NNI: 104012167(SACM1L)
ACUN: 113476952(SACM1L)
PADL: 103923092(SACM1L)
AAM: 106491165(SACM1L)
ASN: 102371290(SACM1L)
AMJ: 102566758(SACM1L)
PSS: 102453450(SACM1L)
CMY: 102943791(SACM1L)
CPIC: 101935477(SACM1L)
ACS: 100558693(sacm1l)
PVT: 110084875(SACM1L)
PBI: 103066001(SACM1L)
PMUR: 107293785(SACM1L)
TSR: 106552714(SACM1L)
PMUA: 114607089(SACM1L)
GJA: 107111436(SACM1L)
XLA: 444578(sacm1l.L)
XTR: 100497354(sacm1l)
NPR: 108797286(SACM1L)
DRE: 558940(sacm1la) 791142(sacm1lb)
EEE: 113574432(sacm1l) 113583416
TRU: 101075197(sacm1l)
NCC: 104963785(sacm1l)
CSEM: 103388725(sacm1l) 103394320
BPEC: 110163467(sacm1l)
ELS: 105012328 105019184(sacm1l)
SFM: 108942513(sacm1l)
LCM: 102366399
CMK: 103183929(sacm1l)
RTP: 109922039 109937197(sacm1l)
CIN: 100182691
SPU: 100892512
APLC: 110974736
SKO: 100373844
DME: Dmel_CG9128(Sac1)
DER: 6545540
DSE: 6610287
DSI: Dsimw501_GD13597(Dsim_GD13597)
DAN: 6507075
DSR: 110187132
DPE: 6601040
DMN: 108152863
DWI: 6643190
DAZ: 108613060
DNV: 108652211
DHE: 111598795
DVI: 6622802
MDE: 101891040
LCQ: 111680113
AAG: 5569471
AME: 411013
BIM: 100741634
BTER: 100648971
OBB: 114872628
SOC: 105201789
MPHA: 105835144
AEC: 105149877
ACEP: 105621546
PBAR: 105432301
VEM: 105560819
HST: 105184634
DQU: 106746261
CFO: 105252604
LHU: 105668461
PGC: 109855235
OBO: 105287632
PCF: 106788134
NVI: 100122262
CSOL: 105360439
MDL: 103573615
TCA: 659931
DPA: 109543524
ATD: 109597292
NVL: 108566562
BMOR: 101739169
BMAN: 114247902
PMAC: 106717385
PRAP: 111000377
HAW: 110379147
PXY: 105386273
API: 100159265
DNX: 107170256
AGS: 114120490
RMD: 113550666
BTAB: 109032983
CLEC: 106672873
ZNE: 110829178
FCD: 110849106
PVM: 113824669
TUT: 107362245
DPTE: 113798289
PTEP: 107440317
CEL: CELE_F30A10.6(sac-1)
CBR: CBG24498
BMY: Bm1_23585
PCAN: 112576877
CRG: 105325477
MYI: 110466766
OBI: 106878932
SHX: MS3_07976
EGL: EGR_03517
NVE: 5508175
EPA: 110238515
ADF: 107358248
AMIL: 114952559
PDAM: 113675614
SPIS: 111321074
DGT: 114516885
HMG: 100212923
AQU: 109586149
ATH: AT3G51460(RHD4) AT3G51830(SAC8) AT5G66020(ATSAC1B)
LJA: Lj2g3v1644340.1(Lj2g3v1644340.1) Lj2g3v1644340.2(Lj2g3v1644340.2)
DOSA: Os02t0554300-01(Os02g0554300) Os03t0290500-01(Os03g0290500) Os11t0309000-01(Os11g0309000)
ATS: 109765607(LOC109765607) 109778721(LOC109778721) 109779366(LOC109779366)
CRE: CHLREDRAFT_190968(TEF21)
SCE: YKL212W(SAC1)
ERC: Ecym_3618
KMX: KLMA_30028(SAC1)
NCS: NCAS_0A12400(NCAS0A12400) NCAS_0G03570(NCAS0G03570)
NDI: NDAI_0A03810(NDAI0A03810) NDAI_0C02580(NDAI0C02580)
TPF: TPHA_0F03640(TPHA0F03640)
TBL: TBLA_0D03590(TBLA0D03590)
TDL: TDEL_0F00280(TDEL0F00280)
KAF: KAFR_0E00190(KAFR0E00190)
CAL: CAALFM_C109990WA(SAC1)
SLB: AWJ20_3673(SAC1)
NCR: NCU00896(dot)
NTE: NEUTE1DRAFT71397(NEUTE1DRAFT_71397)
SMP: SMAC_01583(putative sac1)
MGR: MGG_11279
MAW: MAC_07271
MAJ: MAA_00761
CMT: CCM_04116
BFU: BCIN_01g01700(Bcsac1)
MBE: MBM_04751
ANI: AN3841.2
ANG: ANI_1_504184(An04g02480)
ABE: ARB_00211
TVE: TRV_05204
PTE: PTT_18093
CNE: CNM00890
CNB: CNBM0780
TASA: A1Q1_00988
MRR: Moror_271
ABP: AGABI1DRAFT110130(AGABI1DRAFT_110130)
ABV: AGABI2DRAFT189975(AGABI2DRAFT_189975)
MGL: MGL_1952
MRT: MRET_1485
DFA: DFA_00895 DFA_01492(sac1)
EHI: EHI_141860(48.t00022)
CPV: cgd4_80
SMIN: v1.2.010337.t1(symbB.v1.2.010337.t1)
 » show all
Reference
  Authors
Nemoto Y, Kearns BG, Wenk MR, Chen H, Mori K, Alb JG Jr, De Camilli P, Bankaitis VA
  Title
Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity.
  Journal
J Biol Chem 275:34293-305 (2000)
DOI:10.1074/jbc.M003923200
  Sequence
[rno:116482]
Reference
  Authors
Foti M, Audhya A, Emr SD
  Title
Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology.
  Journal
Mol Biol Cell 12:2396-411 (2001)
DOI:10.1091/mbc.12.8.2396
Reference
  Authors
Thole JM, Vermeer JE, Zhang Y, Gadella TW Jr, Nielsen E
  Title
Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana.
  Journal
Plant Cell 20:381-95 (2008)
DOI:10.1105/tpc.107.054304
  Sequence
[ath:AT3G51460]
Reference
  Authors
Despres B, Bouissonnie F, Wu HJ, Gomord V, Guilleminot J, Grellet F, Berger F, Delseny M, Devic M
  Title
Three SAC1-like genes show overlapping patterns of expression in Arabidopsis but are remarkably silent during embryo development.
  Journal
Plant J 34:293-306 (2003)
DOI:10.1046/j.1365-313X.2003.01720.x
  Sequence

KEGG   ORTHOLOGY: K21798
Entry
K21798                      KO                                     

Name
SAC2, INPP5F
Definition
phosphatidylinositol 4-phosphatase [EC:3.1.3.-]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K21798  SAC2, INPP5F; phosphatidylinositol 4-phosphatase
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K21798  SAC2, INPP5F; phosphatidylinositol 4-phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.-  
     K21798  SAC2, INPP5F; phosphatidylinositol 4-phosphatase
Other DBs
RN: R11680
GO: 0034596
Genes
HSA: 22876(INPP5F)
PTR: 450780(INPP5F)
PPS: 100978317(INPP5F)
GGO: 101149322(INPP5F)
PON: 100171873(INPP5F)
NLE: 100595771(INPP5F)
MCC: 703808(INPP5F)
MCF: 102137188(INPP5F)
CSAB: 103216614(INPP5F)
RRO: 104672238(INPP5F)
RBB: 108529776(INPP5F)
CJC: 100386345(INPP5F)
SBQ: 101035836(INPP5F) 104650517
MMU: 101490(Inpp5f)
MCAL: 110297883(Inpp5f)
MPAH: 110328461(Inpp5f)
RNO: 309008(Inpp5f)
MUN: 110559808(Inpp5f)
CGE: 100753756(Inpp5f) 100758638
NGI: 103729278(Inpp5f)
HGL: 101708953(Inpp5f)
CCAN: 109690479(Inpp5f)
OCU: 100355074(INPP5F)
CFA: 100856192(INPP5F)
VVP: 112916672(INPP5F)
AML: 100481478(INPP5F)
UMR: 103657758(INPP5F)
UAH: 113252001(INPP5F)
ORO: 101383683(INPP5F)
ELK: 111144865
FCA: 101094453(INPP5F)
PTG: 102972572(INPP5F)
PPAD: 109272984(INPP5F)
AJU: 106969377(INPP5F)
BTA: 539889(INPP5F)
BOM: 102274685(INPP5F)
BIU: 109579161
BBUB: 102391707(INPP5F)
CHX: 102168882(INPP5F)
OAS: 101122650(INPP5F)
SSC: 100144587(INPP5F)
CFR: 102503813(INPP5F)
CDK: 105104280(INPP5F)
BACU: 103007936(INPP5F)
LVE: 103069899(INPP5F)
OOR: 101274003(INPP5F)
DLE: 111172248(INPP5F) 111180171
PCAD: 102973331(INPP5F)
ECB: 100065762(INPP5F)
EAI: 106836411(INPP5F)
MYB: 102246278(INPP5F)
MYD: 102759419(INPP5F) 102768289
MNA: 107532101(INPP5F)
HAI: 109382999(INPP5F)
DRO: 112300438(INPP5F)
PALE: 102898365(INPP5F)
RAY: 107513007(INPP5F)
MJV: 108406695(INPP5F)
LAV: 100659674(INPP5F) 104847095
TMU: 101356115
MDO: 100026005(INPP5F)
SHR: 100914762(INPP5F)
PCW: 110209577(INPP5F)
OAA: 100080657(INPP5F)
GGA: 423932(INPP5F)
MGP: 100540285(INPP5F)
CJO: 107316171(INPP5F)
NMEL: 110399961(INPP5F)
APLA: 101790532(INPP5F)
ACYG: 106045215(INPP5F)
TGU: 100232128(INPP5F)
LSR: 110469993(INPP5F)
SCAN: 103813790(INPP5F)
GFR: 102033070(INPP5F)
FAB: 101814095(INPP5F)
PHI: 102103724(INPP5F)
PMAJ: 107206901(INPP5F)
CCAE: 111930969(INPP5F)
CCW: 104694791(INPP5F)
ETL: 114060957(INPP5F)
FPG: 101915986(INPP5F)
FCH: 102058272(INPP5F)
CLV: 102094457(INPP5F)
EGZ: 104128602(INPP5F)
NNI: 104022359(INPP5F)
ACUN: 113481709(INPP5F)
PADL: 103918546(INPP5F)
AAM: 106499034(INPP5F)
ASN: 102387668(INPP5F)
AMJ: 102576612(INPP5F)
PSS: 102463273(INPP5F)
CMY: 102939221(INPP5F)
CPIC: 101932015(INPP5F)
ACS: 100563460(inpp5f)
PVT: 110075331(INPP5F)
PBI: 103050141(INPP5F)
PMUR: 107288596(INPP5F)
TSR: 106545727(INPP5F)
PMUA: 114597428(INPP5F)
GJA: 107106734(INPP5F)
XLA: 108696021(inpp5f.L)
XTR: 100379801(inpp5f)
DRE: 570007(inpp5f)
SGH: 107559313(inpp5f) 107601800
IPU: 108263127(inpp5f)
PHYP: 113541150(inpp5f)
AMEX: 103030155(inpp5f)
EEE: 113585229(inpp5f)
TRU: 101070653(inpp5f)
LCO: 104921886(inpp5f)
NCC: 104964604(inpp5f)
MZE: 101477493(inpp5f)
ONL: 100701895(inpp5f)
OLA: 101155539(inpp5f)
XMA: 102223863(inpp5f)
XCO: 114138529(inpp5f)
PRET: 103477112(inpp5f)
CVG: 107088732(inpp5f)
NFU: 107375381(inpp5f)
KMR: 108240675(inpp5f)
ALIM: 106535114(inpp5f)
AOCE: 111573117(inpp5f)
CSEM: 103387457(inpp5f)
POV: 109634019(inpp5f)
LCF: 108886247(inpp5f)
SDU: 111220598(inpp5f) 111240300
SLAL: 111669507(inpp5f)
HCQ: 109523147(inpp5f)
BPEC: 110162199(inpp5f)
MALB: 109961649(inpp5f)
ELS: 105028642(inpp5f)
SFM: 108932889(inpp5f)
PKI: 111855063(inpp5f)
LCM: 102347000(INPP5F) 102362511
CMK: 103172448 103185456(inpp5f)
RTP: 109912024(inpp5f)
APLC: 110973889
SKO: 102802450
DME: Dmel_CG7956(CG7956)
DER: 6553402
DSE: 6614339
DSI: Dsimw501_GD19432(Dsim_GD19432)
DAN: 6501376
DSR: 110188428
DPE: 6587629
DMN: 108156336
DWI: 6649656
DAZ: 108620796
DNV: 108660101
DHE: 111601550
DVI: 6630731
MDE: 101890568
LCQ: 111675027
AAG: 5579202
AALB: 109431491
AME: 408546
BIM: 100747266
BTER: 100645303
CCAL: 108623843
OBB: 114872092
SOC: 105199786
MPHA: 105831755
AEC: 105152627
ACEP: 105624677
PBAR: 105432444
VEM: 105568075
HST: 105188002
DQU: 106750276
CFO: 105256229
LHU: 105672433
PGC: 109862610
OBO: 105274776
PCF: 106789295
NVI: 100123683
CSOL: 105361524
MDL: 103570190
TCA: 663138
DPA: 109546226
ATD: 109596537
NVL: 108557540
BMOR: 101741410
BMAN: 114241517
PMAC: 106715540
PRAP: 110991826
HAW: 110373558
BTAB: 109033819
CLEC: 106669312
ZNE: 110830214
FCD: 110856668
TUT: 107362874
DPTE: 113795142
PTEP: 107448175
CEL: CELE_W09C5.7(W09C5.7)
CBR: CBG19771
BMY: Bm1_50070
TSP: Tsp_11809
PCAN: 112563724
SHX: MS3_04519
EGL: EGR_00732
ADF: 107355889
AMIL: 114955762
PDAM: 113680418
SPIS: 111330323
DGT: 114538024
AQU: 100634330
CNE: CNM00740
CNB: CNBM0640
TASA: A1Q1_02463
MRR: Moror_824
ABP: AGABI1DRAFT124923(AGABI1DRAFT_124923)
ABV: AGABI2DRAFT183012(AGABI2DRAFT_183012)
 » show all
Reference
  Authors
Nakatsu F, Messa M, Nandez R, Czapla H, Zou Y, Strittmatter SM, De Camilli P
  Title
Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.
  Journal
J Cell Biol 209:85-95 (2015)
DOI:10.1083/jcb.201409064
  Sequence
[mmu:101490]
Reference
  Authors
Hsu F, Hu F, Mao Y
  Title
Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling.
  Journal
J Cell Biol 209:97-110 (2015)
DOI:10.1083/jcb.201408027

KEGG   REACTION: R11680
Entry
R11680                      Reaction                               

Definition
1-Phosphatidyl-1D-myo-inositol 4-phosphate + H2O <=> 1-Phosphatidyl-D-myo-inositol + Orthophosphate
Equation
Comment
phosphatidyl-myo-inositol-4-phosphate 4-phosphohydrolase
Reaction class
RC00078  C01194_C01277
Enzyme
3.1.3.-
Pathway
rn00562  Inositol phosphate metabolism
rn01100  Metabolic pathways
Orthology
K21797  phosphatidylinositol 4-phosphatase [EC:3.1.3.-]
K21798  phosphatidylinositol 4-phosphatase [EC:3.1.3.-]

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